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  1. Although the prevalence of allergic diseases, including food allergies, has increased over recent decades, relevant information on this topic is still lacking, particularly in younger children living in small ...

    Authors: José A. da S. Correia, Adriana Azoubel Antunes, Luiz Taborda-Barata, José Laerte Boechat and Emanuel Sávio Cavalcanti Sarinho
    Citation: Allergy, Asthma & Clinical Immunology 2022 18:74
  2. Constipation has been hypothesized to be associated with the increased risk of wheezing or asthma. However, the relation remains a subject of debate. We conducted this meta-analysis to assess whether constipat...

    Authors: Lu Liu, Xiangli Zhang, Zhengdong Jiang, Guizuo Wang, Hua Wu, Ruilin Chen, Yongqing Zhang, Manxiang Li and Shumei Yang
    Citation: Allergy, Asthma & Clinical Immunology 2022 18:73
  3. We compared patient and caregiver knowledge and confidence for managing asthma, and participant experiences when comprehensive asthma education was delivered in person versus in the virtual setting.

    Authors: Dhenuka Radhakrishnan, Andrea Higginson, Madhura Thipse, Marc Tessier and Arun Radhakrishnan
    Citation: Allergy, Asthma & Clinical Immunology 2022 18:72
  4. Our recent observational study showed that regular consumption of cow’s milk (CM) formula during early infancy (3–6 months old) was associated with a reduced risk of CM allergy (CMA) at 12 months old. However,...

    Authors: Kota Ikari, Junichiro Tezuka, Masafumi Sanefuji, Jiro Nakayama, Daisuke Nishima, Yuri Sonoda, Masanobu Ogawa, Masayuki Shimono, Reiko Suga, Satoshi Honjo, Koichi Kusuhara and Shouichi Ohga
    Citation: Allergy, Asthma & Clinical Immunology 2022 18:71
  5. Real-world data on transitioning to Immune Globulin Subcutaneous (Human) 20% solution (Ig20Gly) are limited. This study aimed to assess infusion parameters and experience of patients with primary (PID) or seco...

    Authors: Paul K. Keith, Juthaporn Cowan, Amin Kanani, Harold Kim, Gina Lacuesta, Jason K. Lee, Jie Chen, Michelle Park and André Gladiator
    Citation: Allergy, Asthma & Clinical Immunology 2022 18:70
  6. Drug-induced hypersensitivity syndrome (DIHS) is a rare, potentially life-threatening systemic drug reaction. Antithyroid drugs (ATDs) causing DIHS have seldom been reported before.

    Authors: Fang Wu, Ting Jin, Chengxin Shang, Xihua Lin, Xiaoqin Gong and Zhou Wang
    Citation: Allergy, Asthma & Clinical Immunology 2022 18:69
  7. Ear, nose, and throat involvement are common in eosinophilic granulomatosis with polyangiitis (EGPA). Among otologic manifestation, middle ear effusion (MEE) is less recognized but a problematic condition as i...

    Authors: Noeul Kang, Joongbo Shin, Yang-Sun Cho, Jin-Young Lee, Byung-Jae Lee and Dong-Chull Choi
    Citation: Allergy, Asthma & Clinical Immunology 2022 18:68
  8. Olfactory dysfunction is recognized as a symptom of COVID-19. Reports revealed the nasal calcium increase has adverse effects on olfactory function. Tetra sodium pyrophosphate, a chelating agent, can bind calc...

    Authors: Mohamed H. Abdelazim, Ahmed H. Abdelazim and Waleed Moneir
    Citation: Allergy, Asthma & Clinical Immunology 2022 18:67
  9. Several miRNAs are now known to have clear connections to the pathogenesis of asthma. The present study focused on the potential role of miR-3934 during asthma development.

