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  1. Biologics dramatically improve symptoms of severe asthma; however, various exacerbating factors may induce flare-up. Pneumocystis spp. have not been reported as a cause of asthma exacerbation during biologic use,...

    Authors: Kazuya Takeda, Toshiyuki Sumi, Yuta Nagahisa, Keigo Matsuura, Motoki Sekikawa, Hiroki Watanabe, Yuichi Yamada and Hirofumi Chiba
    Citation: Allergy, Asthma & Clinical Immunology 2022 18:35
  2. The determinants of tolerance to food allergens are not fully understood. We aimed to elucidate the longitudinal association between oropharyngeal symptoms without systemic reactions (OSw/oS) and tolerance to ...

    Authors: Masaaki Hamada, Keigo Saeki and Yoshihiko Sakurai
    Citation: Allergy, Asthma & Clinical Immunology 2022 18:34
  3. The prevalence of allergic diseases is increasing in Zimbabwe and the data relate to local as well as exotic allergen sources. As entomophagy, the practice of eating insects, is a recognised source of local al...

    Authors: Vuyelwa Ndlovu, Moses Chimbari, Pisirai Ndarukwa and Elopy Sibanda
    Citation: Allergy, Asthma & Clinical Immunology 2022 18:33
  4. Safety and effectiveness concerns may preclude physicians from recommending vaccination in mild/moderate inborn errors of immunity (IEI). This study describes attitudes and practices regarding vaccination amon...

    Authors: Sneha Suresh, Joseline Zafack, Anne Pham-Huy, Beata Derfalvi, Manish Sadarangani, Athena McConnell, Bruce Tapiéro, Scott A. Halperin, Gaston De Serres, Jeffrey M Pernica and Karina A. Top
    Citation: Allergy, Asthma & Clinical Immunology 2022 18:32
  5. Common variable immunodeficiency (CVID) is a primary immunodeficiency disorder associated with a broad symptom presentation that is still being characterized. We report a rare case of recurrent mycoplasma skin...

    Authors: David X. Gao, Habiba Hussain, Brianna Bobber and Peter Phan
    Citation: Allergy, Asthma & Clinical Immunology 2022 18:31
  6. Erythritol is widely used as an additive in foods and pharmaceuticals. We present the case of a 6-year-old boy who developed an allergy to erythritol. He showed a positive skin prick test result and a negative...

    Authors: Satomi Mori, Kazuyuki Kurihara and Chisato Inuo
    Citation: Allergy, Asthma & Clinical Immunology 2022 18:28
  7. Penicillin allergy labels frequently impede guideline-directed treatment with a penicillin or other β-lactam antibiotics. Despite presumed allergy, targeted questioning may indicate a low probability of sensit...

    Authors: Philipp Schrüfer, Johanna Stoevesandt and Axel Trautmann
    Citation: Allergy, Asthma & Clinical Immunology 2022 18:26
  8. Hypereosinophilic syndrome (HES) is an extremely uncommon group of disorders. It rarely presents with coagulopathy without cardiac involvement.

    Authors: Kestutis Aukstuolis, Jocelyn J. Cooper, Katherine Altman, Anna Lang and Andrew G. Ayars
    Citation: Allergy, Asthma & Clinical Immunology 2022 18:25
  9. Allergic rhinitis is a risk factor for asthma development. In asthma, fibroblast progenitors, fibrocytes, are increased in the blood and bronchial mucosa following allergen exposure. These cells may play a rol...

    Authors: Marie-Ève Côté, Marie-Ève Boulay, Sophie Plante, Andréanne Côté, Jamila Chakir and Louis-Philippe Boulet
    Citation: Allergy, Asthma & Clinical Immunology 2022 18:24
  10. Intravenous immunoglobulin (IVIG) is increasingly used as a treatment for recurrent pregnancy loss (RPL) despite lack of clear evidence on efficacy. Recent data suggest IVIG might be more effective in a subgro...

    Authors: Denise H. J. Habets, Kim Pelzner, Lotte Wieten, Marc E. A. Spaanderman, Eduardo Villamor and Salwan Al-Nasiry
    Citation: Allergy, Asthma & Clinical Immunology 2022 18:23
  11. Immediate hypersensitivity reactions to COVID-19 vaccines have been postulated to be linked to their excipients, such as polyethylene glycol (PEG) in Pfizer Comirnaty, or polysorbate 80 and ethylenediaminetetr...

