Articles

Genetic polymorphisms in vitamin D pathway influence 25(OH)D levels and are associated with atopy and asthma

Vitamin D deficiency or insufficiency, has been associated with atopy and lack of asthma control. Our objective was to investigate associations between variants in genes of vitamin D pathway with serum levels ...

Authors: Alana Alcântara Galvão, Flávia de Araújo Sena, Emília Maria Medeiros de Andrade Belitardo, Maria Borges Rabelo de Santana, Gustavo Nunes de Oliveira Costa, Álvaro Augusto Cruz, Maurício Lima Barreto, Ryan dos Santos Costa, Neuza Maria Alcantara-Neves and Camila Alexandrina Figueiredo

Th17/Treg imbalance is associated with reduced indoleamine 2,3 dioxygenase activity in childhood allergic asthma

The differentiation of CD4+ lymphocytes Th17/regulatory T cells (Treg) and indoleamine 2,3-dioxygenase (IDO) is associated with the pathogenesis of allergic asthma. Basic research has shown that IDO is likely ...

Authors: Ying Hu, Zhiqiang Chen, Jing Zeng, Shouyan Zheng, Liujuan Sun, Li Zhu and Wei Liao

Facial erythema after the treatment of dupilumab in SLE patient

Dupilumab is a receptor antagonist binding to the alpha subunit of the interleukin-4 receptor. Through binding to it, dupilumab inhibits signaling of both IL-4 and IL-13, the representative Th2 biomarkers. Rec...

Authors: Dong Hyek Jang, Jae In Lee, Joo Yoon Bae, Hye Jung Jung, Mi Yeon Park and Jiyoung Ahn

Inhalation of nebulized Mycobacterium vaccae can protect against allergic bronchial asthma in mice by regulating the TGF-β/Smad signal transduction pathway

Mycobacterium vaccae nebulization imparted protective effect against allergic asthma in a mouse model. The TGF-β/Smad signal transduction pathway plays an important role in allergic bronchial asthma. However, the...

Authors: Xiao-hong Jiang, Chao-qian Li, Guang-yi Feng, Ming-jie Luo and Qi-xiang Sun

Comparison of allergens and symptoms in patients with allergic rhinitis between 1990s and 2010s

The prevalence of allergic rhinitis (AR), an environment- and lifestyle-dependent condition, has been constantly increasing in Korea. Although the environment and lifestyle of the Korean people have recently u...

Authors: Ji Heui Kim, Shin Ae Kim, Ja Yoon Ku, Won Ki Cho and Chol Ho Shin

Sensitivity and specificity of double-blinded penicillin skin testing in relation to oral provocation with amoxicillin in children

Current recommendations for the management of penicillin allergy are to perform penicillin skin testing (PST) with penicilloyl-polylysine (PPL) and benzylpenicillin (BP) prior to drug challenge with amoxicilli...

Authors: Roxane Labrosse, Louis Paradis, Kathryn Samaan, Jonathan Lacombe-Barrios, Jean Paradis, Philippe Bégin and Anne Des Roches

Type I allergic reaction to rituximab upon first lifetime exposure: a case report

While drug reactions to rituximab have been commonly reported in the literature, a type I allergic reaction to rituximab after first lifetime exposure has never been reported.

Authors: V. Polito, A. Barbacki and G. Isabwe

Differential response to biologics in a patient with severe asthma and ABPA: a role for dupilumab?

Allergic bronchopulmonary aspergillosis (ABPA) is a severe hypersensitivity reaction to aspergillus species colonizing the airways of patients with asthma or cystic fibrosis. Biologics including anti-IgE and a...

Authors: Carlo Mümmler, Bernd Kemmerich, Jürgen Behr, Nikolaus Kneidinger and Katrin Milger

Incidence of malignancy in patients with common variable immunodeficiency according to therapeutic delay: an Italian retrospective, monocentric cohort study

Common variable immunodeficiency (CVID) is the most common symptomatic primary immunodeficiency and has a broad spectrum of clinical manifestations. Among non-infectious complications, an increased incidence o...

Authors: Veronica Pedini, Jacopo Umberto Verga, Irene Terrenato, Denise Menghini, Cristina Mezzanotte and Maria Giovanna Danieli

An emerging allergen: Cannabis sativa allergy in a climate of recent legalization

Considering its recent legalization in Canada, the health implications of Cannabis sativa exposure, including allergy, are coming to the forefront of medical study and interest. C. sativa allergy is an issue that...