    Authors: Liyan Dou, Wenyu Wang, Junwei Wang, Xiaofei Zhang, Xiaoman Hu, Weili Zheng, Kaiyu Han and Guangyou Wang
    Citation: Allergy, Asthma & Clinical Immunology 2022 18:66
  10. Authors: Ignacio J. Ansotegui, Jonathan A. Bernstein, Giorgio W. Canonica, Sandra N. Gonzalez-Diaz, Bryan L. Martin, Mario Morais-Almeida, Margarita Murrieta-Aguttes and Mario Sanchez Borges
    Citation: Allergy, Asthma & Clinical Immunology 2022 18:65

    The original article was published in Allergy, Asthma & Clinical Immunology 2022 18:41

  11. Hereditary angioedema (HAE) is a rare, autosomal disorder that manifests with unpredictable episodes of severe swelling of the skin and mucous membranes. These attacks can be highly disfiguring and range in se...

    Authors: Florence Ida Hsu, William Lumry, Marc Riedl and Raffi Tachdjian
    Citation: Allergy, Asthma & Clinical Immunology 2022 18:64

    The Correction to this article has been published in Allergy, Asthma & Clinical Immunology 2022 18:81

  12. Allergen immunotherapy (AIT) is the only treatment that has modified the natural history of allergic diseases. However, since its overall effect on the immune system has not been elucidated, AIT is either abso...

    Authors: Kazuki Fujioka, Akiko Kasahara, Takashi Kida, Wataru Fujii, Takahiro Seno, Makoto Wada, Masataka Kohno and Yutaka Kawahito
    Citation: Allergy, Asthma & Clinical Immunology 2022 18:63
  13. Owing to a collaborative approach to patient care, and a paucity of allergists in Canada, there is a need to develop a food allergy educational program for allied health care professionals in Canada. Such prog...

    Authors: Jennifer L. P. Protudjer, Carina Venter, Marion Groetch, Tara Lynn Mary Frykas, Jasmin Lidington and Harold Kim
    Citation: Allergy, Asthma & Clinical Immunology 2022 18:62
  14. Wheat-dependent exercise-induced anaphylaxis (WDEIA) is a serious and potentially life-threatening form of wheat allergy. Further episodes can only be prevented by avoiding wheat ingestion or avoiding exercise...

    Authors: Zhirong Du, Xiang Gao, Junda Li, Lun Li, Juan Liu and Jia Yin
    Citation: Allergy, Asthma & Clinical Immunology 2022 18:61
  15. Hereditary angioedema (HAE) is a rare, life-threatening disease. The knowledge about the molecular pathogenesis of HAE has derived mainly from investigating blood samples. However, limited data are available o...

    Authors: Henriette Farkas, Csilla Máj, István Kenessey, Anna Sebestyén, Ildikó Krencz, Judit Pápay and László Cervenak
    Citation: Allergy, Asthma & Clinical Immunology 2022 18:60
  16. Allergies, including food allergies, are a considerable clinical and public-health problem. The introduced preventive measures and differential diagnostics, including oral food challenges, are the gold standar...

    Authors: Edyta Krzych-Fałta, Oksana Wojas, Piotr Samel-Kowalik, Adam J. Sybilski and Bolesław Samoliński
    Citation: Allergy, Asthma & Clinical Immunology 2022 18:59
  17. Kimura disease (KD) is a rare chronic idiopathic condition of unknown etiology that is prevalent in Asian males. It often causes subcutaneous lumps and enlarged lymph nodes, especially in head and neck region....

    Authors: Ruiyun Fan, Guopeng Xu, Ying Chen, Jinghuan Lv and Zhongwei Zhang
    Citation: Allergy, Asthma & Clinical Immunology 2022 18:58
  18. The mechanism of action behind anaphylactic reactions to the mRNA COVID-19 vaccines remains unknown, but the excipient polyethylene glycol, PEG-2000, has been implicated. Initial recommendations were made for ...

    Authors: Daniel H. Li, Erika Lee and Christine Song
    Citation: Allergy, Asthma & Clinical Immunology 2022 18:57
  19. Air pollution may induce or reinforce nasal inflammation regardless of allergy status. There is limited direct clinical evidence informing the treatment of airborne pollution-related rhinitis.

