Table 2 Ig20Gly infusion and dosing parameters
Initiation (n = 23)a | Post-initiation | |||
|---|---|---|---|---|
3 months (n = 17)a | 6 months (n = 93)b | 12 months (n = 107) | ||
Infusion parameters | ||||
Infusion volume/infusion, median (IQR), ml | 30 (30–40) | 33 (24–45) | 40 (25–50) | 40 (30–50) |
Infusion duration, median (IQR), minutes | 35 (15–58) | 33 (15–45) | 45 (29–63) | 60 (30–65) |
Number of infusion sites/infusion, median (IQR) 1 site, n (%) 2 sites, n (%) 3 sites, n (%) > 3 sites, n (%) | 2 (2–3) 2 (10.5) 11 (57.9) 2 (10.5) 4 (21.1) | 2 (2–4) 1 (7.1) 9 (64.3) 0 4 (28.6) | 2 (2–3) 10 (12.7) 42 (53.2) 15 (19.0) 12 (15.2) | 2 (2–3) 10 (11.5) 49 (56.3) 16 (18.4) 12 (13.8) |
Number of infusions/month/patient, median (IQR) | 4 (4–4) | 4 (4–4) | 4 (4–4) | 4 (4–4) |
Maximal infusion rate/site, median (IQR), ml/h | 40.0 (35.0–45.0) | 50.9 (50.9–50.9) | 43.3 (32.7–58.0) | 40.0 (34.0–59.0) |
Infusions, n (%), that were: | ||||
Interrupted Slowed Neither slowed nor interrupted Unknown | 0 0 12 (52.2) 11 (47.8) | 0 0 12 (70.6) 5 (29.4) | 0 1 (1.1) 72 (77.4) 20 (21.5) | 1 (0.9) 1 (0.9) 76 (71.0) 29 (27.1) |
Dosing parameters | ||||
Weekly dose, median (IQR), g | 7.5 (6.0–8.0) | 6.5 (5.6–8.0) | 8.0 (6.0–10.0) | 8.0 (6.0–10.0) |
Weekly dose per kg, median (IQR), g/kg | 0.1 (0.1–0.1) | 0.1 (0.1–0.1) | 0.1 (0.1–0.1) | 0.1 (0.1–0.1) |
Dosing interval, n (%) | ||||
Daily 2–6 times/week Once weekly Every 2 weeks Other | 0 5 (21.7) 16 (69.6) 2 (8.7) 0 | 0 2 (11.8) 13 (76.5) 2 (11.8) 0 | 1 (1.1) 19 (20.4) 65 (69.9) 7 (7.5) 1 (1.1) | 0 19 (17.9) 81 (76.4) 4 (3.8) 2 (1.9) |
IgG trough levels, g/lc | ||||
Median (IQR) Range | 7.8 (7.4–10.7)d 0.8–12.1 | 11.5 (4.7–11.6) 4.7–11.6 | 9.5 (7.9–10.7) 5.0–14.4 | 8.8 (8.0–10.9) 3.6–14.5 |