Table 1 Summary of Laboratory Investigations in Two Siblings at the Time of Diagnosis
Laboratory parameters | Patient 1 (age: 16Â months) | Patient 2 (age: 12Â months) | Reference value |
|---|---|---|---|
WBC (cells/mm3) | 5700 | 3900 | 6000–17000 |
Lymphocyte (cells/mm3) | 1938 | 663 | 3000–9500 |
Neutrophil (cells/mm3) | 1026 | 2496 | 1500–8500 |
Eosinophil (cells/mm3) | 114 | 195 | 165–465 |
IgG (mg/dL) | 849 | 875†| 246–904 |
IgM (mg/dL) | 256 | 44 | 40–143 |
IgA (mg/dL) | 47 | 174 | 27–66 |
IgE (IU/mL) | 475 | 170 | Up to 68 |
Anti-D IgG (IU/mL) |  < 0.01 | 0.006 |  < 0.1: No response 0.1–1: Poor response ˃1: Normal response |
Anti-T IgG (IU/mL) | 0.05 | 0.39 |  < 0.1: No response 0.1–1: Poor response ˃1: Normal response |
Plt (× 103 cells/mm3) | 1091 | 738 | 150–450 |
CD3 + T cells (% of lymphocytes) | 79% | 30% | 50–90 |
CD4 + T cells (% of lymphocytes) | 12% | 22% | 20–65 |
CD8 + T cells (% of lymphocytes) | 50% | 2% | 5–40 |
CD19 + B cells (% of lymphocytes) | 2% | 27.5% | 3–40 |
CD16 + NK cells (% of lymphocytes) | 15% | 16.7% | 3–15 |
CD56 + NK cells (% of lymphocytes) | 19% | 21% | 3–15 |
NBT | 100% | 100% |  > 95 |
CRP | 112 | 3 |  < 10 |
LTT | |||
 PHA | 4.8 | 4.9 |  ≥ 3 |
 BCG | 1.1 | 1.4 |  ≥ 2.5 |
 Candida | 1.8 | 2.0 |  ≥ 2.5 |