Articles

HAE therapies: past present and future

Advances in understanding the pathophysiology and mechanism of swelling in hereditary angioedema (HAE) has resulted in the development of multiple new drugs for the acute and prophylactic treatment of patients...

Authors: Bruce L Zuraw

The clinical utility of molecular diagnostic testing for primary immune deficiency disorders: a case based review

Primary immune deficiency disorders (PIDs) are a group of diseases associated with a genetic predisposition to recurrent infections, malignancy, autoimmunity and allergy. The molecular basis of many of these d...

Authors: Rohan Ameratunga, See-Tarn Woon, Katherine Neas and Donald R Love

Treatment of Hereditary Angioedema: items that need to be addressed in practice parameter

Hereditary Angioedema (HAE) is a rare, autosomal dominant (AD) disorder caused by a C1 esterase inhibitor (C1-inh) deficiency or qualitative defect. Treatment of HAE in many parts of the world fall short and c...

Authors: Callie Dagen and Timothy J Craig

Rhinitis in the geriatric population

The current geriatric population in the United States accounts for approximately 12% of the total population and is projected to reach nearly 20% (71.5 million people) by 2030[1]. With this expansion of the numbe...

Authors: Jayant M Pinto and Seema Jeswani

Clinical experience in T cell deficient patients

T cell disorders have been poorly understood until recently. Lack of knowledge of underlying molecular mechanisms together with incomplete data on long term outcome have made it difficult to assess prognosis a...

Authors: Theresa S Cole and Andrew J Cant

Characteristics of anaphylaxis in a pediatric emergency department (ED): does management follow published guidelines?

Authors: L Elkout and W Watson

A systematic review of the efficacy and safety of a purified, pasteurized C1 inhibitor concentrate for the treatment of patients with type I or II hereditary angioedema

Authors: K Bork, I Steffense, A Neme, A Morrison, G van den Hoef and D Barnes

Treatment of initial allergic reactions to peanut inside and outside of health care facilities

Authors: L Soller, M Ben-Shoshan, J Fragapane, L Joseph, Y St Pierre, L Harada, C Fortin, M Allen and AE Clarke

Managing paediatric eosinophilic gastroenteropathies: a community experience

Authors: J Liem, O Hakim and A Zaher

Onset of action of loratadine/montelukast combination in subjects with seasonal allergic rhinitis in the environmental exposure unit

Authors: JH Day, MP Briscoe, JD Ratz, AK Ellis, M Danzig and R Yao

The controlled allergen challenge experience: comparison of allergic upper respiratory symptoms in the environmental exposure unit (EEU) and during seasonal exposure

Authors: AK Ellis, E Rafeiro, JD Ratz and JH Day

Fast 3: a phase III randomized double-blind, placebo-controlled multicenter study of Icatibant for subcutaneous injection in patients with acute Attacks of Hereditary Angioedema (HAE)

Authors: B Ritchie

Raw wheat allergy: a case report

Authors: L Connors, G Lacuesta, S Kapur and G Rex

Adjunctive treatment of chronic idiopathic urticaria and angioedema with sulfasalazine

Authors: T Pitt, R Warrington and C Kalicinsky

An elusive case of systemic mastocytosis

Authors: JK Lee and P Vadas

A dramatic case of non-episodic angioedema with eosinophilia

Authors: M Clements-Baker and R Borici-Mazi

Rifampin hypersensitivity in a two year-old child with successful rapid oral desensitization

Authors: KJ Hildebrand and D Hummel

Effects of nitric oxide-induced aldolase nitration on the glycolytic metabolites of mast cell

Authors: Y Sekar, T Chul Moon, CM Slupsky and AD Befus

Interleukin-33 in asthma: insights into pro-inflammatory roles of airway structural cells

Authors: D Préfontaine, L Al-Awan, AK Mogas, S Audusseau, S Lajoie-Kadoch, R Olivenstein, J Chakir, AJ Halayko, C Lemière, JG Martin and Q Hamid

Local Toll-like receptor-mediated mast cell activation inhibits melanoma growth

Authors: SA Oldford, ID Haidl, MA Howatt, CA Leiva, B Johnston and JS Marshall

Does IgE-mediated mast cell activation reduce oral tolerance to food antigens?

Authors: M Tunis and JS Marshall

Atopy affects LPS responsiveness and TLR-4 expression in children peripheral mononuclear cells

Authors: D Préfontaine, AA Banville-Langelier, PO Fiset, J Guay, Q Hamid and BD Mazer

Differential effects of C5a on human and mouse mast cells may be mediated by C5aR and C5L2

Authors: P Pundir, CH Sheen, A Catalli, V Karpov, K Cianflone and M Kulka

Human mast cells respond to viral infection by recruiting NK cells and T cells

Authors: SM Burke, M Shmulevitz, K Mohan, PWK Lee, TB Issekutz and JS Marshall

Comparison of the inhibitory effects of resveratrol and tranilast on IgE, 48/80 and substance P dependent-mast cell activation

Authors: A Catalli, V Karpov, P Pundir, A Dimitrijevic and M Kulka

Inhibition of IgE and IgE/anti-IgE mediated responses in mast cells by Omalizumab

Authors: M Kulka and A Catalli

Effectiveness study of an online anaphylaxis training program for school personnel: overview of methods for a pilot study in a large Canadian school board

Authors: AJ Levinson, L Colizza, L Harada, S Waserman and S Garside

Assessing a population-based approach to the management of respiratory disease

Authors: C Hampson, O Latycheva, MM Vine, SJ Elliott and M Haynes

Are teachers knowledgeable and confident about dealing with allergy emergencies?

