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Table 2 Clinically recorded results with statistical assessment before and after treatment with topical sodium chloride and TSPP

From: The effect of intra-nasal tetra sodium pyrophosphate on decreasing elevated nasal calcium and improving olfactory function post COVID-19: a randomized controlled trial

 

Sodium chloride

TSPP

Population size clinical assessment results

Pre administration

Post administration

p

Pre administration

Post administration

p

Population size with anosmia, n

32

32

1

32

6

0.024

Population size with hyposmia, n

0

0

1

0

26

0.024

Male population size with anosmia, n

14

14

1

12

4

0.001

Male population size with hyposmia, n

0

0

1

0

8

0.001

Female population size with anosmia, n

18

18

1

20

2

0.0001

Female population size with hyposmia,(n,%)

0

0

1

0

18

0.0001

 

Measured Sniffin' Sticks TDI olfactory scores and measured calcium levels

Pre administration

Post administration

t (2.03)

Pre administration

Post administration

t (2.03)

T score, mean ± SD

2.34 ± 0.48

2.43 ± 0.50

1.79

2.41 ± 0.49

3.55 ± 0.64

7.97

D score, mean ± SD

4.47 ± 0.42

4.45 ± 0.41

1.69

4.48 ± 0.43

6.50 ± 1.13

8.87

I score, mean ± SD

4.29 ± 0.44

4.38 ± 0.45

1.69

4.39 ± 0.44

6.78 ± 1.16

10.84

TDI score, mean ± SD

11.10 ± 0.99

11.26 ± 0.72

2.01

11.28 ± 0.79

16.83 ± 2.13

11.88

Nasal calcium concentration (mM), mean ± SD

37.68 ± 1.80

36.40 ± 1.46

1.69

37.63 ± 2.14

29.18 ± 4.65

10.13

Mean ∆TDI ± SD

0.23 ± 0.36

5.41 ± 2.52

11.25

Mean ∆ calcium concentration ± SD

1.28 ± 1.02

8.44 ± 4.71

8.39

  1. The significant difference indicated by the bold values, values in the parenthesis are the theoretical t values