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Table 2 Primary and secondary endpoints (full analysis set)

From: Intranasal budesonide for rhinitis during a high airborne pollution period: a randomized controlled trial

 

Budesonide

(N = 103)

Placebo

(N = 103)

P

L.S. Mean (S.E.)a

L.S. Mean (S.E.)a

rTNSS

− 2.20 (0.147)

− 1.72 (0.148)

0.0107

SGIC

− 2.35 (0.085)

− 2.20 (0.085)

0.1047

NO

− 0.73 (0.058)

− 0.60 (0.059)

0.0671

Secretion/RN

− 0.72 (0.054)

− 0.61 (0.055)

0.0781

Itching/SN

− 0.75 (0.055)

− 0.51 (0.056)

0.0009

NO + RN

− 1.45 (0.102)

− 1.21 (0.104)

0.0520

NO + SN

− 1.48 (0.102)

− 1.11 (0.103)

0.0057

RN + SN

− 1.47 (0.100)

− 1.12 (0.101)

0.0065

Cough

− 0.28 (0.052)

− 0.22 (0.053)

0.183

Postnasal drip

− 0.55 (0.051)

− 0.45 (0.052)

0.079

  1. rTNSS reflective total nasal symptom score, SGIC subject-assessed Global Impression of Change, NO nasal obstruction, SN sneezing, RN runny nose
  2. aMixed model for repeated measure (MMRM) including terms for treatment, day, center, and baseline rTNSS as covariates, treatment-by-day, day-by-baseline interaction as well. The within-subject covariance is assumed as unstructured
  3. Bold value indicate the P value < 0.0125 with statistical significance