Authors: W Watson, AM Woodrow, A Bruce and A Power

Assessing a community-based asthma education intervention

Authors: MM Vine, SJ Elliott, M Haynes, O Latycheva and C Hampson

Rhinorrhea, cough and fatigue in patients taking sitagliptin

Sitagliptin is a dipeptidyl peptidase-4 (DPP IV, CD26) inhibitor indicated for treatment of Type II diabetes as a second line therapy after metformin. We report fifteen sitagliptin intolerant patients who deve...

Authors: James N Baraniuk and Mary J Jamieson

Estimation of the environmental attributable fraction of asthma among Canadian children: a systematic review

Authors: E Simons, T To and S Dell

Long-term safety of inhaled corticosteroids in children

Authors: S Pedersen

Asthma control – components and clinical importance

Authors: S Pedersen

The impact of participation in the SAGE study on parent behavior

Authors: R Chooniedass, AL Kozyrskyj and AB Becker

Likelihood of adrenaline auto-injectors being mis-prescribed by primary care physicians

Authors: DA Fischer

Early life nutrition, the developing immune system and subsequent allergic manifestations

Authors: JLP Protudjer, GP Sevenhuysen, CD Ramsey, JM McGavock and AB Becker

Oilseed rape allergy: is it significant? An investigation into its prevalence in an East Anglian population, UK

Authors: A Trinidade, S Kumar, A Farboud, M Shakeel and P Leong

Likelihood of Stachybotyrs atra sensitization in Canadian populations

Authors: DA Fischer, Kim HL Barrie and ON Kitchener

Prenatal allergen and diesel exhaust exposure and their effects on allergy in adult offspring mice

Multiple studies have suggested that prenatal exposure to either allergens or air pollution may increase the risk for the development of allergic immune responses in young offspring. However, the effects of pr...

Authors: Lin Corson, Huaijie Zhu, Chunli Quan, Gabriele Grunig, Manisha Ballaney, Ximei Jin, Frederica P Perera, Phillip H Factor, Lung-Chi Chen and Rachel L Miller

Birth order modifies the effect of IL13 gene polymorphisms on serum IgE at age 10 and skin prick test at ages 4, 10 and 18: a prospective birth cohort study

Susceptibility to atopy originates from effects of the environment on genes. Birth order has been identified as a risk factor for atopy and evidence for some candidate genes has been accumulated; however no st...

Authors: Ikechukwu U Ogbuanu, Wilfried J Karmaus, Hongmei Zhang, Tara Sabo-Attwood, Susan Ewart, Graham Roberts and Syed H Arshad

Kimura's disease with eosinophilic panniculitis - treated with cyclosporine: a case report

Kimura's disease is a rare, benign, slow growing chronic inflammatory swelling with a predilection for the head and neck region and almost always with peripheral blood eosinophilia and elevated serum IgE level...

Authors: Davood Maleki, Alireza Sayyah, Mohammad Hossein Rahimi-Rad and Nasrin Gholami

TSLP directly impairs pulmonary Treg function: association with aberrant tolerogenic immunity in asthmatic airway

Even though thymic stromal lymphopoietin (TSLP) has been implicated in the development of allergic inflammation, its influence on immune tolerance mediated by regulatory T cells (Treg) have not been explored. ...

Authors: Khoa D Nguyen, Christopher Vanichsarn and Kari C Nadeau

Alterations in the complement cascade in post-traumatic stress disorder

In the present study we assessed the functional state of the major mediator of the immune response, the complement system, in post-traumatic stress disorder (PTSD).

Authors: Lilit P Hovhannisyan, Gohar M Mkrtchyan, Samvel H Sukiasian and Anna S Boyajyan

Skin prick testing in patients using beta-blockers: a retrospective analysis

The use of beta-blockers is a relative contraindication in allergen skin testing yet there is a paucity of literature on adverse events in this circumstance. We examined a population of skin tested patients on...

Authors: Irene N Fung and Harold L Kim

Panallergens and their impact on the allergic patient

The panallergen concept encompasses families of related proteins, which are involved in general vital processes and thus, widely distributed throughout nature. Plant panallergens share highly conserved sequenc...

Authors: Michael Hauser, Anargyros Roulias, Fátima Ferreira and Matthias Egger

The anti-inflammatory effects of levocetirizine - are they clinically relevant or just an interesting additional effect?

Levocetirizine, the R-enantiomer of cetirizine dihydrochloride has pharmacodynamically and pharmacokinetically favourable characteristics, including rapid onset of action, high bioavailability, high affinity f...

Authors: Garry M Walsh

Stem cells, inflammation and allergy

Recently, many studies have suggested a potential role for early hematopoietic progenitor cell and hematopoietic stem cell (HSC) recruitment and differentiation in the development of allergy and inflammation. ...

Authors: Marie-Renee Blanchet and Kelly M McNagny

Hodgkin's lymphoma presenting with markedly elevated IgE: a case report

Markedly elevated IgE as a manifestation of a lymphoproliferative disorder has been only rarely reported.

Authors: Anne K Ellis and Susan Waserman

Importance of basophil activation testing in insect venom allergy

Venom immunotherapy (VIT) is the only effective treatment for prevention of serious allergic reactions to bee and wasp stings in sensitized individuals. However, there are still many questions and controversie...

Authors: Mitja Kosnik and Peter Korosec