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  1. There is currently a dramatic increase in the number of COVID-19 cases worldwide, and further drastic restrictions in our daily life will be necessary to contain this pandemic. The implications of restrictive ...

    Authors: Nicole Maison, Heidrun Herbrüggen, Bianca Schaub, Christina Schauberger, Svenja Foth, Ruth Grychtol, Mustafa Abdo, Henrik Watz, Wilfried Nikolaizik, Klaus F. Rabe, Matthias V. Kopp, Gesine Hansen, Erika von Mutius, Thomas Bahmer and Jimmy Omony

    Citation: Allergy, Asthma & Clinical Immunology 2021 17:93

    Content type: Letter to the Editor

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  2. Allergen extracts used in subcutaneous immunotherapy can be standardized or non-standardized. Standardized extracts are available in specific biological potencies, presumably making their biological activity m...

    Authors: Benny Dua, Jane Park and Harold Kim

    Citation: Allergy, Asthma & Clinical Immunology 2021 17:92

    Content type: Research

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  3. An allergy to kiwi is rare in Poland. Most (65–72%) of the patients who are allergic to kiwi report symptoms of an oral allergy syndrome (OAS); however, systemic manifestations (18–28%) have also been reported.

    Authors: Natalia Ukleja-Sokołowska, Robert Zacniewski, Kinga Lis, Magdalena Żbikowska-Gotz, Andrzej Kuźmiński and Zbigniew Bartuzi

    Citation: Allergy, Asthma & Clinical Immunology 2021 17:91

    Content type: Case Report

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  4. Tocilizumab has been shown to be effective for treatment of juvenile idiopathic arthritis (JIA). To our knowledge, this is the first reported case of interstitial lung disease occurring shortly after tocilizum...

    Authors: Koichi Sugihara, Risa Wakiya, Hiromi Shimada, Mikiya Kato, Tomohiro Kameda, Shusaku Nakashima, Mai Mahmoud Fahmy Mansour, Yusuke Ushio, Norimitsu Kadowaki and Hiroaki Dobashi

    Citation: Allergy, Asthma & Clinical Immunology 2021 17:90

    Content type: Case Report

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  5. Exercise-induced anaphylaxis (EIA) is a rare and potentially life-threatening disorder that can develop independently without food ingestion. Cold drinks can also trigger symptoms in some patients with cold-in...

    Authors: Chikako Motomura, Koji Ide, Terufumi Shimoda and Hiroshi Odajima

    Citation: Allergy, Asthma & Clinical Immunology 2021 17:89

    Content type: Case Report

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  6. Toxic epidermal necrolysis (TEN)/Stevens–Johnson syndrome (SJS) is the spectrum of severe, acute, mucocutaneous, T-cell mediated delayed type IV hypersensitivity reaction and universally related to different d...

    Authors: Biniyam A. Ayele, Kemal Ali and Eliyas Mulatu

    Citation: Allergy, Asthma & Clinical Immunology 2021 17:88

    Content type: Case Report

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  7. A formulation of black cumin (Nigella sativa L.), licorice (Glycyrrhiza glabra L.), anise (Pimpinella anisum L.) and tea (Camellia sinensis (L.) Kuntze) (denoted BLAB tea) is traditionally used to relief allergy ...

    Authors: Chengsong Liao, Yangyang Han, Zhijing Chen and Huricha Baigude

    Citation: Allergy, Asthma & Clinical Immunology 2021 17:87

    Content type: Research

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  8. Increased intestinal permeability, either due to the exposure to antigens in asthmatic patients or due to a barrier defect, plays a critical role in susceptibility to environmental allergens. House dust mite a...

    Authors: Shereen A. Baioumy, Aya Elgendy, Shereen M. Ibrahim, Sara I. Taha and Shaimaa H. Fouad

    Citation: Allergy, Asthma & Clinical Immunology 2021 17:86

    Content type: Research

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  9. Leveraging the data management resources of the Canadian Primary Care Sentinel Surveillance Network (CPCSSN) is a viable approach for describing the prevalence of allergic disease documented in primary care se...