    Authors: Syed B. Ali, Griffith Perkins, Dongjae Ryoo, Maverick Lee, Matthew Tunbridge, Chino Yuson, William Smith, Pravin Hissaria and Thanh-Thao Le
    Citation: Allergy, Asthma & Clinical Immunology 2022 18:22
  12. Non-infectious complications have become a major cause of morbidity and mortality in patients with Common Variable Immunodeficiency (CVID). The monitoring of patients with CVID prior to the development of non-...

    Authors: Erika Yue Lee, Stephen Betschel and Eyal Grunebaum
    Citation: Allergy, Asthma & Clinical Immunology 2022 18:21
  13. Allergic rhinitis (AR) is an upper respiratory tract inflammation disease caused by IgE-mediated reactions against inhaled allergens. The incidence of AR is significantly increasing throughout the world. Hence...

    Authors: Yun Hao, Boqian Wang, Jinming Zhao, Ping Wang, Yali Zhao, Xiangdong Wang, Yan Zhao and Luo Zhang
    Citation: Allergy, Asthma & Clinical Immunology 2022 18:20
  14. Primary immunodeficiencies (PI), which include more than 450 single-gene inborn errors of immunity and may affect up to 1% of the population, are genetic disorders that impair the immune system. If not properly i...

    Authors: Jessica Quinn, Vicki Modell, Jordan S. Orange and Fred Modell
    Citation: Allergy, Asthma & Clinical Immunology 2022 18:19
  15. Eosinophilic granulomatosis with polyangiitis (EGPA) is characterized by a necrotizing vasculitis with tissue and peripheral blood eosinophilia affecting small and medium-sized arteries, capillaries, and veins...

    Authors: Sei Adachi, Chiyako Oshikata, Takeshi Kaneko and Naomi Tsurikisawa
    Citation: Allergy, Asthma & Clinical Immunology 2022 18:18
  16. Prolidase deficiency (PD) is an autosomal recessive inborn multisystemic disease caused by mutations in the PEPD gene encoding the enzyme prolidase D, leading to defects in turnover of proline-containing proteins...

    Authors: Nora Alrumayyan, Drew Slauenwhite, Sarah M. McAlpine, Sarah Roberts, Thomas B. Issekutz, Adam M. Huber, Zaiping Liu and Beata Derfalvi
    Citation: Allergy, Asthma & Clinical Immunology 2022 18:17
  17. In the era of COVID-19, utilization of telemedicine has dramatically increased. In addition to reduced travel times, patient expenses, and work or school days missed, telemedicine allows clinicians to provide ...

    Authors: Sarah Edgerley, Rongbo Zhu, Ariba Quidwai, Harold Kim and Samira Jeimy
    Citation: Allergy, Asthma & Clinical Immunology 2022 18:16
  18. Activated phosphoinositide 3-kinase (PI3K) δ syndrome (APDS) is a rare form of primary immunodeficiency with 243 known cases reported in the literature. Known findings associated with the condition include rec...

    Authors: Megan Craig, Bob Geng, Kristen Wigby, Susan A. Phillips, Christine Bakhoum, John Naheedy and Mateja Cernelc-Kohan
    Citation: Allergy, Asthma & Clinical Immunology 2022 18:15
  19. Eosinophilic granulomatosis with polyangiitis (EGPA) is a vasculitis characterized by abnormally high eosinophils and frequent peripheral neuropathy. Mepolizumab is an approved therapy for EGPA, but its effica...

    Authors: Yoshiro Kai, Masanori Yoshikawa, Masayuki Matsuda, Kentaro Suzuki, Hiroya Ohara, Naohiko Iguchi, Takehito Kasamatsu, Kenji Uno, Nobuhiro Fujioka, Yukio Fujita and Shigeo Muro
    Citation: Allergy, Asthma & Clinical Immunology 2022 18:14
  20. Eosinophilic granulomatosis with polyangiitis (EGPA) is a rare vasculitis. Although glucocorticoid therapy with or without immunosuppressants leads to remission in the majority of cases, most EGPA patients rem...

    Authors: Danxu Ma, Yuting Xue, Rong Shi, Yinan Yang, Huili Li, Xuhua Shi, Li Wang and Yun Wang
    Citation: Allergy, Asthma & Clinical Immunology 2022 18:13
  21. Epidemiological studies have revealed a link between atopic dermatitis (AD) and asthma. AS1517499, a selective signal transducer and activation of transcription 6 (STAT6) inhibitor, has been shown to effective...

    Authors: Xueying Li, Zhaoqing Han, Feng Wang and Jianou Qiao
    Citation: Allergy, Asthma & Clinical Immunology 2022 18:12
  22. Allergic rhinitis (AR) and allergic contact dermatitis (ACD) are prevalent allergic diseases and have significant impacts on patients’ daily life. Despite many studies on AR or ACD have been conducted separate...

