Table 3 Pharmacogenetics of HLA-associated DIHS
Associated drug | Â | HLA allele | Ethnicity |
|---|---|---|---|
Aromatic anticonvulsants | Carbamazepine | A*31:01 | Northern European, Japanese, Korean |
| Â | Phenytoin | B*51:01 | Thai |
| Â | Â | B*15:13 | Malaysian |
| Â | Lamotrigine | A*24:02 | Spanish |
Uric-acid-lowering drug | Allopurinol | B*58:01 | Han Chinese, Korean, Japanese, Thai, European |
Antriretroviral drug | Abacavir | B*57:01 | European, African |
| Â | Nevirapine | C*04 | African, Han Chinese |
| Â | Â | C*08 or C*08-B*14 haplotype | Italian, Japanese |
Antibiotics | Dapsone | B*13:01 | Han Chinese |