Authors: Bradley Jackson, Erica Cleto and Samira Jeimy

Proceedings of the Canadian Society of Allergy and Clinical Immunology Annual Scientific Meeting 2019

Authors:

Asthma increases the risk of herpes zoster: a nested case–control study using a national sample cohort

This study aimed to complement previous studies on the risk of herpes zoster in the asthmatic adult population.

Authors: So Young Kim, Dong Jun Oh and Hyo Geun Choi

Anaphylaxis to clindamycin following cutaneous exposure

The role and importance of skin barrier as an immunologic organ and as a potent way of sensitization is well known. However, antibiotics anaphylaxis following skin sensitization has not been reported.

Authors: N. Paradis, L. Marois, L. Paradis, F. Graham, P. Bégin and A. Des Roches

Serum BPI as a novel biomarker in asthma

Neutrophils, eosinophils and inflammatory cells contribute to asthmatic inflammation. The anti-bactericidal/permeability-increasing protein (BPI), produced by neutrophils, peripheral blood monocytes or epithel...

Authors: Chen Xingyuan and Qiu Chen

Efficacy of omalizumab in children, adolescents, and adults with severe allergic asthma: a systematic review, meta-analysis, and call for new trials using current guidelines for assessment of severe asthma

Omalizumab is approved for treating severe allergic asthma from age 6, but the definition of severe asthma including a systematic assessment to rule out difficult-to-treat asthma has changed since the drug was...

Authors: Daniel P. Henriksen, Uffe Bodtger, Kirsten Sidenius, Niels Maltbaek, Lars Pedersen, Hanne Madsen, Ehm A. Andersson, Ole Norgaard, Louise K. Madsen and Bo L. Chawes

A rare case of anaphylaxis to Indian jujube (Ziziphus Mauritiana Lam)

Indian jujube (Ziziphus Mauritiana Lam) is a sweet fruit from a tree native to tropical and subtropical regions of Asia and India. A few case reports have implicated Indian jujube to cause latex-fruit syndrome. W...

Authors: Babak Aberumand and Rozita Borici-Mazi

Anaphylaxis to three humanized antibodies for severe asthma: a case study

Omalizumab, mepolizumab, benralizumab, and dupilumab are the currently available biologics used to treat asthma in Japan. Anaphylaxis following treatment with mepolizumab or benralizumab is considered rare.

Authors: Koichi Jingo, Norihiro Harada, Toshihiko Nishioki, Masahiro Torasawa, Tomoko Yamada, Tetsuhiko Asao, Haruhi Takagi, Tomohito Takeshige, Jun Ito and Kazuhisa Takahashi

Effects of MP-AzeFlu enhanced by activation of bitter taste receptor TAS2R

MP-AzeFlu is relatively new a pharmaceutical drug used in the treatment of allergic rhinitis. It is comprised of azelastine hydrochloride (AZE), a potent histamine-H1-receptor antagonist and fluticasone propio...

Authors: Sandra Ekstedt, Susanna Kumlien Georén and Lars Olaf Cardell

Season of birth is associated with increased risk of atopic dermatitis in Japanese infants: a retrospective cohort study

Several epidemiological studies have examined the possibility of a relationship between season of birth and atopic dermatitis (AD) and food allergy (FA), yet their results are contradictory. We investigated th...

Authors: Yu Kuwabara, Ritsue Nii, Keiko Tanaka, Eiichi Ishii, Mizuho Nagao and Takao Fujisawa

Tonsillar granuloma associated with hypogammaglobulinemia

Rare tonsillar granulomas may be caused for example by infections, malignancies or sarcoidosis. Granulomas also occur in inborn errors of immunity (IEI) such as common variable immunodeficiency (CVID) with B c...

Authors: Aleksi Laajala, Outi Kuismin, Mikko Tastula, Leena Tiitto, Saila Kauppila, Anna Salo, Pirjo Åström, Antti Nissinen, Virpi Glumoff, Mikko R. J. Seppänen and Timo Hautala

Hereditary angioedema C1-esterase inhibitor replacement therapy and coexisting autoimmune disorders: findings from a claims database

In this letter to the editor, we present results of claims data analysis. This claims data analysis supports a hypothesis that in patients with hereditary angioedema due to C1-esterase inhibitor (C1-INH) defic...