    Authors: Wenjia Chai, Xuyi Zhang, Meixiong Lin, Zhuo Chen, Xiaolin Wang, Changqing Wang, Aoyan Chen, Caisheng Wang, Hongwu Wang, Honghong Yue and Jingang Gui
    Citation: Allergy, Asthma & Clinical Immunology 2022 18:10
  23. Atopic dermatitis is a common chronic skin disease that can occur in pregnancy. Current treatments include topical and systemic glucocorticoids and cyclosporine. Presently, the only biologic approved for atopi...

    Authors: Nabeel H. Akhtar, Touraj Khosravi-Hafshejani, Daud Akhtar, Gurbir Dhadwal and Amin Kanani
    Citation: Allergy, Asthma & Clinical Immunology 2022 18:9
  24. Food Protein-Induced Enterocolitis Syndrome (FPIES) is a non-IgE mediated food allergy most commonly presenting in infants. The most common food triggers include soy, cow’s milk and grains. Symptoms may includ...

    Authors: Jessica Sultafa, Lundy McKibbon, Hannah Roberts, Jumana Sarraj and Harold Kim
    Citation: Allergy, Asthma & Clinical Immunology 2022 18:8
  25. There is currently little Canadian data to assess how well traditional time-based residency training programs have prepared residents for careers in Clinical Immunology and Allergy (CIA). This study aims to id...

    Authors: Chloe Cyr, Michael Cyr, Jaclyn Quirt and Lori Connors
    Citation: Allergy, Asthma & Clinical Immunology 2022 18:7
  26. Staphylococcus aureus (SA) nasal carriage (SA carriage) and IgE-sensitization to SA enterotoxin (SE IgE-sensitization) are known to be associated with chronic airway disease.

    Authors: Han-Ki Park, Seok-Ju Yoo, Taek Soo Kim, Byung-Keun Kim, Sekyung Jang, Sung Yeon Kim and Kwan Lee
    Citation: Allergy, Asthma & Clinical Immunology 2022 18:6
  27. Multiple sclerosis (MS) and neuromyelitis optica syndrome disease (NMOSD) are inflammatory diseases of the central nervous system. The pathogenesis and treatments for these two conditions are very different. N...

    Authors: Leila Khani, Mir Hadi Jazayeri, Reza Nedaeinia, Mahmood Bozorgmehr, Seyed Masood Nabavi and Gordon A. Ferns
    Citation: Allergy, Asthma & Clinical Immunology 2022 18:5
  28. Hereditary angioedema (HAE) is characterized by potentially severe and life-threatening attacks of localized swelling. Prophylactic therapies are available, including attenuated androgens. Efficacy of attenuat...

    Authors: Marcus Maurer, Markus Magerl, Emel Aygören-Pürsün, Konrad Bork, Henriette Farkas, Hilary Longhurst, Sorena Kiani‑Alikhan, Laurence Bouillet, Isabelle Boccon-Gibod, Mauro Cancian, Andrea Zanichelli and David Launay
    Citation: Allergy, Asthma & Clinical Immunology 2022 18:4
  29. Airway obstruction (AO) in asthma is driven by airway smooth muscle (ASM) contraction. AO can be induced extrinsically by direct stimulation of ASM with contractile agonists as histamine, or by indirect provoc...

    Authors: Mayra D. Álvarez-Santos, Marisol Álvarez-González, Elizabeth Eslava-De-Jesus, Angel González-López, Ivonne Pacheco-Alba, Yazmín Pérez-Del-Valle, Rodrigo Rojas-Madrid and Blanca Bazán-Perkins
    Citation: Allergy, Asthma & Clinical Immunology 2022 18:3
  30. Nodular regenerating hyperplasia (NRH) is the most common liver involvement in common variable immunodeficiency (CVID). Most patients are asymptomatic with gradually increasing alkaline phosphatase (ALP) and mild...

    Authors: Mongkhon Sompornrattanaphan, Ranista Tongdee, Chamard Wongsa, Anupop Jitmuang and Torpong Thongngarm
    Citation: Allergy, Asthma & Clinical Immunology 2022 18:2
  31. The Icatibant Outcome Survey (IOS) is an international registry monitoring the use of icatibant, a bradykinin B2 receptor antagonist indicated for the acute treatment of hereditary angioedema (HAE) attacks. Our g...

