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  1. Several primary studies evaluated the association between rhinitis and the incidence of depression and yielded inconsistent results. We conducted a meta-analysis of studies evaluating the association between r...

    Authors: Jing Wang, Dongqiong Xiao, Huayou Chen and Juan Hu
    Citation: Allergy, Asthma & Clinical Immunology 2021 17:111
  2. Intimacy-related allergic reactions, including anaphylaxis, are under-reported due to social stigma, lack of awareness, and misdiagnosis. The differential diagnosis for intimacy-related anaphylaxis is extensiv...

    Authors: Lundy R. McKibbin, Sidney Kin-Hung Siu, Hannah T. Roberts, Michael Shkrum and Samira Jeimy
    Citation: Allergy, Asthma & Clinical Immunology 2021 17:110
  3. Currently there is no systematic review and meta-analysis of the global incidence rates of anaphylactic and nonanaphylactic reactions to SARS-CoV-2 vaccines in the general adult population.

    Authors: Saad Alhumaid, Abbas Al Mutair, Zainab Al Alawi, Ali A. Rabaan, Raghavendra Tirupathi, Mohammed A. Alomari, Aqeel S. Alshakhes, Abeer M. Alshawi, Gasmelseed Y. Ahmed, Hassan M. Almusabeh, Tariq T. Alghareeb, Abdulaziz A. Alghuwainem, Zainab A. Alsulaiman, Mohammed A. Alabdulmuhsin, Emad A. AlBuwaidi, Amjad K. Bu Dukhi…
    Citation: Allergy, Asthma & Clinical Immunology 2021 17:109
  4. The Global Initiative for Asthma recommends the use of as-needed low-dose inhaled corticosteroid (ICS)-formoterol as a preferred controller therapy for patients with mild asthma. These recommendations were bas...

    Authors: Mohsen Sadatsafavi, J. Mark FitzGerald, Paul M. O’Byrne, Mena Soliman, Niroshan Sriskandarajah, Colin Vicente and Sarowar Muhammad Golam
    Citation: Allergy, Asthma & Clinical Immunology 2021 17:108
  5. Severe combined immunodeficiency (SCID) is a group of relatively rare primary immunodeficiency disorders (PIDs), characterized by disturbed development of T cells and B cells, caused by several genetic mutatio...

    Authors: Fatemeh Sadat Mahdavi, Mohammad Keramatipour, Sarina Ansari, Samin Sharafian, Arezou Karamzade and Marzieh Tavakol
    Citation: Allergy, Asthma & Clinical Immunology 2021 17:107
  6. The symptoms of patients with respiratory disease are influenced by local environmental factors. The incidence of allergic rhinitis in grassland areas was significantly higher than that in non-grassland areas....

    Authors: Xu Xu, Long Qin, Lei Ren, Chengshuo Wang, Yuan Zhang and Luo Zhang
    Citation: Allergy, Asthma & Clinical Immunology 2021 17:106
  7. Since the outbreak of the novel coronavirus disease (COVID-19), the therapeutic and management options to reduce the burden of the COVID-19 disease are under investigation. IVIG therapy is used as an effective...

    Authors: Zahra Kolahchi, Hanye Sohrabi, Sara Ekrami Nasab, Hesan Jelodari Mamaghani, Maryam Keyfari Alamdari and Nima Rezaei
    Citation: Allergy, Asthma & Clinical Immunology 2021 17:105
  8. The determination of systemic inflammatory markers is one of the important directions to study the pathogenesis of asthma and improve the diagnosis of asthma. Current studies have found that the 14-3-3 protein...

    Authors: Decai Wang, Lizong Rao, Yalan Cui, Guoting Tang, Haiming Huang, Ting Yuan and Biwen Mo
    Citation: Allergy, Asthma & Clinical Immunology 2021 17:104
  9. C1 inhibitor (C1-INH) and complement 4 (C4) have historically been referred to as positive acute phase reactants, however this has never been evaluated in hereditary angioedema (HAE) patients. Low function of ...