    Authors: Alexander G. Singer, Leanne Kosowan, Nerissa Nankissoor, Ryan Phung, Jennifer L. P. Protudjer and Elissa M. Abrams

    Citation: Allergy, Asthma & Clinical Immunology 2021 17:85

    Content type: Short Report

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  10. Physical effort is capable of triggering airway obstruction in asthmatics, the so-called exercise-induced bronchoconstriction in asthma (EIBa). This study was performed in subjects with mild persistent asthma,...

    Authors: Maroon Salameh, Laura Pini, Federico Quadri, Fabio Spreafico, Damiano Bottone and Claudio Tantucci

    Citation: Allergy, Asthma & Clinical Immunology 2021 17:84

    Content type: Research

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  11. Food ladders are clinical tools already widely used in Europe for food reintroduction in milk- and egg-allergic children. Previously developed milk and egg ladders have limited applicability to Canadian childr...

    Authors: Alanna Chomyn, Edmond S. Chan, Joanne Yeung, Timothy K. Vander Leek, Brock A. Williams, Lianne Soller, Elissa M. Abrams, Raymond Mak and Tiffany Wong

    Citation: Allergy, Asthma & Clinical Immunology 2021 17:83

    Content type: Letter to the Editor

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  12. The expression profiles of the intestinal mucosa have not been comprehensively investigated in asthma. We aimed to explore this in the Correlated Expression and Disease Association Research (CEDAR) patient coh...

    Authors: Jan K. Nowak, Marzena Dworacka, Nazgul Gubaj, Arystan Dossimov, Zhumabek Dossimov and Jarosław Walkowiak

    Citation: Allergy, Asthma & Clinical Immunology 2021 17:82

    Content type: Research

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  13. Drug reaction with eosinophilia and systemic symptoms (DRESS) is a potentially life-threatening hypersensitivity reaction to medication. While a relatively rare phenomenon, early identification and discontinua...

    Authors: Arman Zereshkian and Susan Waserman

    Citation: Allergy, Asthma & Clinical Immunology 2021 17:81

    Content type: Case Report

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  14. Allergic reaction to liposomal amphotericin B is rare. We report a case of cardiac arrest in a 64-year-old woman following liposomal amphotericin B infusion, requiring resuscitation. We also present the result...

    Authors: George P. Drewett, Ana Copaescu, Joseph DeLuca, Natasha E. Holmes and Jason A. Trubiano

    Citation: Allergy, Asthma & Clinical Immunology 2021 17:80

    Content type: Case Report

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  15. Insulin hypersensitivity is rare, but challenging for individuals with diabetes. The prevalence of insulin allergy has decreased since the introduction of human recombinant insulin preparations. Hypersensitivi...

    Authors: Babak Aberumand and Samira Jeimy

    Citation: Allergy, Asthma & Clinical Immunology 2021 17:79

    Content type: Case Report

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  16. Hereditary angioedema (HAE) is a rare autosomal dominant disease resulting in recurring episodes of swelling, leading to considerable patient morbidity and mortality. Lanadelumab is a plasma kallikrein inhibit...

    Authors: Aled Iaboni, Amin Kanani, Gina Lacuesta, Christine Song, Manstein Kan and Stephen D. Betschel

    Citation: Allergy, Asthma & Clinical Immunology 2021 17:78

    Content type: Letter to the Editor

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  17. Body mass index (BMI) is associated with asthma but associations of BMI temporal patterns with asthma incidence are unclear. Previous studies suggest that DNA methylation (DNAm) is associated with asthma statu...

    Authors: Rutu Rathod, Hongmei Zhang, Wilfried Karmaus, Susan Ewart, Latha Kadalayil, Caroline Relton, Susan Ring, S. Hasan Arshad and John W. Holloway

    Citation: Allergy, Asthma & Clinical Immunology 2021 17:77

    Content type: Research

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  18. Shrimp allergy is a growing problem among the European population. TSLP, IL-25 and IL-33 are involved in the pathophysiology of allergic diseases, including asthma and atopic dermatitis, as they activate the T...

    Authors: Natalia Ukleja-Sokołowska, Magdalena Żbikowska-Gotz, Kinga Lis, Rafał Adamczak and Zbigniew Bartuzi

    Citation: Allergy, Asthma & Clinical Immunology 2021 17:76

    Content type: Research

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  19. Currently, several biologics are used for the treatment of cutaneous pathologies such as atopic dermatitis (AD), psoriasis or skin cancers. The main administration routes are subcutaneous and intravenous injec...

