Fig. 1

Changes in rheumatoid arthritis-related parameters after the initiation of allergen immunotherapy (AIT). A simplified disease activity score (SDAI). B matrix metaroproteinase-3 (MMP-3). C c-reactive protein (CRP). For all parameters, comparisons were made between baseline and each of the following time points with the Wilcoxon signed rank test: 1 month, 2 months, 3 months, 6 months, 9 months, 12 months, 15 months, 18 months, 21 months, and 24 months. Each gray line corresponds to an individual value; the median and interquartile ranges are indicated by bold black lines. Two patients had worsening disease activity, which is indicated by the arrows