Authors: Henriette Farkas, Donald Levy, Dylan Supina, Melvin Berger, Subhransu Prusty and Moshe Fridman

Co-occurrence between C1 esterase inhibitor deficiency and autoimmune disease: a systematic literature review

Hereditary angioedema (HAE) is caused by a SERPING1 gene defect resulting in decreased (Type I) or dysfunctional (Type II) C1 esterase inhibitor (C1-INH). The prevalence of autoimmune diseases (ADs) in patient...

Authors: Donald Levy, Timothy Craig, Paul K. Keith, Girishanthy Krishnarajah, Rachel Beckerman and Subhransu Prusty

Epidermal growth factor upregulates expression of MUC5AC via TMEM16A, in chronic rhinosinusitis with nasal polyps

Mucus hypersecretion and goblet cell upregulation are common features of chronic rhinosinusitis with nasal polyps (CRSwNP). Although epidermal growth factor (EGF) has been reported to stimulate the expression ...

Authors: Jian Jiao, Tao Zhang, Yu Zhang, Jingyun Li, Min Wang, Ming Wang, Ying Li, Xiangdong Wang and Luo Zhang

Towards definitive management of allergic rhinitis: best use of new and established therapies

Allergic rhinitis (AR) is an inflammatory disease of the nasal mucosa impacting up to 25% of Canadians. The standard of care for AR includes a treatment plan that takes into account patient preferences, the se...

Authors: Lubnaa Hossenbaccus, Sophia Linton, Sarah Garvey and Anne K. Ellis

Correction to: Protocol for a double-blind, randomized controlled trial on the dose-related efficacy of omalizumab in multi-food oral immunotherapy

An amendment to this paper has been published and can be accessed via the original article.

Authors: Alexandra Langlois, Marie-Hélène Lavergne, Hélène Leroux, Kerstin Killer, Pauline Azzano, Louis Paradis, Kathryn Samaan, Jonathan Lacombe-Barrios, Thomas Eiwegger, Julia Upton, Gordon Sussman, Thomas Poder, Benoît Mâsse, Anne Des Roches and Philippe Bégin

Assessment of clinical activity and severity using serum ANCA and ASCA antibodies in patients with ulcerative colitis

Ulcerative colitis (UC) is a chronic, non-specific inflammatory bowel disease (IBD) with unknown etiology. The lack of specific clinical manifestations, standard diagnostic criteria, objective and accurate ind...

Authors: Yanhua Pang, Huijie Ruan, Dongfang Wu, Yanfei Lang, Ke Sun and Cuiping Xu

Quercetin with the potential effect on allergic diseases

Quercetin is a naturally occurring polyphenol flavonoid which is rich in antioxidants. It has anti-allergic functions that are known for inhibiting histamine production and pro-inflammatory mediators. Querceti...

Authors: Morteza Jafarinia, Mahnaz Sadat Hosseini, Neda kasiri, Niloofar Fazel, Farshid Fathi, Mazdak Ganjalikhani Hakemi and Nahid Eskandari

Increasing allergy: are antibiotics the elephant in the room?

Antibiotics cause dramatic changes to the human microbiome. The composition of the microbiome has been associated with changes in the immune system and these changes are beginning to be linked to immune diseas...

Authors: Rod A. Herman

Delivery of subcutaneous immunoglobulin by rapid “push” infusion for primary immunodeficiency patients in Manitoba: a retrospective review

Both intravenous and subcutaneous human immune globin G (IgG) replacement (IVIG and SCIG, respectively) reduce severe infection and increase serum IgG levels in primary immune deficiency disorder (PIDD) patien...

Authors: Graham Walter, Chrystyna Kalicinsky, Richard Warrington, Marianne Miguel, Jeannette Reyes and Tamar S. Rubin

Correction to: The International/Canadian Hereditary Angioedema Guideline

An amendment to this paper has been published and can be accessed via the original article.

Authors: Stephen Betschel, Jacquie Badiou, Karen Binkley, Rozita Borici-Mazi, Jacques Hébert, Amin Kanani, Paul Keith, Gina Lacuesta, Susan Waserman, Bill Yang, Emel Aygören-Pürsün, Jonathan Bernstein, Konrad Bork, Teresa Caballero, Marco Cicardi, Timothy Craig…

Lemon seed allergy: a case presentation

We report a case of IgE-mediated hypersensitivity to lemon seed. We demonstrate for the first time a pattern of cross-sensitisation between seeds of citrus hybrid species from similar ancestral species origins.

