Table 3 XTT–LTT results for the 10 patients enrolled in the study
Patient | Implicated and culprit drugs | Cells per well | One way ANOVA | Stimulation Index (> 2 positive, < 2 negative) | Cytokines (pg/ml) | ||
|---|---|---|---|---|---|---|---|
IL2 | IL4 | IL5 | |||||
P1 | Vancomycin | 200,000 | Vancomycin 100 µg/ml * | Vancomycin 100 µg/ml (2.57) | − ve | − ve | 0.3 |
P2 † | Piperacillin/Tazobactam (Tazocin) Ceftriaxone (NEG) Ceftotaxime (NEG) Cefazolin (NEG) Ceftazidime (NEG) Amoxyicillin (NEG) Benzylpenicillin (NEG) | 153.000 | Piperacillin/Tazobactam (Tazocin) 100 µg/ml* | Piperacillin/Tazobactam (Tazocin) 100 µg/ml (2.33) | − ve | − ve | 15–50 |
P3 † | Sulphasalazine Sulfapyridine Sulfamethoxazole Sulfamethoxazole + trimethoprim | 200,000 | Sulphasalazine (50 µg/ml***, 25 µg/ml* and 12.5 µg/ml*** Sulfapyridine 12.5 µg/ml*, 6.25 µg/ml** 3.12 µg/ml** Sulfamethoxazole 100 µg/ml**, 50 µg/ml*** Sulfamethoxazole + trimethoprim (NS) | Sulphasalazine 100 µg/ml (2.2) 50 µg/ml (3.3), 25 µg/ml (2.6), 12.5 µg/ml (3.3) Sulfapyridine12.5 µg/ml (2.55), 6.25 µg/ml (2.9), 3.12 µg/ml (2.97) Sulfamethoxazole 100 µg/ml (3.78), 50 µg/ml (2.66), 25 µg/ml (2.13) Sulfamethoxazole + trimethoprim 50 µg/ml (2.46), 25 µg/ml (2.0) | − ve | 0.44 | 2–5 |
P4 † | Allopurinol Oxypurinol | 200,000 | Allopurinol 25 µg/ml* Oxypurinol 3.1 µg/ml* | Allopurinol 100 µg/ml (2.19) 25 µg/ml (2.63), 12.5 µg/ml (2.15) | − ve | − ve | − ve |
P5 † | Sulphasalazine Sulfapyridine (NEG) Sulfamethoxazole (NEG) Sulfamethoxazole + trimethoprim (NEG) | 170,000 | Sulphasalazine (25 µg/ml*) | Sulphasalazine 25 µg/ml (4.97) | − ve | − ve | − ve |
P6 | Apixaban | 200,000 | Apixaban (25 µg/ml**,12.5 µg/ml**, 6.25 µg/ml and 3.1 µg/ml) | Apixaban All SI < 2 | NT | NT | NT |
P7 † | Piperacillin/Tazobactam (Tazocin) | 186,000 | Piperacillin/Tazobactam (Tazocin) (100 µg/ml*** and 6.25 µg/ml*) | Piperacillin/Tazobactam (Tazocin) 100 µg/ml (3.16) 6.25 µg/ml (2.45) | − ve | − ve | 5–10 |
P8 † | Amoxicillin + clavulanic acid Amoxicillin (NEG) | 200,000 | Amoxicillin + clavulanic acid (NS) | Amoxicillin + clavulanic acid 25 µg/ml (2.43) | − ve | 0.3–0.7 | 0.5–2.4 l |
P9 | Lenalidomide Allopurinol (NEG) Oxypurinol (NEG) | 200,000 | Lenalidomide (50 µg/ml* and 6.25 µg/ml*) | Lenalidomide SI < 2 | − ve | NT | NT |
P10 | Benzylpenicillin Flucloxacillin Ceftazolin-AFT | 200,000 | Benzylpenicillin (NS) Flucloxacillin (NS) Ceftazolin-AFT 3.12 µg/ml* | Benzylpenicillin 12.5 µg/ml (3.75), 6.25 µg/ml (3.56) Flucloxacillin 25 µg/ml (4.03), 12,5 µg/ml (3.3), 6.25 µg/ml (3.45), 3.12 µg/ml (3.14) Ceftazolin-AFT 50 µg/ml (3.44), 12.5 µg/ml (2.5), 6.25 µg/ml (3.66), 3.12 µg/ml (4.02) | − ve | NT | NT |