    Authors: Mar Guilarte, Anna Sala-Cunill, María Luisa Baeza, Rosario Cabañas, María Dolores Hernández, Ethel Ibañez, Carlos Hernando de Larramendi, Ramon Lleonart, Teófilo Lobera, Luis Marqués, Blanca Sáenz de San Pedro, Jaco Botha, Irmgard Andresen and Teresa Caballero
    Citation: Allergy, Asthma & Clinical Immunology 2021 17:137
  32. True allergy to metronidazole, a common anti-infective in clinical practice, is rarely reported in the literature. In the case of Trichomonas, there are few alternatives to the nitrimidazole class of drugs, and t...

    Authors: Julia A. Cahill, Preena Simritpreet Sahota and Manstein Kan
    Citation: Allergy, Asthma & Clinical Immunology 2021 17:136
  33. The relationship between allergies and sinusitis, though extensively studied, remains poorly defined. While several studies proposed a cause-and-effect relationship between allergy and chronic sinusitis, sever...

    Authors: Song Li, Chu-Jin Zhao, Hong-Li Hua, Yu-Qin Deng and Ze-Zhang Tao
    Citation: Allergy, Asthma & Clinical Immunology 2021 17:135
  34. There exists a geographic barrier to access CIA care for patients who live in rural communities; telemedicine may bridge this gap in care. Herein we characterized the use of telemedicine in CIA at a population...

    Authors: Erika Yue Lee, Christine Song, Peter Vadas, Matthew Morgan and Stephen Betschel
    Citation: Allergy, Asthma & Clinical Immunology 2021 17:131
  35. Epinephrine is the first line treatment for anaphylaxis, an acute potentially life-threatening allergic reaction. It is typically administered intramuscularly in the anterolateral thigh at a dose of 0.01 mg/kg...

    Authors: Lucy Dong Xuan Li, Elissa M. Abrams, Elana Lavine, Kyla Hildebrand and Douglas Paul Mack
    Citation: Allergy, Asthma & Clinical Immunology 2021 17:130
  36. The Global Initiative for Asthma has only recently added tiotropium bromide as adjunct controller therapy in severe asthma (Step 4 or 5) in adults (2015) and children (2019). Although not yet approved for pedi...

    Authors: Zainab Ridha, Marc-Antoine Bédard, Anna Smyrnova, Olivier Drouin, Aniela Pruteanu, Sandrine Essouri and Francine M. Ducharme
    Citation: Allergy, Asthma & Clinical Immunology 2021 17:129
  37. Refractory status asthmaticus is the cause of rare cases of in-hospital death due to acute bronchial asthma. The most severe cases unresponsive to first, second and next line treatment may be fatal despite agg...

    Authors: Jan Benes, Roman Skulec, Dalibor Jilek, Ondrej Fibigr and Vladimir Cerny
    Citation: Allergy, Asthma & Clinical Immunology 2021 17:128
  38. Post hoc analyses of randomized placebo-controlled trials have demonstrated efficacy and tolerability of the ragweed sublingual immunotherapy (SLIT)-tablet in Canadian adults with ragweed pollen-induced allerg...

    Authors: Anne K. Ellis, Remi Gagnon, David I. Bernstein and Hendrik Nolte
    Citation: Allergy, Asthma & Clinical Immunology 2021 17:127
  39. Dedicator of cytokinesis 2 (DOCK2) deficiency is an inborn error of immunity characterized by cellular and humoral immunological abnormalities leading to early-onset infections.

    Authors: Niusha Sharifinejad, Homa Sadri, Arash Kalantari, Samaneh Delavari, Amirhosein Noohi, Yasaman Aminpour, Araz Sabzevari and Gholamreza Azizi
    Citation: Allergy, Asthma & Clinical Immunology 2021 17:126
  40. Sublingual immunotherapy tablets (SLIT-T) are an effective treatment for allergic rhinitis (AR), but some patients experience local allergic reactions (LAR) in the first few weeks of treatment that can lead to...

    Authors: Anne K. Ellis, Lori Connors, Marie-Josee Francoeur and Douglas P. Mack
    Citation: Allergy, Asthma & Clinical Immunology 2021 17:125
  41. Granulomatosis with polyangiitis (GPA) is a syndrome of refractory vasculitis involving the upper respiratory tract, lungs, kidneys, and systemic small and medium-sized arteries that affects all age groups. No...

    Authors: Memi Kato, Keisuke Jimbo, Masumi Nagata, Yoshiko Endo, Kosuke Kashiwagi, Kimiko Maruyama, Natsuki Ito, Kaori Tokushima, Nobuyasu Arai, Reiko Kyodo, Masamichi Sato, Eri Miyata, Kenji Hosoi, Eisuke Inage, Tamaki Ikuse, Hideo Fukunaga…
    Citation: Allergy, Asthma & Clinical Immunology 2021 17:124

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