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Table 3 Characteristics of 217 patients with positive oral food challenge test at baseline

From: Oropharyngeal symptoms without systemic reactions as a risk factor for food allergen intolerance: a longitudinal pediatric study

Background factor

Tolerance group

Intolerance group

p Value

n = 151

n = 66

 

Egg allergy, n

85

36

 

Male, n (%)

53 (62.4)

22 (57.9)

1.000

Age in months, median (IQR)

24 (13–32)

43 (24–64)

 < 0.001

Atopic dermatitis, n (%)

73 (85.9)

32 (88.9)

0.775

Bronchial asthma, n (%)

7 (8.2)

11 (30.6)

 < 0.001

Allergic rhinitis, n (%)

4 (4.7)

9 (25.0)

 < 0.001

History of anaphylaxis, n (%)

22 (25.9)

18 (50.0)

0.012

Allergic symptoms with low dose OFCa

19 (22.4)

12 (33.3)

0.255

OSw/oS

14 (16.5)

32 (88.9)

 < 0.001

IgE titer

 Total (IU/mL), median (IQR)

168.0 (50–363)

474.5 (266.5–1201)

 < 0.001

 Egg white (IUA/mL), median (IQR)

38.7 (19.7–79.9)

99.9 (64.9–208.8)

 < 0.001

 Ovomucoid (IUA/mL), median (IQR)

29.2 (11.6–56.8)

75.8 (43.6–157.8)

 < 0.001

Milk allergy, n

36

19

 

Male, n (%)

24 (66.7)

15 (71.4)

0.533

Age in months, median (IQR)

21 (17–25)

36 (25–50)

 < 0.001

Atopic dermatitis, n (%)

31 (86.1)

18 (94.7)

0.653

Bronchial asthma, n (%)

3 (8.3)

12 (63.2)

 < 0.001

Allergic rhinitis, n (%)

1 (2.8)

9 (47.4)

 < 0.001

History of anaphylaxis, n (%)

14 (38.9)

15 (78.9)

 < 0.001

Allergic symptoms with low dose OFCa

15 (41.7)

16 (84.2)

 < 0.001

OSw/oS

2 (5.6)

5 (26.3)

0.041

IgE titer

 Total (IU/mL), median (IQR)

178.0 (58.5–477.5)

485.0 (252–1097)

 < 0.001

 Milk (IUA/mL), median (IQR)

22.9 (9.2–38.5)

83.3 (46.7–179.5)

 < 0.001

 Wheat allergy, n

30

11

 

Male, n (%)

19 (61.5)

7 (63.6)

1.000

Age in months, median (IQR)

16 (13–27)

20 (18–26)

0.019

Atopic dermatitis, n (%)

26 (86.7)

10 (90.9)

1.000

Bronchial asthma, n (%)

6 (20.0)

9 (81.8)

 < 0.001

Allergic rhinitis, n (%)

2 (6.7)

3 (27.3)

0.110

History of anaphylaxis, n (%)

4 (13.3)

10 (90.9)

 < 0.001

Allergic symptoms with low dose OFCa

12 (40.0)

10 (90.9)

 < 0.001

OSw/oS

0 (0.0)

0 (0.0)

1.000

IgE titer

 Total (IU/mL), median (IQR)

239.0 (127.5–437.8)

596.0 (193.5–1120)

0.115

 Wheat (IUA/mL), median (IQR)

8.4 (2.5–18.9)

76.4 (13.5–195.0)

 < 0.001

 ω5 gliadin (UA/mL), median (IQR)

1.8 (0.8–5.1)

9.7 (4.3–29.5)

 < 0.001

  1. n number of patients, IQR interquartile range, OFC oral food challenge, OSw/oS Oral and pharyngeal symptoms without systemic reactions
  2. aLow dose OFC: step 1 OFC for egg or wheat and step 2 OFC for milk