Table 1 Clinical and laboratory characteristics of the CF carrier and non-carrier groups
From: CFTR heterozygosity in severe asthma with recurrent airway infections: a retrospective review
CF carriers N = 13 | Non-carriers N = 62 | p value | |
|---|---|---|---|
Mean (SD)/% | Mean (SD)/% | ||
Age (years) | 67 (13.2) | 56 (14.7) | < 0.01 |
Male (%) | 38 | 23 | 1.00 |
BMI > 25 kg/m2 (%) | 54.5 | 65.9 | 1.00 |
FEV1 (L) | 1.76 (0.80) | 2.13 (0.84) | 0.17 |
FEV1 (% predicted) | 65.7 (22.7) | 69.0 (24.7) | 0.65 |
Ever smokers (%) | 50.0 | 57.0 | 1.00 |
Atopy (%) | 50.0 | 67.7 | 0.09 |
Chronic rhinosinusitis (%) | 85.7 | 33.8 | 0.52 |
Bronchiectasis (%) | 70.0 | 41.9 | 0.54 |
Asthma (%) | 46.2 | 50.0 | 1.00 |
Hospitalizations/year | 0.54 (1.23) | 0.11 (0.34) | 0.19 |
% With persistent neutrophilia | 58.3 | 44.4 | 0.52 |
% With persistent intense neutrophilia | 58.3 | 35.2 | 0.19 |
Max neutrophil count (cells × 106/g) | 56.5 (61.0) | 40.1 (45.0) | 0.37 |
Max sputum eosinophils (%) | 8.0 (10.3) | 7.9 (15.11) | 0.57 |
Eosinophilic bronchitis (%) | 58.0 | 40.7 | 0.34 |
Lymphopenia (%) | 61.50 | 50.9 | 0.55 |
IVIG (%) | 25 | 22.6 | 1.00 |
Daily OCS (%) | 30.7 | 35.6 | 1.00 |
HTS (%) | 76.9 | 30.0 | 0.004 |
Azithromycin (%) | 23.1 | 11.1 | 0.36 |