    Authors: Yuan Zhang, Chunguang Shan, Weiwei Liu, Yaozhong Han, Guanggang Shi, Yongjian Ma, Kerstin Wagner, Xiaoyan Tian, Lili Zhang, Allan Joseph Larona, Steven Sacavage, Kathleen Franklin, Chengshuo Wang and Luo Zhang
    Citation: Allergy, Asthma & Clinical Immunology 2022 18:56
  20. The microtubule-dependent molecular motor protein Kinesin Family Member 2A (KIF2A) is down-regulated in asthmatic human airway epithelium. However, little is known about the roles of KIF2A as well as the possi...

    Authors: Zhengxia Wang, Jingjing Wu, Jingxian Jiang, Qiyun Ma, Meijuan Song, Tingting Xu, Yanan Liu, Zhongqi Chen, Yanmin Bao, Mao Huang, Mingshun Zhang and Ningfei Ji
    Citation: Allergy, Asthma & Clinical Immunology 2022 18:55
  21. Food protein-induced enterocolitis syndrome is a non-IgE-mediated reaction to food that is poorly understood, and underdiagnosed. Trigger foods can belong to any food group, but are most commonly milk, soy, ri...

    Authors: Samantha Wong, Lucy Duan, Alana Galper, Adelle Atkinson, Julia Upton and Thomas Eiwegger
    Citation: Allergy, Asthma & Clinical Immunology 2022 18:54
  22. Public health measures to mitigate the COVID-19 pandemic have altered health care for chronic conditions. The impact of the COVID-19 pandemic on paediatric asthma, the most common chronic respiratory cause of ...

    Authors: Nusrat Homaira, Nan Hu, Louisa Owens, Mei Chan, Melinda Gray, Philip N Britton, Hiran Selvadurai, Raghu Lingam and Adam Jaffe
    Citation: Allergy, Asthma & Clinical Immunology 2022 18:53
  23. Platelet-activating factor (PAF) has been suggested to be a potent inflammatory mediator in Allergic rhinitis (AR) pathogenesis. Vitamin E, an essential nutrient that comprises tocopherol and tocotrienol, is k...

    Authors: Cheryl Wei Ling Teo, Stephanie Jia Ying Png, Yee Wei Ung and Wei Ney Yap
    Citation: Allergy, Asthma & Clinical Immunology 2022 18:52
  24. A food ladder is a form of home-based dietary advancement therapy that gradually increases exposure to an allergenic food through the gradual introduction of egg or milk containing food with increasing quantit...

    Authors: Gilbert T. Chua, Edmond S. Chan, Joanne Yeung, Scott B. Cameron, Lianne Soller, Brock A. Williams, Alanna Chomyn, Timothy K. Vander Leek, Elissa M. Abrams, Raymond Mak and Tiffany Wong
    Citation: Allergy, Asthma & Clinical Immunology 2022 18:51
  25. 22q11.2 Deletion Syndrome (22q11.2DS) can result in array of congenital abnormalities including immune dysfunction. International guidelines recommend immune evaluation of 22q11.2DS patients prior to live vacc...

    Authors: Sophie McGregor, Matthew Boroditsky, Geraldine Blanchard-Rohner, Christine Loock and Kyla Jade Hildebrand
    Citation: Allergy, Asthma & Clinical Immunology 2022 18:50
  26. The Rosaceae family includes fruits, such as peach, apple, Japanese apricot, cherry (Prunoideae subfamily), and strawberry (Rosoideae subfamily). The allergens responsible for Rosaceae fruit allergies have bee...

    Authors: Chisato Inuo, Fumiko Okazaki, Rie Shiraki, Yutaka Tanaka, Keiko Momma, Yasuto Kondo and Hiroshi Narita
    Citation: Allergy, Asthma & Clinical Immunology 2022 18:49
  27. Patients with asthma frequently over rely on short-acting beta-agonists (SABA) to treat acute symptoms. This can adversely impact quality of life and increase the risk of exacerbations. SABA overuse is also as...

    Authors: Anne K. Ellis, Vanessa Foran, Alan Kaplan and Patrick D. Mitchell
    Citation: Allergy, Asthma & Clinical Immunology 2022 18:48
  28. The entire school community contributes to the safety of students with food allergy. We sought to determine the food allergy perceptions and education needs of parents, students and school staff, with the goal...

