Articles

Progress and Challenges in the Understanding of Chronic Urticaria

Chronic urticaria is a skin disorder characterized by transient pruritic weals that recur from day to day for 6 weeks or more. It has a great impact on patients' quality of life. In spite of this prevalence an...

Authors: Marta Ferrer and Allen P Kaplan

Up-Regulation of Interleukin-9 and the Interleukin-9-Associated Calcium-Activated Chloride Channel hCLCA1 in Nasal Mucosa Following In Vivo Allergen Challenge

Interleukin (IL)-9 is a pleiotropic T helper 2-type cytokine that has been shown to be up-regulated in allergic airway disease, including asthma. IL-9 has been demonstrated to be a potent stimulus for the prod...

Authors: Hans-Peter Hauber, Celine Bergeron, Masao Toda, Mario Kontolemos, Kenneth J. Holroyd, Roy C. Levitt and Qutayba Hamid

Maternal Smoking in Pregnancy: Do the Effects on Innate (Toll-Like Receptor) Function Have Implications for Subsequent Allergic Disease?

Subtle increases in immaturity of immune function in early infancy have been implicated in the rising susceptibility to allergic disease, particularly relative impairment of type 1 interferon (IFN)-γ responses...

Authors: Susan L. Prescott and Paul S. Noakes

Meeting program

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Local Nasal Specific Immunotherapy for Allergic Rhinitis

The possibility of producing local hyposensitization by administering allergens via mucosal routes was envisaged at the beginning of 1900, and local nasal immunotherapy has been extensively studied since the 1...

Authors: Giovanni Passalacqua and Giorgio Walter Canonica

The Difficult-to-Control Asthmatic: A Systematic Approach

With the judicious use of inhaled corticosteroids, β₂ agonists, and leukotriene modifiers, most patients with asthma are easily controlled and managed. However, approximately 5% of asthmatics do not respond to st...

Authors: Annie V Le and Ronald A Simon

Mechanisms of Degranulation in Neutrophils

Neutrophils are critical inflammatory cells that cause tissue damage in a range of diseases and disorders. Being bone marrow-derived white blood cells, they migrate from the bloodstream to sites of tissue infl...

Authors: Paige Lacy

Coaggregation of FcεRI with FcγRIIB Inhibits Degranulation but Not Induction of Bcl-2 Family Members A1 and Bim in Mast Cells

The aggregation of high-affinity immunoglobulin E (IgE) receptors (FcεRI) on mast cells is a critical event in the initiation of an allergic reaction. Coengagement of FcεRI with immunoglobulin G (IgG) low-affi...

Authors: Maria Ekoff, Christine Möller, Zou Xiang and Gunnar Nilsson

Nonimmunoglobulin E-Mediated Immune Reactions to Foods

Adverse food reactions are abnormal responses to ingested foods. Reactions vary from immunologic to nonimmunologic immune reactions and can be either immunoglobulin E (IgE) mediated or non-IgE mediated. Food-i...

Authors: Jonathan M Spergel

Critical Aspects of the History of Occupational Asthma

The medical history is the gateway to the diagnosis of occupational asthma. The medical history should indicate whether a patient's asthma began during a work period and whether the asthma worsens during work ...

Authors: Susan M. Tarlo

Potential Adverse and Allergic Reactions from Complementary and Alternative Medicine and Dietary Supplements

Complementary and alternative medicine and dietary supplements are often used by patients. A detailed examination of each preparation used by four patients was carried out. Seven such preparations with the pot...

Authors: H.C. George Wong

Lack of Correlation between Severity of Clinical Symptoms, Skin Test Reactivity, and Radioallergosorbent Test Results in Venom-Allergic Patients

To retrospectively examine the relation between skin test reactivity, venom-specific immunoglobulin E (IgE) antibody levels, and severity of clinical reaction in patients with insect venom allergy.

Authors: R.J. Warrington

Consensus Guidelines on Practical Issues of Immunotherapy-Canadian Society of Allergy and Clinical Immunology (CSACI)

Authors: Eric Leith, Tom Bowen, Joe Butchey, David Fischer, Harold Kim, Bill Moote, Peter Small, Don Stark and Susan Waserman

2003 Canadian Asthma Consensus Guidelines Executive Summary

Guidelines for the diagnosis and management of asthma have been published over the last 15 years; however, there has been little focus on issues relating to asthma in childhood. Since the last revision of the ...

Authors: Allan Becker, Catherine Lemière, Denis Bérubé, Louis-Philippe Boulet, Francine Ducharme, Mark FitzGerald and Thomas Kovesi

Erythropoietic Protoporphyria Masquerading as Angioedema in a 4-Year-Old Female

Angioedema is a common presentation with a broad differential, including rare disorders with which an allergist must be familiar. Our objective was to report a case of swelling of the hands and feet mimicking ...

Authors: Helen C Wang and Ejaz Yousef

Skin Test Reactivity to Indoor Allergens Correlates with Asthma Severity in Jeddah, Saudi Arabia

There is increased emphasis on the role of indoor allergens in asthma.