    Authors: Audrey Baylet, Raoul Vyumvuhore, Marine Laclaverie, Laëtitia Marchand, Carine Mainzer, Sylvie Bordes, Brigitte Closs-Gonthier and Laurent Delpy

    Citation: Allergy, Asthma & Clinical Immunology 2021 17:73

    Content type: Short Report

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  20. We conducted a nationwide Canadian telephone survey on food allergy prevalence between February 2016 and January 2017, targeting vulnerable populations (New, Indigenous, and lower-income Canadians).

    Authors: Ann E. Clarke, Susan J. Elliott, Yvan St. Pierre, Lianne Soller, Sebastien La Vieille and Moshe Ben-Shoshan

    Citation: Allergy, Asthma & Clinical Immunology 2021 17:72

    Content type: Letter to the Editor

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  21. Most Canadian food allergy data has focused on Health Canada’s priority food allergens. This study describes which non-priority (emerging) food allergens were most commonly reported by Canadian parents and cat...

    Authors: Lianne Soller, Sebastien La Vieille, Scott B. Cameron, Raymond Mak, Victoria E. Cook, Jennifer Gerdts and Edmond S. Chan

    Citation: Allergy, Asthma & Clinical Immunology 2021 17:71

    Content type: Letter to the Editor

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  22. Glucocorticoids rarely cause anaphylaxis. Common methods for the determination of allergens include in vivo skin prick test (SPT) and intradermal skin test (IDST) and the in vitro basophil activation test (BAT...

    Authors: Hitomi Amano, Yoshiro Kitagawa, Tomohito Hayakawa, Taichiro Muto, Akihisa Okumura and Hideyuki Iwayama

    Citation: Allergy, Asthma & Clinical Immunology 2021 17:70

    Content type: Case Report

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  23. IL13, IL4, IL4RA, FCER1B and ADRB2 are susceptible genes of asthma and atopy. Our previous study has found gene–gene interactions on asthma between these genes in Chinese Han children. Whether the interactions be...

    Authors: Li Hua, Quanhua Liu, Jing Li, Xianbo Zuo, Qian Chen, Jingyang Li, Yuwei Wang, Haipei Liu, Zhaobo Shen, Yi Li, Zenan Ma, Shengdong Dong, Ruoxu Ji, Dingzhu Fang, Yi Chen, Wenwei Zhong…

    Citation: Allergy, Asthma & Clinical Immunology 2021 17:69

    Content type: Research

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  24. We recently showed that multicomponent traditional Chinese medicine (TCM) therapy had steroid-sparing effects in moderate-to-severe eczema. We sought to evaluate TCM effects in severe eczema in a 7-year-old ma...

    Authors: Serife Uzun, Zixi Wang, Tory A. McKnight, Paul Ehrlich, Erin Thanik, Anna Nowak-Wegrzyn, Nan Yang and Xiu-Min Li

    Citation: Allergy, Asthma & Clinical Immunology 2021 17:68

    Content type: Letter to the Editor

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  25. A significant portion of COVID-19 sufferers have asthma. The impacts of asthma on COVID-19 progression are still unclear but a modifying effect is plausible as respiratory viruses are acknowledged to be an imp...

    Authors: Jian Luo, Yi-Ling Chen, Wentao Chen, David A. Duncan, Alexander Mentzer, Julian C. Knight, Graham Ogg, Paul Klenerman, Ian D. Pavord and Luzheng Xue

    Citation: Allergy, Asthma & Clinical Immunology 2021 17:67

    Content type: Research

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  26. A cost-minimization analysis (CMA) was performed to evaluate the economic implications of introducing the SQ Tree sublingual immunotherapy (SLIT)-tablets marketed as ITULATEK® (Health Canada regulatory approva...

    Authors: Anne K. Ellis, Rémi Gagnon, Eva Hammerby, Julia Shen and Sheena Gosain

    Citation: Allergy, Asthma & Clinical Immunology 2021 17:66

    Content type: Research

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  27. Subcutaneous immunotherapy (SCIT) is an effective treatment for allergic rhinoconjunctivitis. However, adverse events, including life-threatening systemic reactions, may occur. The purpose of this project is t...