    Authors: Nancy Ross, Sandra Dalke, Shauna Filuk, Bev Kulbaba, Diane Marks, Jo-Anne St-Vincent and Elinor Simons
    Citation: Allergy, Asthma & Clinical Immunology 2022 18:47
  29. Human inborn errors of immunity (IEI) are a group of inherited genetic disorders of the immune system. IEI Patients suffer from severe repeated infections, autoimmunity, lymphadenopathy and/or increased suscep...

    Authors: Safa Meshaal, Rabab EI Hawary, Alia Eldash, Aya Erfan, Dalia Abd Elaziz, Radwa Alkady, Sohilla Lotfy, Nermeen Galal, Jeannette Boutros and Aisha Elmarsafy
    Citation: Allergy, Asthma & Clinical Immunology 2022 18:45
  30. Specific immunotherapy for patients with honey bee hypersensitivity is commonly applied. Re-challenge with venom is performed to prove protection in individual cases.

    Authors: Sara Micaletto, Kurt Ruetzler, Martin Bruesch and Peter Schmid-Grendelmeier
    Citation: Allergy, Asthma & Clinical Immunology 2022 18:44
  31. One of the main barriers to vaccination against SARS-CoV-2 is the fear of developing hypersensitivity reactions to any of its components. Although these reactions are very rare, it is necessary to establish an...

    Authors: Vicente Jover Cerdá, Ramón Rodríguez Pacheco, Joan Doménech Witek, Sonia Alonso Hernández, Rafael Durán García, Marina Real Panisello and Francisco Manuel Marco de la Calle
    Citation: Allergy, Asthma & Clinical Immunology 2022 18:43
  32. Globally, a small proportion (5–12%) of asthma patients are estimated to have severe disease. However, severe asthma accounts for disproportionately high healthcare resource utilization. The Global Initiative ...

    Authors: William J. Calhoun and Geoffrey L. Chupp
    Citation: Allergy, Asthma & Clinical Immunology 2022 18:42
  33. The present narrative review provides a comprehensive update of the current knowledge on urticaria, both in adult and pediatric populations, and on the safety and efficacy of fexofenadine hydrochloride (HCl) a...

    Authors: Ignacio J. Ansotegui, Jonathan A. Bernstein, Giorgio W. Canonica, Sandra N. Gonzalez-Diaz, Bryan L. Martin, Mario Morais-Almeida, Margarita Murrieta-Aguttes and Mario Sanchez Borges
    Citation: Allergy, Asthma & Clinical Immunology 2022 18:41

    The Correction to this article has been published in Allergy, Asthma & Clinical Immunology 2022 18:65

  34. More and more studies had suggested that dyslipidemia was closely related to allergic diseases. High density lipoprotein (HDL) often plays anti-inflammatory and anti-oxidative roles by suppressing immune cell ...

    Authors: Shengli Gao, Qingxiang Zeng, Yinhui Zeng, Yiquan Tang and Wenlong Liu
    Citation: Allergy, Asthma & Clinical Immunology 2022 18:40
  35. Bronchial thermoplasty (BT) is an effective treatment in severe asthma. How to select patients who more likely benefit from BT is an unmet clinical need. Moreover, mechanisms of BT efficacy are still largely u...

    Authors: Nicola Facciolongo, Martina Bonacini, Carla Galeone, Patrizia Ruggiero, Francesco Menzella, Giulia Ghidoni, Roberto Piro, Chiara Scelfo, Chiara Catellani, Alessandro Zerbini and Stefania Croci
    Citation: Allergy, Asthma & Clinical Immunology 2022 18:39
  36. Patients with primary immunodeficiency (PID) are at increased risk for infections such as SARS-CoV-2 (COVID-19), due to the nature of their diseases and being immunocompromised. At this time, four vaccines aga...

    Authors: Babak Aberumand, Whitney Ayoub Goulstone and Stephen Betschel
    Citation: Allergy, Asthma & Clinical Immunology 2022 18:38
  37. Shared learnings from the early use of novel therapies can aid in their optimization. The recent introduction of peanut oral immunotherapy (peanut OIT; Palforzia [Peanut (Arachis hypogaea) Allergen Powder-dnfp]) ...