    Authors: Peter Stepaniuk, Ana-Maria Bosonea, Persia Pourshahnazari, Adrienne Roos and Amin Kanani
    Citation: Allergy, Asthma & Clinical Immunology 2021 17:103
  10. Knowledge is limited about the relationship between clinical reactivity to foods through breastfeeding and long-term food allergy outcomes. We explored parent-perceived symptoms of food allergy via breastfeedi...

    Authors: Abigail Lang, Shrey Patel, Karen Rychlik, Deanna Caruso, Xiaobin Wang, Jacqueline A. Pongracic and Rajesh Kumar
    Citation: Allergy, Asthma & Clinical Immunology 2021 17:102
  11. Peanut and soybean allergies are listed as contraindication in the package leaflet of isotretinoin, a widely used treatment of acne vulgaris. Cross-reactivity between PR10-proteins in peanut, tree nuts, and so...

    Authors: Anna Bamidis and Silke C. Hofmann
    Citation: Allergy, Asthma & Clinical Immunology 2021 17:101
  12. Hereditary angioedema (HAE) is a rare genetic disorder characterized by unpredictable localized episodes of edema, which is frequently managed with long-term prophylactic medications. Until recently, long-term...

    Authors: Richard G. Gower and Mary Wilber
    Citation: Allergy, Asthma & Clinical Immunology 2021 17:100
  13. Jellyfish stings are known to induce allergic skin reactions; however, case reports of anaphylaxis after jellyfish ingestion have been increasing, especially in Asian countries. Some cases of anaphylaxis after...

    Authors: Mitsuru Tsuge, Masanori Ikeda, Osamu Mitani, Masato Yasui and Hirokazu Tsukahara
    Citation: Allergy, Asthma & Clinical Immunology 2021 17:99
  14. We present a case of CVID complicated by granulomatous interstitial lung disease (GLILD). This patient clinical course was further complicated by COVID-19 infection. This is only the 2nd known case report of C...

    Authors: Debendra Pattanaik, Shaunah Ritter and Joseph Fahhoum
    Citation: Allergy, Asthma & Clinical Immunology 2021 17:98
  15. Hen’s eggs are one of the most common causes of food allergy. Although hen’s eggs are known to cause more gastrointestinal symptoms than other foods, it is not known whether there is a difference in organ-spec...

    Authors: Kei Uneoka, Satoshi Horino, Ayafumi Ozaki, Haruka Aki, Masako Toda and Katsushi Miura
    Citation: Allergy, Asthma & Clinical Immunology 2021 17:97
  16. Atopic dermatitis is the most common chronic inflammatory skin disease and presents a major public health burden worldwide. Recent observational studies revealed the potential association between atopic dermat...

    Authors: Zhiyu Lu, Ni Zeng, Yuxin Cheng, Yihe Chen, Yueyue Li, Qian Lu, Qingyue Xia and Dan Luo
    Citation: Allergy, Asthma & Clinical Immunology 2021 17:96
  17. The prevalence of comorbidities and their relation to asthma control and treatment is a topic of increasing interest, however comprehensive studies are scarce. We aimed to determine the prevalence of the most ...

    Authors: Gábor Tomisa, Alpár Horváth, Balázs Sánta, András Keglevich and Lilla Tamási
    Citation: Allergy, Asthma & Clinical Immunology 2021 17:95
  18. It is well known that atopic dermatitis (AD) is associated with other allergic diseases. Recentely, links to diseases other than allergic disease have also been actively studied. Among them, the results of stu...

    Authors: Hye Jung Jung, Dong Heon Lee, Mi Youn Park and Jiyoung Ahn
    Citation: Allergy, Asthma & Clinical Immunology 2021 17:94
  19. There is currently a dramatic increase in the number of COVID-19 cases worldwide, and further drastic restrictions in our daily life will be necessary to contain this pandemic. The implications of restrictive ...

