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Fig. 3 | Allergy, Asthma & Clinical Immunology

Fig. 3

From: Allergic rhinitis, allergic contact dermatitis and disease comorbidity belong to separate entities with distinct composition of T-cell subsets, cytokines, immunoglobulins and autoantibodies

Fig. 3

The ratio of IFN-γ + CD4 + /IL-4 + CD4 + was decreased and the proportion of granzyme B + CD8 + T cells was increased in AR patients. A–E Intracellular cytokine staining was carried out following PMA (50 ng/ml) and ionomycin (1 μg/ml) stimulation for 5 h. Scatter plots showed the percentage of IFN-γ + CD4 + , IL-4 + CD4 + , the ratio of IFN-γ + CD4 + /IL-4 + CD4 + , granzyme B + CD8 + and IFN-γ + CD8 + . HC, healthy controls, n = 28; AR, allergic rhinitis, n = 30; ACD, allergic contact dermatitis, n = 12; AR + ACD, allergic rhinitis combined with allergic contact dermatitis, n = 15. *p < 0.05, **p < 0.01, and ***p < 0.001 (one-way ANOVA and Tukey's multiple comparisons test)

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Allergy, Asthma & Clinical Immunology

ISSN: 1710-1492

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