    Authors: Jay Portnoy, Christina E. Ciaccio, Janet Beausoleil, George Du Toit, Stanley Fineman, Stephen A. Tilles, June Zhang, Claire Lawrence, Mohamed Yassine and S Shahzad Mustafa
    Citation: Allergy, Asthma & Clinical Immunology 2022 18:37
  38. Infants at high risk for developing a food allergy have either an atopic condition (such as eczema) themselves or an immediate family member with such a condition. Breastfeeding should be promoted and supporte...

    Authors: Elissa M. Abrams, Wade Watson, Timothy K. Vander Leek, Adelle Atkinson, Marie-Noel Primeau, Marie-Josee Francoeur, Mary McHenry, Elana Lavine, Julia Orkin, Carl  Cummings, Becky Blair and Edmond S. Chan
    Citation: Allergy, Asthma & Clinical Immunology 2022 18:36
  39. Biologics dramatically improve symptoms of severe asthma; however, various exacerbating factors may induce flare-up. Pneumocystis spp. have not been reported as a cause of asthma exacerbation during biologic use,...

    Authors: Kazuya Takeda, Toshiyuki Sumi, Yuta Nagahisa, Keigo Matsuura, Motoki Sekikawa, Hiroki Watanabe, Yuichi Yamada and Hirofumi Chiba
    Citation: Allergy, Asthma & Clinical Immunology 2022 18:35
  40. The determinants of tolerance to food allergens are not fully understood. We aimed to elucidate the longitudinal association between oropharyngeal symptoms without systemic reactions (OSw/oS) and tolerance to ...

    Authors: Masaaki Hamada, Keigo Saeki and Yoshihiko Sakurai
    Citation: Allergy, Asthma & Clinical Immunology 2022 18:34
  41. The prevalence of allergic diseases is increasing in Zimbabwe and the data relate to local as well as exotic allergen sources. As entomophagy, the practice of eating insects, is a recognised source of local al...

    Authors: Vuyelwa Ndlovu, Moses Chimbari, Pisirai Ndarukwa and Elopy Sibanda
    Citation: Allergy, Asthma & Clinical Immunology 2022 18:33
  42. Safety and effectiveness concerns may preclude physicians from recommending vaccination in mild/moderate inborn errors of immunity (IEI). This study describes attitudes and practices regarding vaccination amon...

    Authors: Sneha Suresh, Joseline Zafack, Anne Pham-Huy, Beata Derfalvi, Manish Sadarangani, Athena McConnell, Bruce Tapiéro, Scott A. Halperin, Gaston De Serres, Jeffrey M Pernica and Karina A. Top
    Citation: Allergy, Asthma & Clinical Immunology 2022 18:32
  43. Common variable immunodeficiency (CVID) is a primary immunodeficiency disorder associated with a broad symptom presentation that is still being characterized. We report a rare case of recurrent mycoplasma skin...

    Authors: David X. Gao, Habiba Hussain, Brianna Bobber and Peter Phan
    Citation: Allergy, Asthma & Clinical Immunology 2022 18:31
  44. Erythritol is widely used as an additive in foods and pharmaceuticals. We present the case of a 6-year-old boy who developed an allergy to erythritol. He showed a positive skin prick test result and a negative...

    Authors: Satomi Mori, Kazuyuki Kurihara and Chisato Inuo
    Citation: Allergy, Asthma & Clinical Immunology 2022 18:28
  45. Penicillin allergy labels frequently impede guideline-directed treatment with a penicillin or other β-lactam antibiotics. Despite presumed allergy, targeted questioning may indicate a low probability of sensit...

    Authors: Philipp Schrüfer, Johanna Stoevesandt and Axel Trautmann
    Citation: Allergy, Asthma & Clinical Immunology 2022 18:26
  46. Hypereosinophilic syndrome (HES) is an extremely uncommon group of disorders. It rarely presents with coagulopathy without cardiac involvement.

    Authors: Kestutis Aukstuolis, Jocelyn J. Cooper, Katherine Altman, Anna Lang and Andrew G. Ayars
    Citation: Allergy, Asthma & Clinical Immunology 2022 18:25

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