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Table 1 Suggested modified up-dosing protocol in OFCs for the diagnosis of FPIES

From: Modified oral food challenge protocol approach in the diagnosis of Food Protein-Induced Enterocolitis Syndrome

Dose number

Challenge dosing of trigger food protein

Up-dosing time increments

DOSE 1

1% serving amount

4-weeks

DOSE 2

5% serving amount

4-weeks

DOSE 3

10% serving amount

4-weeks

DOSE 4

20% serving amount

4-weeks

DOSE 5

30% serving amount

4-weeks

DOSE 6

40% serving amount

4-weeks

DOSE 7

60% serving amount

4-weeks

DOSE 8

80% serving amount

4-weeks

DOSE 9

100% serving amount

4-weeks