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Table 4 Reported cases of ATDs-induced DIHS

From: Drug-induced hypersensitivity syndrome induced by propylthiouracil: case report and literature review

Study

Ozaki (2005)

Ye (2010)

Our study

Age

50 years

34 years

24 years

Sex

Male

Female

Female

ATDs

MMI

PTU

PTU

Time of onset after ATDs

1.5 months

6 weeks

3 weeks

Fever

Yes

Yes

Yes

Rash

Yes

Yes

Yes

Hematologic abnormality

 Leucocytosis

Yes

NR

No

 Atypical lymphocytosis

No

NR

Yes

 Eosinophilia

NR

Yes

Yes

Liver abnormality

Yes

Yes

Yes

Other affected organs

Lung

NR

Kidney

Lymphademopathy

NR

Yes

Yes

HHV-6 detection

Yes

NR

No

Other virus detection

CMV

NR

No

Treatment

Corticosteroid

Corticosteroid

Corticosteroid, IVIG

  1. ATDs antithyroid drugs, DIHS drug-induced hypersensitivity syndrome, HHV-6 human herpes virus-6, IVIG intravenous immunoglobulin, MMI methimazole, NR not reported, PTU propylthiouracil