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Fig. 1 | Allergy, Asthma & Clinical Immunology

Fig. 1

From: KIF2A decreases IL-33 production and attenuates allergic asthmatic inflammation

Fig. 1

Decreased KIF2A and increased autophagy in a mouse model of allergic airway inflammation. A The mouse model of allergic airway inflammation. B KIF2A in lung tissues from mice in the control group and the HDM group was measured with Western blotting and the density quantification of KIF2A was expressed as a ratio relative to β-actin (C) Immunohistochemical staining for KIF2A in lung sections from mice in the control group and the HDM group. Scale bar, 100 μm and AOD was measured with imageJ. D Immunofluorescent staining for KIF2A and prosurfactant protein C (AT2 cell marker) in lung sections from mice in the control group and the HDM group. Scale bar, 100 μm. E The level of autophagy (LC3B and ATG5) in lung tissue from mice in the control group and the HDM group was measured with Western blotting and the density quantification of LC3B and ATG5 was expressed as a ratio relative to β-actin. Data are presented as mean ± SEM of independent experiments with similar results (n = 6 ~ 8). *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001

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