    Authors: Nicole Maison, Heidrun Herbrüggen, Bianca Schaub, Christina Schauberger, Svenja Foth, Ruth Grychtol, Mustafa Abdo, Henrik Watz, Wilfried Nikolaizik, Klaus F. Rabe, Matthias V. Kopp, Gesine Hansen, Erika von Mutius, Thomas Bahmer and Jimmy Omony
    Citation: Allergy, Asthma & Clinical Immunology 2021 17:93
  20. Allergen extracts used in subcutaneous immunotherapy can be standardized or non-standardized. Standardized extracts are available in specific biological potencies, presumably making their biological activity m...

    Authors: Benny Dua, Jane Park and Harold Kim
    Citation: Allergy, Asthma & Clinical Immunology 2021 17:92
  21. An allergy to kiwi is rare in Poland. Most (65–72%) of the patients who are allergic to kiwi report symptoms of an oral allergy syndrome (OAS); however, systemic manifestations (18–28%) have also been reported.

    Authors: Natalia Ukleja-Sokołowska, Robert Zacniewski, Kinga Lis, Magdalena Żbikowska-Gotz, Andrzej Kuźmiński and Zbigniew Bartuzi
    Citation: Allergy, Asthma & Clinical Immunology 2021 17:91
  22. Tocilizumab has been shown to be effective for treatment of juvenile idiopathic arthritis (JIA). To our knowledge, this is the first reported case of interstitial lung disease occurring shortly after tocilizum...

    Authors: Koichi Sugihara, Risa Wakiya, Hiromi Shimada, Mikiya Kato, Tomohiro Kameda, Shusaku Nakashima, Mai Mahmoud Fahmy Mansour, Yusuke Ushio, Norimitsu Kadowaki and Hiroaki Dobashi
    Citation: Allergy, Asthma & Clinical Immunology 2021 17:90
  23. Exercise-induced anaphylaxis (EIA) is a rare and potentially life-threatening disorder that can develop independently without food ingestion. Cold drinks can also trigger symptoms in some patients with cold-in...

    Authors: Chikako Motomura, Koji Ide, Terufumi Shimoda and Hiroshi Odajima
    Citation: Allergy, Asthma & Clinical Immunology 2021 17:89
  24. Toxic epidermal necrolysis (TEN)/Stevens–Johnson syndrome (SJS) is the spectrum of severe, acute, mucocutaneous, T-cell mediated delayed type IV hypersensitivity reaction and universally related to different d...

    Authors: Biniyam A. Ayele, Kemal Ali and Eliyas Mulatu
    Citation: Allergy, Asthma & Clinical Immunology 2021 17:88
  25. A formulation of black cumin (Nigella sativa L.), licorice (Glycyrrhiza glabra L.), anise (Pimpinella anisum L.) and tea (Camellia sinensis (L.) Kuntze) (denoted BLAB tea) is traditionally used to relief allergy ...

    Authors: Chengsong Liao, Yangyang Han, Zhijing Chen and Huricha Baigude
    Citation: Allergy, Asthma & Clinical Immunology 2021 17:87
  26. Increased intestinal permeability, either due to the exposure to antigens in asthmatic patients or due to a barrier defect, plays a critical role in susceptibility to environmental allergens. House dust mite a...

    Authors: Shereen A. Baioumy, Aya Elgendy, Shereen M. Ibrahim, Sara I. Taha and Shaimaa H. Fouad
    Citation: Allergy, Asthma & Clinical Immunology 2021 17:86
  27. Leveraging the data management resources of the Canadian Primary Care Sentinel Surveillance Network (CPCSSN) is a viable approach for describing the prevalence of allergic disease documented in primary care se...

    Authors: Alexander G. Singer, Leanne Kosowan, Nerissa Nankissoor, Ryan Phung, Jennifer L. P. Protudjer and Elissa M. Abrams
    Citation: Allergy, Asthma & Clinical Immunology 2021 17:85
  28. Physical effort is capable of triggering airway obstruction in asthmatics, the so-called exercise-induced bronchoconstriction in asthma (EIBa). This study was performed in subjects with mild persistent asthma,...

    Authors: Maroon Salameh, Laura Pini, Federico Quadri, Fabio Spreafico, Damiano Bottone and Claudio Tantucci
    Citation: Allergy, Asthma & Clinical Immunology 2021 17:84
  29. Food ladders are clinical tools already widely used in Europe for food reintroduction in milk- and egg-allergic children. Previously developed milk and egg ladders have limited applicability to Canadian childr...

