Skip to main content
Fig. 3 | Allergy, Asthma & Clinical Immunology

Fig. 3

From: The new era of add-on asthma treatments: where do we stand?

Fig. 3

Selection of treatment options for patients with severe asthma based on clinical evaluation and biomarker levels. Biomarkers shown are not mutually exclusive. *Add-on inhaled therapy such as tiotropium may be considered before initiating biologics therapy because of the comparatively low costs associated with its use [46]. †Response is defined as a reduction in exacerbations and improvement in asthma control within threshold levels. ‡Total IgE levels should be 30–700 IU/mL. §Blood eosinophil count thresholds: reslizumab ≥ 400 µL; mepolizumab ≥ 150 cells/µL, and dupilumab and benralizumab ≥ 300 cells/µL. **Patients with high IgE levels who have blood eosinophil counts ≥ 300 cells/µL may be considered for Th2 biologic therapy. ¶According to GINA 2021 recommendations [2], potential predictors of good asthma response include increasing baseline levels of blood eosinophils and FeNO [82]. FeNO fractional exhaled nitric oxide, FDA Food and Drug Administration, GINA Global Initiative for Asthma, ICS inhaled corticosteroids, Ig immunoglobulin, LABA long-acting β2-agonist, LTRA leukotriene receptor antagonist, OCS oral corticosteroid, Th T helper

Back to article page