From: Allergological study in patients vaccinated against COVID-19 with suspected allergic reactions
Patient Nº | Age | Sex | Atopy | Vaccine (dose at which the reaction occurred) | Start and type of reaction (approximate information) | Signs and symptoms | Treatment prescribed | IDT with vaccinea | Continuation of the vaccination program |
---|---|---|---|---|---|---|---|---|---|
1 | 40 | F | Yes | Comirnaty® (1st dose) | 5’ (immediate) | Facial paresthesias with peribucal burning and dizziness | Saline solution | 1/100: + 1/10: + Undiluted: + | 2nd dose Comirnaty®: YES (gradual with premedication)b |
2 | 55 | F | Yes | Comirnaty® (1st dose) | 5’ (immediate) | Pruritus on the palate, dyspnea with 80% SatO2, generalized burning sensation, chronic diarrhea (3 months, from 10 days after vaccination) | IV corticoids IV and adrenaline | 1/100: + 1/10: + Undiluted: + | 2nd dose Comirnaty®: NO (refused vaccination) |
3 | 73 | M | Yes | Comirnaty® (1st dose) | 72 h (Delayed) | Nausea and facial angioedema | IV corticoids and H1A | 1/100: − 1/10: + Undiluted: + | 2nd dose Comirnaty®: YES (gradual with premedication)b |
4 | 73 | F | Yes | Comirnaty® (1st dose) | 30–36 h (Delayed) | Acute generalized urticaria | IV corticoids and H1A | 1/100: − 1/10: − Undiluted: − | 2nd dose Comirnaty®: YES |
5 | 76 | F | No | Comirnaty® (1st dose) | 36–48 h (Delayed) | Generalized pruritus with dyspnea, abdominal swelling, ankle edema, possible subsegmental pulmonary thromboembolism, mild erythematous rash on arms and neckline | IV corticoids and H1A | 1/100: − 1/10: − Undiluted: − | 2nd dose Comirnaty®: NO (refused vaccination) |
6 | 68 | M | No | Comirnaty® (1st dose) | 60’ (Immediate) | Wheals on upper limbs | No | 1/100: − 1/10: − Undiluted: - | 2nd dose Comirnaty®: YES |
7 | 29 | F | Yes | Comirnaty® (1st dose) | 5’ (Immediate) | Generalized erythematous rash with a few papules and facial angioedema, more intense at 24 h | IV corticoids and H1A | 1/100: + 1/10: + Undiluted: not done | 2nd dose Comirnaty®: YES (gradual with premedication)b |
8 | 75 | M | Yes | Comirnaty® (1st dose) | 6 h (Delayed) | Red-vinous macules on lower limbs, upper limbs, thorax and back without itching of 3 weeks of evolution | IM and oral corticoids and H1A | 1/100: − 1/10: − Undiluted: − | 2nd dose Comirnaty®: YES |
9 | 58 | F | Yes | Comirnaty® (1st and 2nd dose) | > 24 h (Delayed) | With the 1st dose, local swelling at 24 h and generalized urticaria at 48 h With 2nd dose, maculopapular rash and coldness in lower limbs at 24 h | H1A | 1/100: − 1/10: + Undiluted: + | 2nd dose Comirnaty®: NO (had passed COVID-19 two months before reaction) |
10 | 51 | F | No | Comirnaty® (1st dose) | 5’ and 24 h (Immediate and delayed) | At 5', erythematous rash on neckline At 24 h, angioedema on the arms and hemiface | IV corticoids and H1A | 1/100: + 1/10: + Undiluted: + | 2nd dose Comirnaty®: YES (gradual with premedication)b |
11 | 28 | F | Yes | Comirnaty® (2nd dose) | 10’ (Immediarte) | Pruritus of the tongue and throat, possible edema of the uvula and swelling of the neck | IV and oral corticoids | 1/100: − 1/10: + Undiluted: + | Not necessary (he received the two doses) |
12 | 17 | F | No | Comirnaty® (1st dose) | 48 h (Delayed) | Wheals on the injection arm, fever and facial angioedema | Oral corticoids and H1A | 1/100: − 1/10: + Undiluted: + | 2nd dose Comirnaty®: NO (had passed COVID-19 one month before reaction) |
13 | 54 | F | No | Spikevax® (2nd dose) | 12–24 h (Delayed) | Fever, generalized urticaria and arthromyalgia | H1A | 1/100: − 1/10: + Undiluted: + | Not necessary (he received the two doses) |
14 | 60 | F | No | Vaxzevria® (1st dose) | 30’ (Immediate) | At 30', generalized erythematous and pruritic rash, dizziness and bruises on lower limbs At 17 days, post-vaccinal headache | IV corticoids, H1A and adrenaline | 1/100: + 1/10: + Undiluted: + | 2nd dose Comirnaty®: NO (refused vaccination) |
15 | 61 | M | Yes | Vaxzevria® (1st and 2nd dose) | 40 h (Delayed) | Acute urticaria-angioedema with both doses | IV corticoids and H1A | 1/100: − 1/10: − Undiluted: − | Not necessary (he received the two doses) |
16 | 24 | F | Yes | Vaxzevria® (1st dose) | 10’ and 28 days (Immediate and delayed) | At 10', abdominal pain, stridor and dyspnea At 28 days, dizziness, vomiting, facial paralysis, severe headache, numbness of lower limbs for < 24 h | IV corticoids and adrenaline | 1/100: − 1/10: + Undiluted: + | 2nd dose Vaxzevria®: NO (refused vaccination) |