Table 1 Clinical and immunologic data of IEI patients with different types of malignancies
From: Diversity of malignancies in patients with different types of inborn errors of immunity
Parameters | HL (n = 19) | NHL (n = 36) | Leukemia (n = 9) | Solid tumor (n = 15) | p value* |
|---|---|---|---|---|---|
Clinical presentations | Â | ||||
 Sex ratio (M/F) | 9/10 | 20/16 | 6/3 | 10/5 | 0.28 |
 Consanguinity (%) | 8(42.1) | 23(63.9) | 3 (33.3) | 11 (73.3) | 0.78 |
 Death (%) | 8(42.1) | 13(36.1) | 2(22.2) | 3(20.0) | 0.20 |
 Age at the onset of IEI, year, median (IQR) | 5(0.5–7) | 3(1–7) | 3(0.75–48) | 5.2(2.5–12.2) | 0.21 |
 Age at the diagnosis of malignancy, year, median (IQR) | 17.3 (8.5–26.0) | 14.0 (6.5–21.7) | 15.2 (10.5–23) | 18.5 (10.0–27.5) | 0.38 |
 Current age, year median (IQR) | 25 (11–29) | 17 (11–31) | 18.5 (3.7–26.7) | 25 (12–39) | 0.21 |
 Otitis media (%) | 9 (47.4) | 13 (36.1) | 1 (11.1) | 4 (26.7) | 0.82 |
 Sinusitis (%) | 11 (57.9) | 14 (38.9) | 1 (11.1) | 7 (46.7) | 0.25 |
 Pneumonia (%) | 10 (52.6) | 19 (52.8) | 5 (55.6) | 7 (46.7) | 0.09 |
 Bronchiectasis (%) | 2 (10.5) | 8 (22.2) | 2 (22.2) | 6 (40.0) | 0.05* |
 Severe infections (%) | 3 (15.8) | 1 (2.7) | 2 (22.2) | 0 | 0.33 |
 Chronic enteropathy (%) | 3 (15.8) | 4 (11.1) | 0 | 6 (40.0) | 0.003* |
 Failure to thrive (%) | 3 (15.8) | 8 (22.2) | 1 (11.1) | 4 (26.7) | 0.17 |
 Lymphoproliferation (%) | 6 (31.6) | 12 (33.3) | 0 | 4 (26.7) | 0.69 |
 Autoimmunity (%) | 6 (31.6) | 5 (13.9) | 2 (22.2) | 2 (13.3) | 0.62 |
 Allergy and atopic diseases (%) | 3 (15.8) | 8 (22.2) | 2 (22.2) | 2 (13.3) | 0.45 |