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  1. Sitagliptin is a dipeptidyl peptidase-4 (DPP IV, CD26) inhibitor indicated for treatment of Type II diabetes as a second line therapy after metformin. We report fifteen sitagliptin intolerant patients who deve...

    Authors: James N Baraniuk and Mary J Jamieson

    Citation: Allergy, Asthma & Clinical Immunology 2010 6:8

    Content type: Research

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  2. Multiple studies have suggested that prenatal exposure to either allergens or air pollution may increase the risk for the development of allergic immune responses in young offspring. However, the effects of pr...

    Authors: Lin Corson, Huaijie Zhu, Chunli Quan, Gabriele Grunig, Manisha Ballaney, Ximei Jin, Frederica P Perera, Phillip H Factor, Lung-Chi Chen and Rachel L Miller

    Citation: Allergy, Asthma & Clinical Immunology 2010 6:7

    Content type: Research

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  3. Susceptibility to atopy originates from effects of the environment on genes. Birth order has been identified as a risk factor for atopy and evidence for some candidate genes has been accumulated; however no st...

    Authors: Ikechukwu U Ogbuanu, Wilfried J Karmaus, Hongmei Zhang, Tara Sabo-Attwood, Susan Ewart, Graham Roberts and Syed H Arshad

    Citation: Allergy, Asthma & Clinical Immunology 2010 6:6

    Content type: Research

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  4. Kimura's disease is a rare, benign, slow growing chronic inflammatory swelling with a predilection for the head and neck region and almost always with peripheral blood eosinophilia and elevated serum IgE level...

    Authors: Davood Maleki, Alireza Sayyah, Mohammad Hossein Rahimi-Rad and Nasrin Gholami

    Citation: Allergy, Asthma & Clinical Immunology 2010 6:5

    Content type: Case report

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  5. Even though thymic stromal lymphopoietin (TSLP) has been implicated in the development of allergic inflammation, its influence on immune tolerance mediated by regulatory T cells (Treg) have not been explored. ...

    Authors: Khoa D Nguyen, Christopher Vanichsarn and Kari C Nadeau

    Citation: Allergy, Asthma & Clinical Immunology 2010 6:4

    Content type: Research

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  6. The panallergen concept encompasses families of related proteins, which are involved in general vital processes and thus, widely distributed throughout nature. Plant panallergens share highly conserved sequenc...

    Authors: Michael Hauser, Anargyros Roulias, Fátima Ferreira and Matthias Egger

    Citation: Allergy, Asthma & Clinical Immunology 2010 6:1

    Content type: Review

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  7. Recently, many studies have suggested a potential role for early hematopoietic progenitor cell and hematopoietic stem cell (HSC) recruitment and differentiation in the development of allergy and inflammation. ...

    Authors: Marie-Renee Blanchet and Kelly M McNagny

    Citation: Allergy, Asthma & Clinical Immunology 2009 5:13

    Content type: Review

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  8. Urticaria is a group of diseases that share a distinct skin reaction pattern. Triggering of urticaria by infections has been discussed for many years but the exact role and pathogenesis of mast cell activation...

    Authors: Bettina Wedi, Ulrike Raap, Dorothea Wieczorek and Alexander Kapp

    Citation: Allergy, Asthma & Clinical Immunology 2009 5:10

    Content type: Review

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  9. Exercise-induced bronchoconstriction (EIB) is described by transient narrowing of the airways after exercise. It occurs in approximately 10% of the general population, while athletes may show a higher prevalen...

    Authors: Pnina Weiss and Kenneth W Rundell

    Citation: Allergy, Asthma & Clinical Immunology 2009 5:7

    Content type: Review

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  10. A reliable screening test in newborns for the subsequent development of bronchial asthma (BA) has not been found yet. This is mainly due to the complexity of BA, being made up by different types and underlying...

    Authors: Hugo PS Van Bever

    Citation: Allergy, Asthma & Clinical Immunology 2009 5:6

    Content type: Review

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  11. Allergic disorders are very common in the pediatric age group. While the exact etiology is unclear, evidence is mounting to incriminate environmental factors and an aberrant gut microbiota with a shift of the ...

    Authors: Sonia Michail

    Citation: Allergy, Asthma & Clinical Immunology 2009 5:5

    Content type: Review

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  12. Pollen allergy is characterized by a TH2-biased immune response to pollen-derived allergens. However, pollen-exposed epithelia do not encounter pure allergen but rather a plethora of protein and non-protein subst...

    Authors: Stefanie Gilles, Valentina Mariani, Martina Bryce, Martin J Mueller, Johannes Ring, Heidrun Behrendt, Thilo Jakob and Claudia Traidl-Hoffmann

    Citation: Allergy, Asthma & Clinical Immunology 2009 5:3

    Content type: Review

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  13. Food allergy is a serious and potentially life-threatening problem for an estimated 6% of children and 3.7% of adults. This review examines the diagnostic process that begins with a patient's history and physi...

    Authors: John Eckman, Sarbjit S Saini and Robert G Hamilton

    Citation: Allergy, Asthma & Clinical Immunology 2009 5:2

    Content type: Review

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  14. It is our pleasure to welcome you to the new website of Allergy, Asthma & Clinical Immunology (AACI).

    Authors: Richard Warrington

    Citation: Allergy, Asthma & Clinical Immunology 2009 5:1

    Content type: Editorial

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  15. Work-related asthma is asthma that is caused or exacerbated by exposures at work. It is the most common form of occupational lung disease in developed countries. It has important impacts on the health and well...

    Authors: Tracy Stoughton, Michael Prematta and Timothy Craig

    Citation: Allergy, Asthma & Clinical Immunology 2008 4:164

    Content type: Research

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  16. The immunosuppressive activity of estrogen was further investigated by assessing the pattern of expression of CD25, CD28, CD69, and CD152 on vaginal T cells during estrogen-maintained vaginal candidiasis. A pr...