Authors: O. Stephanie Kayode, Nuevalynne Prado, David J. Thursfield, Stephen J. Till and Leonard Q. C. Siew

A preseason booster prolongs the increase of allergen specific IgG4 levels, after basic allergen intralymphatic immunotherapy, against grass pollen seasonal allergy

Allergen specific IgG4 levels have been monitored as a surrogate marker for the tolerance inducing effect of subcutaneous immunotherapy (SCIT) in many studies. Its accuracy at group level has been well establi...

Authors: Dan Weinfeld, Ulla Westin, Laila Hellkvist, Ulf-Henrik Mellqvist, Ingvar Jacobsson and Lars-Olaf Cardell

Local eosinophils are associated with increased IgA subclass levels in the sinonasal mucosa of chronic rhinosinusitis with polyp patients

Chronic rhinosinusitis (CRS) describes an inflammatory condition affecting the sinonasal mucosa. As the immune system players such as immunoglobulins play prominent roles in the development of CRS, we aimed to...

Authors: Hossein Aazami, Farhad Seif, Babak Ghalehbaghi, Pegah Babaheidarian, Alireza Mohebbi, Aslan Ahmadi, Majid Khoshmirsafa, Sahand Ghalehbaghi, Babak Behnam, Kobra Zinat Entezami, Zahra Madjd and Reza Falak

Higher efficacy of rupatadine 20 mg and 10 mg versus placebo in patients with perennial allergic rhinitis: a pooled responder analysis

The clinical efficacy of rupatadine in terms of responders has not been previously explored in perennial allergic rhinitis (PAR).

Authors: Antonio Valero, Iñaki Izquierdo, Marek L. Kowalski, Glenis K. Scadding, Jean Bousquet and Joaquim Mullol

Billing fees for various common allergy tests vary widely across Canada

The prevalence of food allergy in Canada is high and has increased over time. To date, there are no Canadian data on the healthcare costs of visits to allergists.

Authors: Jennifer Lisa Penner Protudjer, Lianne Soller, Elissa Michelle Abrams and Edmond S. Chan

Severe eosinophilic asthma and aspirin-exacerbated respiratory disease associated to eosinophilic gastroenteritis treated with mepolizumab: a case report

Mepolizumab (MEP) is the first anti Interleukin (IL)-5 add-on therapy approved for the treatment of severe refractory eosinophilic asthma.

Authors: C. Caruso, S. Colantuono, D. Pugliese, C. Di Mario, B. Tolusso, E. Gremese, G. Papparella, F. Castrì, A. Gasbarrini, A. Romano and A. Armuzzi

In patients with severe asthma with eosinophilia in reslizumab clinical trials, high peripheral blood eosinophil levels are associated with low FEV₁ reversibility

A post hoc analysis of two randomized, placebo–controlled, Phase 3 trials of intravenous reslizumab, an anti-interleukin-5 (IL-5) biologic for severe eosinophilic asthma.

Authors: J. Christian Virchow, Lisa Hickey, Evelyn Du and Margaret Garin

Protocol for a double-blind, randomized controlled trial on the dose-related efficacy of omalizumab in multi-food oral immunotherapy

Previous proof-of-concept studies have shown that a short course of omalizumab can safely accelerate the oral immunotherapy schedule for multiple allergens simultaneously. Considering the high cost of medicati...

Authors: Alexandra Langlois, Marie-Hélène Lavergne, Hélène Leroux, Kerstin Killer, Pauline Azzano, Louis Paradis, Kathryn Samaan, Jonathan Lacombe-Barrios, Thomas Eiwegger, Julia Upton, Gordon Sussman, Thomas Poder, Benoît Mâsse, Anne Des Roches and Philippe Bégin

Epinephrine auto-injector needle length

Epinephrine auto-injectors are expected to deliver the drug intramuscularly.

Authors: Sten Dreborg, Gina Tsai and Harold Kim

A case of allergy to Silybum marianum (milk thistle) and Eragrostis tef (teff)

This paper presents a peculiar first case of an allergy to Silybum marianum (milk thistle) and Eragrostis tef (teff). Both teff and milk thistle have been presented in the literature (both domestic and foreign...