    Authors: Alanna Chomyn, Edmond S. Chan, Joanne Yeung, Timothy K. Vander Leek, Brock A. Williams, Lianne Soller, Elissa M. Abrams, Raymond Mak and Tiffany Wong
    Citation: Allergy, Asthma & Clinical Immunology 2021 17:83
  30. The expression profiles of the intestinal mucosa have not been comprehensively investigated in asthma. We aimed to explore this in the Correlated Expression and Disease Association Research (CEDAR) patient coh...

    Authors: Jan K. Nowak, Marzena Dworacka, Nazgul Gubaj, Arystan Dossimov, Zhumabek Dossimov and Jarosław Walkowiak
    Citation: Allergy, Asthma & Clinical Immunology 2021 17:82
  31. Drug reaction with eosinophilia and systemic symptoms (DRESS) is a potentially life-threatening hypersensitivity reaction to medication. While a relatively rare phenomenon, early identification and discontinua...

    Authors: Arman Zereshkian and Susan Waserman
    Citation: Allergy, Asthma & Clinical Immunology 2021 17:81
  32. Allergic reaction to liposomal amphotericin B is rare. We report a case of cardiac arrest in a 64-year-old woman following liposomal amphotericin B infusion, requiring resuscitation. We also present the result...

    Authors: George P. Drewett, Ana Copaescu, Joseph DeLuca, Natasha E. Holmes and Jason A. Trubiano
    Citation: Allergy, Asthma & Clinical Immunology 2021 17:80
  33. Insulin hypersensitivity is rare, but challenging for individuals with diabetes. The prevalence of insulin allergy has decreased since the introduction of human recombinant insulin preparations. Hypersensitivi...

    Authors: Babak Aberumand and Samira Jeimy
    Citation: Allergy, Asthma & Clinical Immunology 2021 17:79
  34. Hereditary angioedema (HAE) is a rare autosomal dominant disease resulting in recurring episodes of swelling, leading to considerable patient morbidity and mortality. Lanadelumab is a plasma kallikrein inhibit...

    Authors: Aled Iaboni, Amin Kanani, Gina Lacuesta, Christine Song, Manstein Kan and Stephen D. Betschel
    Citation: Allergy, Asthma & Clinical Immunology 2021 17:78
  35. Body mass index (BMI) is associated with asthma but associations of BMI temporal patterns with asthma incidence are unclear. Previous studies suggest that DNA methylation (DNAm) is associated with asthma statu...

    Authors: Rutu Rathod, Hongmei Zhang, Wilfried Karmaus, Susan Ewart, Latha Kadalayil, Caroline Relton, Susan Ring, S. Hasan Arshad and John W. Holloway
    Citation: Allergy, Asthma & Clinical Immunology 2021 17:77
  36. Shrimp allergy is a growing problem among the European population. TSLP, IL-25 and IL-33 are involved in the pathophysiology of allergic diseases, including asthma and atopic dermatitis, as they activate the T...

    Authors: Natalia Ukleja-Sokołowska, Magdalena Żbikowska-Gotz, Kinga Lis, Rafał Adamczak and Zbigniew Bartuzi
    Citation: Allergy, Asthma & Clinical Immunology 2021 17:76
  37. Currently, several biologics are used for the treatment of cutaneous pathologies such as atopic dermatitis (AD), psoriasis or skin cancers. The main administration routes are subcutaneous and intravenous injec...

    Authors: Audrey Baylet, Raoul Vyumvuhore, Marine Laclaverie, Laëtitia Marchand, Carine Mainzer, Sylvie Bordes, Brigitte Closs-Gonthier and Laurent Delpy
    Citation: Allergy, Asthma & Clinical Immunology 2021 17:73
  38. We conducted a nationwide Canadian telephone survey on food allergy prevalence between February 2016 and January 2017, targeting vulnerable populations (New, Indigenous, and lower-income Canadians).