    Authors: Ameera Al-Sadeq, Mawieh Hamad and Khaled Abu-Elteen

    Citation: Allergy, Asthma & Clinical Immunology 2008 4:157

    Content type: Research

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  17. The objective of this study was to determine the risk of peanut allergy in siblings of peanut-allergic children. In 2005-2006, 560 households of children born in 1995 in the province of Manitoba, Canada, were ...

    Authors: Joel J. Liem, Saiful Huq, Anita L. Kozyrskyj and Allan B. Becker

    Citation: Allergy, Asthma & Clinical Immunology 2008 4:144

    Content type: Research

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  18. Peanut allergies have been increasing in prevalence in most industrialized countries. Onset is typically in early childhood, with a trend towards earlier ages of presentation. The allergy is lifelong in most a...

    Authors: Nasser Al-Ahmed, Shirina Alsowaidi and Peter Vadas

    Citation: Allergy, Asthma & Clinical Immunology 2008 4:139

    Content type: Review

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  19. Multiple factors are contributing to the expansion of ragweed on a worldwide scale. This review seeks to examine factors that may contribute to allergen expansion with reference to ragweed as a well-studied ex...

    Authors: Matthew L. Oswalt and Gailen D. Marshall Jr

    Citation: Allergy, Asthma & Clinical Immunology 2008 4:130

    Content type: Review

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  20. Chlamydophila pneumoniae and Mycoplasma pneumoniae are common pathogens causing acute illness in both the upper and lower airways. Several observations are supportive of a possible causative role of these pathoge...

    Authors: Paraskevi Xepapadaki, Ioanna Koutsoumpari, Vasiliki Papaevagelou, Christina Karagianni and Nikolaos G. Papadopoulos

    Citation: Allergy, Asthma & Clinical Immunology 2008 4:111

    Content type: Research

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  21. Allergen-specific immunotherapy (SIT) is the cornerstone of the management of allergic diseases, which targets modification of the immunologic response, along with environmental allergen avoidance and pharmaco...

    Authors: Cevdet Ozdemir, Mübeccel Akdis and Cezmi A. Akdis

    Citation: Allergy, Asthma & Clinical Immunology 2008 4:106

    Content type: Research

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  22. The use of chitosan nanoparticles as carriers for expression plasmids represents a major improvement in gene expression technology. We demonstrated previously that treatment with chitosan interferon-γ (IFN-γ) ...

    Authors: Xiaoyuan Kong, Gary R. Hellermann, Weidong Zhang, Prasanna Jena, Mukesh Kumar, Aruna Behera, Sumita Behera, Richard Lockey and Shyam S. Mohapatra

    Citation: Allergy, Asthma & Clinical Immunology 2008 4:95

    Content type: Review

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  23. Although there is much circumstantial evidence implicating eosinophils as major orchestrators in the pathophysiology of asthma, recent studies have cast doubt on their importance. Not only does anti-interleuki...

    Authors: Peter Bradding

    Citation: Allergy, Asthma & Clinical Immunology 2008 4:84

    Content type: Review

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  24. This review focuses on aspirin-exacerbated asthma (AEA). The review includes historical perspective of aspirin, prevalence, pathogenesis, clinical features and treatment of AEA. The pathogenesis of AEA involve...

    Authors: Mathew Varghese and Richard F. Lockey

    Citation: Allergy, Asthma & Clinical Immunology 2008 4:75

    Content type: Review

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  25. The present review addresses the literature regarding the sensitivity and specificity of the various diagnostic methods for evaluating non-immediate (ie, occurring more than 1 hour after drug administration) h...

    Authors: Antonino Romano, Marinella Viola, Francesco Gaeta, Gabriele Rumi and Michela Maggioletti

    Citation: Allergy, Asthma & Clinical Immunology 2008 4:66

    Content type: Review

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  26. Occupational contact dermatitis accounts for 90% of all cases of work-related cutaneous disorders. It can be divided into irritant contact dermatitis, which occurs in 80% of cases, and allergic contact dermati...

    Authors: Denis Sasseville

    Citation: Allergy, Asthma & Clinical Immunology 2008 4:59

    Content type: Review

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  27. We investigated the association between airway hyperresponsiveness (AHR) and obesity in adults referred for confirmation of asthma diagnosis. Data were analyzed for obesity class I (body mass index [BMI] 30-34...

    Authors: Sat Sharma, Adarsh Tailor, Richard Warrington and Mary Cheang

    Citation: Allergy, Asthma & Clinical Immunology 2008 4:51

    Content type: Research

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  28. The long-term effects of behaviour and environmental exposures, particularly during childhood, on health outcomes are well documented. Particularly thought provoking is the notion that exposures to different s...

    Authors: Moshe Szyf and Michael J Meaney

    Citation: Allergy, Asthma & Clinical Immunology 2008 4:37

    Content type: Research

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  29. Asthma has long been considered a condition in which psychological factors have a role. As in many illnesses, psychological variables may affect outcome in asthma via their effects on treatment adherence and s...

    Authors: Ryan J Van Lieshout and Glenda MacQueen

    Citation: Allergy, Asthma & Clinical Immunology 2008 4:12

    Content type: Research

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  30. Anticholinergics, or specific antimuscarinic agents, by inhibition of muscarinic receptors cause bronchodilatation, which might correlate with activation of these receptors by the muscarinic agonist methacholi...

    Authors: Bojana B. Petanjek, Sanja P. Grle, Dubravka Pelicarić and Dubravka Vranković

    Citation: Allergy, Asthma & Clinical Immunology 2007 3:123

    Content type: Research

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