Authors: O. Wojas, E. Krzych-Fałta, P. Samel-Kowalik, M. Żalikowska-Gardocka, E. Majsiak, A. Mari and B. Samoliński

Activated phosphoinositide 3-kinase delta syndrome 1 and 2 (APDS 1 and APDS 2): similarities and differences based on clinical presentation in two boys

Activated PI3K delta syndrome (APDS) belongs to the heterogeneous group of primary immunodeficiency disorders (PIDs). Progress in next-generation sequencing (NGS) enabled identification of gain-of-function mut...

Authors: Marlena Ewertowska, Elżbieta Grześk, Anna Urbańczyk, Anna Dąbrowska, Katarzyna Bąbol-Pokora, Monika Łęcka and Sylwia Kołtan

The presence of overlapping quality of life symptoms in primary antibody deficiency (PAD) and chronic fatigue syndrome (CFS)

Fatigue, sleep disturbance and altered mood are frequently reported in patients with primary antibody deficiency syndrome (PADS) on adequate immunoglobulin replacement therapy. This study aimed to determine th...

Authors: Rhea A. Bansal, Susan Tadros and Amolak S. Bansal

CSACI guidelines for the ethical, evidence-based and patient-oriented clinical practice of oral immunotherapy in IgE-mediated food allergy

Oral immunotherapy (OIT) is an emerging approach to the treatment of patients with IgE-mediated food allergy and is in the process of transitioning to clinical practice.

Authors: P. Bégin, E. S. Chan, H. Kim, M. Wagner, M. S. Cellier, C. Favron-Godbout, E. M. Abrams, M. Ben-Shoshan, S. B. Cameron, S. Carr, D. Fischer, A. Haynes, S. Kapur, M. N. Primeau, J. Upton, T. K. Vander Leek…

Hooked epinephrine auto-injector devices in children: four case reports with three different proposed mechanisms

The prevalence of epinephrine auto-injectors (EAI) use is on the rise. Our objective was to describes children with hooked EAI needles that were embedded in soft tissues.

Authors: Ran D. Goldman, Katharine C. Long and Julie C. Brown

Relationship between serum inhibitory activity for IgE and efficacy of Artemisia pollen subcutaneous immunotherapy for allergic rhinitis: a preliminary self-controlled study

Biomarkers of clinical efficacy for subcutaneous immunotherapy (SCIT) on allergic rhinitis (AR) have not been identified yet. This study aims to assess the clinical relevance of serum inhibitory activity for I...

Authors: Wenping Wang, Jinshu Yin, Xueyan Wang, Tingting Ma, Tianfei Lan, Qingkun Song and Yifan Guo

Food allergy among university students: uncharted territory

Food allergy is a growing global health concern, with limited studies conducted in developing countries. High-risk behavior regarding allergies is common among young adults, making them prone to severe allergi...

Authors: Ali Hassan, Amna Alsaihati, Malak Al Shammari, Haitham Alaithan, Wejdan Al-Johani, Nouf AlShamlan and Salman Aljubran

Factors related to poor adherence in Latvian asthma patients

The problem of nonadherence to therapy is a key reason of insufficient asthma control. Evaluating the beliefs about asthma medication, cognitive and emotional perceptions may help to identify patients with poo...

Authors: Dins Smits, Girts Brigis, Jana Pavare, Inga Urtane, Sandis Kovalovs and Noël Christopher Barengo

Patient and physician perceptions of seasonal allergic rhinitis and allergen immunotherapy: a parallel physician patient survey

The Allergy Patient Identification for Immunotherapy (AsPIRe) program was a parallel physician and patient survey. The objectives were to examine physician and patient perceptions of seasonal allergy symptoms ...

Authors: Anne K. Ellis, Jean Boursiquot, Stuart Carr, François Graham and Marie-Soleil Masse

Comparison of methacholine and mannitol challenges: importance of method of methacholine inhalation

Direct inhalation challenges (e.g. methacholine) are stated to be more sensitive and less specific for a diagnosis of asthma than are indirect challenges (e.g. exercise, non-isotonic aerosols, mannitol, etc.)....

Authors: Donald W. Cockcroft, Beth E. Davis and Christianne M. Blais

Replication study of susceptibility variants associated with allergic rhinitis and allergy in Han Chinese

Allergic rhinitis (AR) is believed to be a complex genetic disease. The last decade has been marked by the publication of more than 20 genome-wide association studies (GWASs) of AR and associated allergic phen...

Authors: Yunbo Gao, Jingyun Li, Yuan Zhang and Luo Zhang