    Authors: Adam Aue, Joella Ho, Rongbo Zhu, Harold Kim and Samira Jeimy

    Citation: Allergy, Asthma & Clinical Immunology 2021 17:65

    Content type: Research

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  28. On Wright-stained sputum cytospins, eosinophil differential of ≥ 1.2% is considered abnormal, and ≥ 2.3% identifies an eosinophilic endotype. We hypothesized that failure to consider free eosinophil granules (...

    Authors: Melanie Kjarsgaard, Adil Adatia, Anurag Bhalla, Nicola LaVigne, Katherine Radford, Chynna Huang, Manali Mukherjee and Parameswaran Nair

    Citation: Allergy, Asthma & Clinical Immunology 2021 17:63

    Content type: Research

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  29. Inconsistencies remain regarding the effectiveness and safety of leukotriene receptor antagonists (LTRAs) and selective H1-antihistamines (SAHs) for allergic rhinitis (AR). A meta-analysis of randomized contro...

    Authors: Yan Feng, Ya-Ping Meng, Ying-Ying Dong, Chang-Yu Qiu and Lei Cheng

    Citation: Allergy, Asthma & Clinical Immunology 2021 17:62

    Content type: Review

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  30. While many studies of effective hereditary angioedema (HAE) therapy have demonstrated improved health-related quality of life (HRQoL) using validated instruments, specific reasons behind the improved scores ha...

    Authors: John Anderson, Donald S. Levy, William Lumry, Patricia Koochaki, Sally Lanar and H. Henry Li

    Citation: Allergy, Asthma & Clinical Immunology 2021 17:60

    Content type: Research

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  31. Allergic rhinitis (AR) is one of the most widespread immune conditions worldwide. However, common treatments often present with significant side effects or are cost-prohibitive for much of the population. A pl...

    Authors: Jing Zhou, Yi Lu, Wei Wu and Yunhai Feng

    Citation: Allergy, Asthma & Clinical Immunology 2021 17:59

    Content type: Research

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  32. Autoimmune progesterone dermatitis (APD) is a rare skin condition caused by sensitivity to high levels of progesterone secreted during the luteal phase of the menstrual cycle. This may be due to various pathop...

    Authors: Akshay Varghese, Terri Paul, Harold Kim, Stan Van Uum, Peter Vadas and Alescia Azzola

    Citation: Allergy, Asthma & Clinical Immunology 2021 17:58

    Content type: Case Report

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  33. The objective of this study was to determine primary prescription adherence for obstructive lung diseases (e.g., asthma, COPD) in an adult primary care patient population over a 3-year period.

    Authors: Alexander G. Singer, Alan Katz, Lisa LaBine, Lisa M. Lix, Marina Yogendran, Ian Sinha and Elissa M. Abrams

    Citation: Allergy, Asthma & Clinical Immunology 2021 17:57

    Content type: Short Report

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  34. Lymphocytic esophagitis is a newly recognized entity of unknown origin. Dysphagia is defined as difficulty swallowing and represents a common symptom in the general population with a prevalence of approximatel...

    Authors: O. Wojas, M. Żalikowska-Gardocka, E. Krzych-Fałta, B. Szczepankiewicz, P. Samel-Kowalik, B. Samoliński and A. Przybyłkowski

    Citation: Allergy, Asthma & Clinical Immunology 2021 17:56

    Content type: Case Report

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  35. The aim of this cross-sectional survey was to compare the health-economic consequences for allergic rhinitis (AR) patients treated with sublingual Immunotherapy (SLIT) in terms of direct and indirect costs wit...

    Authors: Petter Olsson, Carl Skröder, Lars Ahlbeck, Frida Hjalte, Karl-Olof Welin, Ulla Westin, Morgan Andersson, Cecilia Ahlström-Emanuelsson and Lars-Olaf Cardell

    Citation: Allergy, Asthma & Clinical Immunology 2021 17:55

    Content type: Research

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  36. While there exist case reports of anaphylaxis occurring during renal transplant surgery, descriptions of continuing transplant surgery post-anaphylaxis have been scarce. Anaphylactic reactions that present sol...

