CFTR heterozygosity in severe asthma with recurrent airway infections: a retrospective review

Table 4 Multivariate comparison between CF carrier and non-carrier groups

Parameter	Adjusted odds ratio (95% CI)	p value
Age	1.06 (1.01, 1.13)	0.03^†
Polymicrobial infection	0.47 (0.07, 2.36)	0.39
Chronic rhinosinusitis	1.68 (0.40, 7.24)	0.47
Bronchiectasis	0.99 (0.23, 4.22)	0.99
Number of neutrophilic flares	1.14 (0.87, 1.45)	0.28
Number of pleiotropic flares	0.86 (0.05, 5.56)	0.88
Hospitalizations per year	4.19 (1.34, 24.74)	0.04^†

Polymicrobial infection was defined as at least two different pathogens identified by sputum culture on two different occasions. A neutrophilic flare was diagnosed when an increase in symptoms was accompanied by sputum total cell count > 15 × 10⁶ cells/g and neutrophils > 65% on cell differential. A pleiotropic flare was similarly diagnosed when sputum total cell count > 15 × 10⁶ cells/g, neutrophils > 65%, and eosinophils > 3% on cell differential
^†Indicates a significant difference between CF carriers and non-carriers at p < 0.05

ISSN: 1710-1492