Authors: Emad A Koshak

Prevalence and Severity of Asthma, Rhinitis, and Atopic Eczema in 13- to 14-Year-Old Schoolchildren from Southern Brazil

The objective of this study was to investigate the prevalence and severity of asthma, rhinitis, and atopic eczema in schoolchildren from southern Brazil. A cross-sectional study was carried out with the Intern...

Authors: Arnaldo C Porto Neto, Rafael D'Agostini Annes, Nathalia MM Wolff, Andréia P Klein, Francisco C dos Santos, Juliana L Dullius, Marina Gressler, Letícia S Muller, Cristine F Angonese and Sérgio Menna-Barreto

Letter to the Editor

Authors: Emil Nashi, Devi Banerjee, Thomas Hudson and Rhoda Kagan

Update on Allergy Immunotherapy

This article summarizes and provides commentary regarding guidelines on the administration of immunotherapy (IT) for allergic airway disease. Recent investigations have provided important insights into the imm...

Authors: William Davidson, Sean Lucas and Larry Borish

Pediatric Hemophagocytic Syndromes: A Diagnostic and Therapeutic Challenge

Pediatric hemophagocytic syndrome (HS) is a severe and often fatal clinical disorder. This syndrome is frequently unrecognized, and thus, affected children may receive suboptimal management, leading to an incr...

Authors: Nada Jabado, Christine McCusker and Genevieve de Saint Basile

Association of the Frequency of Respiratory Illness in Early Childhood with a Change in the Distribution of Blood Lymphocyte Subpopulations

Little is known about the distribution of lymphocyte phenotypes in young children and the association specific phenotypes may have with respiratory illnesses. The objective of this study was to describe lympho...

Authors: Jacob Karsh, Jonathan B Angel, Charlene D Young, Vanita Sahni, Stan Judek, David Miller and Robert E Dales

Subcutaneous Immunoglobulin-G Replacement Therapy with Preparations Currently Available in the United States for Intravenous or Intramuscular Use: Reasons and Regimens

For patients who require replacement therapy for primary immunodeficiency, subcutaneous infusions of immunoglobulin G (IgG) may be preferable to intravenous infusions for several reasons. However, at present, ...

Authors: Akhilesh Chouksey, Kimberly Duff, Nancy Wasserbauer and Melvin Berger

GOAL: What Have We Learned?

Authors: Timothy K Vander Leek

Annual Scientific Meeting, Winnipeg, September 22-25, 2005

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Relationship between Asthma and Rhinitis: Epidemiologic, Pathophysiologic, and Therapeutic Aspects

Over the last few years, the evidence of links between rhinitis and asthma has been strengthened. This has led to the introduction of the concept of united airway disease. Rhinitis and asthma appear to be inte...

Authors: Celine Bergeron and Qutayba Hamid

Significance of Conversation between Mast Cells and Nerves

More and more studies are demonstrating interactions between the nervous system and the immune system. However, the functional relevance of this interaction still remains to be elucidated. Such associations ha...

Authors: Hanneke PM van der Kleij and John Bienenstock

Role of Leukotriene Receptor Antagonists in the Treatment of Exercise-Induced Bronchoconstriction: A Review

Asthma is a very common disorder that still causes significant morbidity and mortality. A high percentage of individuals with asthma also experience exercise-induced bronchoconstriction (EIB). This article rev...

Authors: George S Philteos, Beth E Davis, Donald W Cockcroft and Darcy D Marciniuk

Fishing for Allergens: Bloodworm-Induced Asthma

Hypersensitivity to bloodworms (chironomid larvae) leading to asthma and other related allergic disorders is becoming common in individuals who keep or work with fish due to the increased use of bloodworms as ...

Authors: Keith CP Wu, Katja Räsänen and Thomas J Hudson

Platelet-Activating Factor Antagonists Decrease Follicular Dendritic-Cell Stimulation of Human B Lymphocytes

Both B-lymphoblastoid cell lines and tonsillar B lymphocytes express receptors for platelet-activating factor (PAF). In lymph node germinal centres, B lymphocytes interact with follicular dendritic cells (FDCs...

Authors: Isaac Halickman, Yolande Bastien, Qianli Zhuang, Monty B Mazer, Baruch Toledano and Bruce D Mazer

Fishy Food for Thought

Authors: R. Robert Schellenberg

Asthma and Therapeutics: Recombinant Therapies in Asthma

Numerous recombinant therapies are being investigated for the treatment of asthma. This report reviews the current status of several of these novel agents. Anti-immunoglobulin (Ig)E (omalizumab, Xolair) marked...

Authors: Donald W Cockcroft

Asthma and Therapeutics: Inhaled Corticosteroids, Corticosteroid Osteoporosis, and the Risk of Fracture in Chronic Asthma

Current guidelines for the diagnosis and treatment of osteoporosis do not address the risks to bone density and the likelihood of fracture that may be associated with inhaled corticosteroid treatment for asthm...

Authors: John H Toogood

Advances in the Surgical Management of Chronic Rhinosinusitis

The surgical management of chronic rhinosinusitis has evolved considerably in the last decade. We currently have a more refined understanding of the various disease entities that make up the generic diagnosis ...

Authors: Erin D Wright and Saul Frenkiel

Canadian Allergy, Asthma and Immunology Foundation

Authors: Richard Warrington and Keith Payton

Annual Meeting, Ottawa, October 21-24, 2004

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