    Authors: Kaveh Hemati, Shelley Gierat, Garrett R. Roll and Odmara L. Barreto Chang

    Citation: Allergy, Asthma & Clinical Immunology 2021 17:54

    Content type: Case Report

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  37. Air pollution may be associated with increased airway responsiveness to allergens in allergic rhinitis (AR). Ozone-aged environmental black carbon (O3BC) is an important constituent of atmospheric particulate mat...

    Authors: Yuhui Ouyang, Ying Li, Zhaojun Xu, Yusan An and Luo Zhang

    Citation: Allergy, Asthma & Clinical Immunology 2021 17:52

    Content type: Research

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  38. Identification of molecular markers, such as miRNAs is promising for the diagnosis of asthma and its clinical phenotypes. The aim of this study was to examine the changes in the expression of selected microRNA...

    Authors: Mostafa Atashbasteh, Esmaeil Mortaz, Seyed Alireza Mahdaviani, Hamidreza Jamaati and Abdolamir Allameh

    Citation: Allergy, Asthma & Clinical Immunology 2021 17:51

    Content type: Research

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  39. A retrospective review of clinical manifestations and demographic pattern of patients diagnosed as chronic granulomatous disease (CGD) from 7 hospitals in Malaysia. An analysis of the available database would ...

    Authors: Lokman Mohd Noh, Amir Hamzah Abdul Latiff, Intan Hakimah Ismail, Rahim Md Noah, Asrul Abdul Wahab, Intan Juliana Abd. Hamid, Adiratna Mat Ripen, Nasuruddin B. Abdullah, Kamarul Azhar Razali, Norzila Zainudin, Florence Bakon, Long Juan Kok, Adli Ali, Bilkis Banu SAbd Aziz, Hasniah Abdul Latif, Siti Mardhiana Mohamad…

    Citation: Allergy, Asthma & Clinical Immunology 2021 17:50

    Content type: Research

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  40. Kimura’s disease (KD) is a rare chronic inflammatory disease of unknown etiology. Clinically, KD is characterized by nodular subcutaneous masses, that are typically localized to the neck and head. Involvement ...

    Authors: Keisuke Sugimoto, Takuji Enya, Yuichi Morimoto, Rina Oshima, Kohei Miyazaki and Mitsuru Okada

    Citation: Allergy, Asthma & Clinical Immunology 2021 17:48

    Content type: Case Report

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  41. There is a need to identify the asthma inflammatory phenotypes of patients to facilitate personalized asthma treatment. Sputum induction is time-consuming and requires expert clinical technique. This study aim...

    Authors: Bingqing Shi, Wei Li, Yuqiu Hao, Hongna Dong, Wenjing Cao, Jie Guo and Peng Gao

    Citation: Allergy, Asthma & Clinical Immunology 2021 17:47

    Content type: Research

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  42. Worldwide, allergy affects more than one billion people, with particularly rising prevalence in industrialised areas. Specifically, young adults appear to be predominantly targeted for an allergy diagnosis. Al...

    Authors: Hanna Danielewicz, Anna Dębińska, Grzegorz Myszczyszyn, Anna Myszkal, Lidia Hirnle, Anna Drabik-Chamerska, Danuta Kalita and Andrzej Boznański

    Citation: Allergy, Asthma & Clinical Immunology 2021 17:46

    Content type: Research

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  43. Investigating the endotypes of the different asthma phenotypes would help disease monitoring, prognosis determination, and improving asthma management standardization. This study aimed to classify asthma into ...

    Authors: Yi Jiang, Ruoli An, Li Cheng, Qianru Yue, Hanwei Zhang, Yali Zhang, Xiaomei Kong, Hongxia Ma, Fang Chen and Yufeng Guo

    Citation: Allergy, Asthma & Clinical Immunology 2021 17:45

    Content type: Research

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  44. Recent research has pointed out the important roles of epigenetic modifications in the development and persistence of allergic rhinitis (AR), especially in relation to DNA methylation of disease-associated gen...

    Authors: Yu Zhang, Meiyu Tan, Xiaoqiong Qian, Cong Li, Lei Yue, Yuehong Liu and Song Shi

    Citation: Allergy, Asthma & Clinical Immunology 2021 17:44

    Content type: Research

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