Table 2 Clinical characteristics and treatment of CF carriers with recurrent airway infections
From: CFTR heterozygosity in severe asthma with recurrent airway infections: a retrospective review
# | Age (yrs) | Sex (M/F) | BMI (kg/m2) | CFTR mutation | Intron 8 alleles | FEV1 (L) (% pred) | Asthmaa (y/n) | Bronchiectasis (y/n) | Max sputum eos (%) | Sputum culture | Change in inf/yr with HTS |
|---|---|---|---|---|---|---|---|---|---|---|---|
1 | 51 | F | 35.8 | \(\Delta\)F508 | 7 T/9 T | N/Ab | N/A | N | 6.5 | SA/ST | − 1 |
2 | 75 | M | 25.0 | \(\Delta\)F508 | 9 T/9 T | 2.96 (94) | Y | Y | 0 | – | − 4 |
3 | 51 | F | 32.9 | \(\Delta\)F508 | 7 T/9 T | 2.4 (81) | N | N | 34.5 | – | + 2 |
4 | 78 | M | 25.8 | \(\Delta\)F508 | 7 T/9 T | 1.82 (65) | N | N | 5 | HiB/NC/PA | − 4 |
5 | 47 | M | 33.8 | \(\Delta\)F508 | 7 T/9 T | 1.28 (50) | Y | N | 5.8 | HiB/NTM | + 0 |
6 | 69 | F | 26.2 | \(\Delta\)F508 | 5 T/9 T | 0.32 (16) | N | Y | 0.8 | NTM/PA | N/Ac |
7 | 70 | F | 24.9 | \(\Delta\)F508 | 7 T/9 T | 2.28 (88) | Y | Y | 37.8 | HiB/MC/NTM/PA/SP | − 3 |
8 | 75 | F | 26.0 | c.1175 T>A | 7 T/7 T | 1.03 (61) | N | N | 2 | – | − 1 |
9 | 77 | F | 23.2 | R117H | 5 T/7 T | 1.54 (75) | Y | Y | 19 | – | + 0 |
10 | 54 | F | 40.0 | 621 + 1G > T | 7 T/9 T | 1.17 (48) | Y | N | 14.3 | – | N/Ac |
11 | 62 | M | 31.6 | c.2249C>T | 7 T/9 T | 1.60 (47) | N | Y | 1.5 | – | − 3 |
12 | 76 | M | 21.9 | c.1540G>A | 5 T/7 T | 3.15 (90) | Y | Y | 6.3 | – | + 0 |
13 | 90 | F | 23.1 | S549N | 7 T/9 T | 1.52 (73) | N | Y | 0 | – | N/A |