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Table 13 PI post-diagnosis average annual estimated savings with and without IgG

From: Growth in diagnosis and treatment of primary immunodeficiency within the global Jeffrey Modell Centers Network

Condition

Pre Dx average no. of episodes

Post Dx average no. of episodes

Cost per episode

Pre Dx annual cost

Post Dx annual cost

Post Dx average annual savings

Persistent otitis media

4.2

1.6

$607

$2549

$971

$1578

Serious sinus and upper respiratory infections

4.6

2.1

$1125

$5175

$2362

$2813

Viral infections

3.7

1.4

$2038

$7540

$2853

$4687

Acute bronchitis

3.1

0.8

$468

$1450

$374

$1076

Bacterial pneumonias

2.8

0.6

$4748

$13,294

$2848

$10,446

Chronic obstructive pulmonary disease and bronchiectasis

4.3

1.4

$2136

$9184

$2990

$6194

Hospitalization days

19.8

3.1

$2607

$51,618

$8081

$43,537

Physician/ER visits

70.8

11.7

$367

$25,983

$4293

$21,690

Days on antibiotics

166.2

72.8

$5

$831

$364

$467

School/work days missed

33.9

8.9

$200

$6780

$1780

$5000

Total per patient without IgG

   

$124,404

$26,916

$97,488

Total per patient treated with IgG [impact of IgG treatment weighted for 32% of identified patients in database (average annual cost of IgG ($30,000) × 32%)]

   

$124,404

$36,516

$87,888

  1. The estimated costs of the most frequent conditions affecting PI patients pre- and post-diagnosis and the post-diagnosis average annual savings with and without IgG