    Authors: Ann E. Clarke, Susan J. Elliott, Yvan St. Pierre, Lianne Soller, Sebastien La Vieille and Moshe Ben-Shoshan
    Citation: Allergy, Asthma & Clinical Immunology 2021 17:72
  39. Most Canadian food allergy data has focused on Health Canada’s priority food allergens. This study describes which non-priority (emerging) food allergens were most commonly reported by Canadian parents and cat...

    Authors: Lianne Soller, Sebastien La Vieille, Scott B. Cameron, Raymond Mak, Victoria E. Cook, Jennifer Gerdts and Edmond S. Chan
    Citation: Allergy, Asthma & Clinical Immunology 2021 17:71
  40. Glucocorticoids rarely cause anaphylaxis. Common methods for the determination of allergens include in vivo skin prick test (SPT) and intradermal skin test (IDST) and the in vitro basophil activation test (BAT...

    Authors: Hitomi Amano, Yoshiro Kitagawa, Tomohito Hayakawa, Taichiro Muto, Akihisa Okumura and Hideyuki Iwayama
    Citation: Allergy, Asthma & Clinical Immunology 2021 17:70
  41. IL13, IL4, IL4RA, FCER1B and ADRB2 are susceptible genes of asthma and atopy. Our previous study has found gene–gene interactions on asthma between these genes in Chinese Han children. Whether the interactions be...

    Authors: Li Hua, Quanhua Liu, Jing Li, Xianbo Zuo, Qian Chen, Jingyang Li, Yuwei Wang, Haipei Liu, Zhaobo Shen, Yi Li, Zenan Ma, Shengdong Dong, Ruoxu Ji, Dingzhu Fang, Yi Chen, Wenwei Zhong…
    Citation: Allergy, Asthma & Clinical Immunology 2021 17:69
  42. We recently showed that multicomponent traditional Chinese medicine (TCM) therapy had steroid-sparing effects in moderate-to-severe eczema. We sought to evaluate TCM effects in severe eczema in a 7-year-old ma...

    Authors: Serife Uzun, Zixi Wang, Tory A. McKnight, Paul Ehrlich, Erin Thanik, Anna Nowak-Wegrzyn, Nan Yang and Xiu-Min Li
    Citation: Allergy, Asthma & Clinical Immunology 2021 17:68
  43. A significant portion of COVID-19 sufferers have asthma. The impacts of asthma on COVID-19 progression are still unclear but a modifying effect is plausible as respiratory viruses are acknowledged to be an imp...

    Authors: Jian Luo, Yi-Ling Chen, Wentao Chen, David A. Duncan, Alexander Mentzer, Julian C. Knight, Graham Ogg, Paul Klenerman, Ian D. Pavord and Luzheng Xue
    Citation: Allergy, Asthma & Clinical Immunology 2021 17:67
  44. A cost-minimization analysis (CMA) was performed to evaluate the economic implications of introducing the SQ Tree sublingual immunotherapy (SLIT)-tablets marketed as ITULATEK® (Health Canada regulatory approva...

    Authors: Anne K. Ellis, Rémi Gagnon, Eva Hammerby, Julia Shen and Sheena Gosain
    Citation: Allergy, Asthma & Clinical Immunology 2021 17:66
  45. Subcutaneous immunotherapy (SCIT) is an effective treatment for allergic rhinoconjunctivitis. However, adverse events, including life-threatening systemic reactions, may occur. The purpose of this project is t...

    Authors: Adam Aue, Joella Ho, Rongbo Zhu, Harold Kim and Samira Jeimy
    Citation: Allergy, Asthma & Clinical Immunology 2021 17:65
  46. On Wright-stained sputum cytospins, eosinophil differential of ≥ 1.2% is considered abnormal, and ≥ 2.3% identifies an eosinophilic endotype. We hypothesized that failure to consider free eosinophil granules (...

    Authors: Melanie Kjarsgaard, Adil Adatia, Anurag Bhalla, Nicola LaVigne, Katherine Radford, Chynna Huang, Manali Mukherjee and Parameswaran Nair
    Citation: Allergy, Asthma & Clinical Immunology 2021 17:63

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