Table 1 Summary of clinical features, laboratory, and imaging details of the two cases

Dose no

2

3 (Booster)

2

3 (Booster)

Symptoms prior to vaccination

No

No

No

No

Onset post vaccine (days)

7

2–3

2

5

Symptoms

Pleuritic chest pain

Dyspnoea

Pleuritic chest pain

Dyspnoea

Chest pain

Palpitations

Dyspnoea

Dizziness

Headache

Fatigue

Chest pain

Palpitations

Dyspnoea

Dizziness

Examination

Reduced breath sounds

Normal

Normal

Normal

Troponin T/I (ng/L)

 < 3

4

522

349

NT-proBNP (ng/L)

–

 < 50

–

347

CRP (mg/L)

30.1

33.2

6

6.4

ECG

Diffuse upsloping ST elevation

Global ST elevation

PVCs

Anterior TWI

Sinus Bradycardia (43 bpm)

Anterior TWI

Echocardiogram

Normal

Normal

–

Normal

Cardiac MRI—Pre Vaccination

–

–

–

Normal (resolution of prior abnormalities)

Cardiac MRI—Post vaccination

–

–

LV and RV dilation

Myocardial and pericardial oedema

Trivial pericardial effusion

–

Brighton criteria level of certainty

Level 2—pericarditis

Level 2—pericarditis

Level 1—myocarditis

Level 2—myocarditis

Hospital presentation/Admission

1 day admission

Reviewed in ED

3 days admission

5 days admission

Management

Ibuprofen

Colchicine

Ibuprofen

Colchicine

Prednisolone

Bisoprolol

Prednisolone

Propranolol

Symptom duration

3 months

2 months

5 months

Ongoing