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  1. Because atopic dermatitis does not heal completely, associated severe atopic keratoconjunctivitis (AKC) and vernal keratoconjunctivitis (VKC) often require long-term treatment. This study aims to evaluate the ...

    Authors: Hiroyuki Yazu, Kazumi Fukagawa, Eisuke Shimizu, Yasunori Sato and Hiroshi Fujishima
    Citation: Allergy, Asthma & Clinical Immunology 2021 17:11
  2. Polyvalent Mechanical Bacterial Lysate (PMBL®) contains antigens of bacteria responsible for respiratory infections. PMBL® has been proven to reduce the number of respiratory infections, and in its use, immuno...

    Authors: Małgorzata Bartkowiak-Emeryk, Andrzej Emeryk, Jacek Roliński, Ewelina Wawryk-Gawda and Ewa Markut-Miotła
    Citation: Allergy, Asthma & Clinical Immunology 2021 17:10
  3. X-linked hypohidrotic ectodermal dysplasia (XLHED) is the most common form of ectodermal dysplasia. Clinical and genetic heterogeneity between different ectodermal dysplasia types and evidence of incomplete pe...

    Authors: Bhavi P. Modi, Kate L. Del Bel, Susan Lin, Mehul Sharma, Phillip A. Richmond, Clara D. M. van Karnebeek, Edmond S. Chan, Vishal Avinashi, Wingfield E. Rehmus, Catherine M. Biggs, Wyeth W. Wasserman and Stuart E. Turvey
    Citation: Allergy, Asthma & Clinical Immunology 2021 17:9
  4. Severe coronavirus disease-19 (COVID-19) presents with progressive dyspnea, which results from acute lung inflammatory edema leading to hypoxia. As with other infectious diseases that affect the respiratory tr...

    Authors: Natália F. Mendes, Carlos P. Jara, Eli Mansour, Eliana P. Araújo and Licio A. Velloso
    Citation: Allergy, Asthma & Clinical Immunology 2021 17:5
  5. The pathogenetic mechanisms of neutrophilic asthma are not well understood now. Whether T helper (Th)17-mediated immunity contributes to the pathogenesis of neutrophilic asthma in human is still under investig...

    Authors: Qing Wei, Jing Liao, Min Jiang, Jing Liu, Xiuan Liang and Guangmin Nong
    Citation: Allergy, Asthma & Clinical Immunology 2021 17:4
  6. Mepolizumab and benralizumab are biologics approved for severe eosinophilic asthma. Mepolizumab is an anti-interlukin-5 (IL-5) antibody while benralizumab is an anti-interleukin-5 receptor alpha (IL-5Rα) antib...

    Authors: Arian Ghassemian, Jane Jiyoon Park, Michael W. Tsoulis and Harold Kim
    Citation: Allergy, Asthma & Clinical Immunology 2021 17:3
  7. Egg allergy is one of the most common food allergies in children. To date, oral immunotherapy (OIT) has been considered as a promising treatment option for egg allergy. However, safety issues remain concerning...

    Authors: Nagatoshi Sagara, Satoshi Fujita, Ryohei Suzuki, Akiko Aota, Kenichi Akashi and Toshio Katsunuma
    Citation: Allergy, Asthma & Clinical Immunology 2021 17:2
  8. Beta-lactam allergy is reported in 5–10% of children in North America, but up to 94–97% of patients are deemed not allergic after allergist assessment. The utility of standardized skin testing for penicillin a...

    Authors: Hannah Roberts, Lianne Soller, Karen Ng, Edmond S. Chan, Ashley Roberts, Kristopher Kang, Kyla J. Hildebrand and Tiffany Wong
    Citation: Allergy, Asthma & Clinical Immunology 2020 16:103
  9. Penicillins and other β-lactam antibiotics are the most common elicitors of allergic drug reaction. However, data on the pattern of clinical reaction types elicited by specific β-lactams are scarce and inconsi...

    Authors: Philipp Schrüfer, Knut Brockow, Johanna Stoevesandt and Axel Trautmann
    Citation: Allergy, Asthma & Clinical Immunology 2020 16:102
  10. Femtosecond laser corneal refractive surgery is generally considered safe and effective; however, this procedure is rarely associated with severe allergic reactions. We reported a rare case of hypersensitivity...

    Authors: Jiaonan Ma, Lin Zhang, Mengdi Li and Yan Wang
    Citation: Allergy, Asthma & Clinical Immunology 2020 16:101
  11. Olaparib is a revolutionary treatment for patients with ovarian and breast cancer. Currently, there is no established 1-day drug desensitization protocol for patients with olaparib type-1 hypersensitivity reac...

    Authors: Rongbo Zhu, Stephen Welch and Hannah Roberts
    Citation: Allergy, Asthma & Clinical Immunology 2020 16:100
  12. Food protein-induced enterocolitis (FPIES), an entity previously thought to only affect children, has been increasingly described in adults. In this study, we report a Canadian cohort of 19 adolescents and adu...

    Authors: Daniel H. Li, Andrew Wong-Pack, Andrea Leilani Macikunas and Harold Kim
    Citation: Allergy, Asthma & Clinical Immunology 2020 16:99
  13. The study aimed to determine the prevalence and risk factors of allergic rhinitis and related comorbidities in school-age children in Budapest, capital of Hungary. Data and epidemiological studies on this dise...

    Authors: Monika Sultész, Alpár Horváth, Dávid Molnár, Gábor Katona, Györgyi Mezei, Andor Hirschberg and Gabriella Gálffy
    Citation: Allergy, Asthma & Clinical Immunology 2020 16:98
  14. This is a retrospective review of the Winnipeg Regional Health Authority’s (WRHA) angioedema patients who were dispensed icatibant in hospital. Icatibant is a bradykinin B2 receptor antagonist indicated for He...

    Authors: George Cai, Colin Barber and Chrystyna Kalicinsky
    Citation: Allergy, Asthma & Clinical Immunology 2020 16:96
  15. The vast majority of individuals labelled as allergic are not deemed truly allergic upon appropriate assessment by an allergist. A label of beta-lactam allergy carries important risks for individual and public...

    Authors: Samira Jeimy, Moshe Ben-Shoshan, Elissa M. Abrams, Anne K. Ellis, Lori Connors and Tiffany Wong
    Citation: Allergy, Asthma & Clinical Immunology 2020 16:95
  16. Asthma has been shown to be related to an increased risk of invasive pneumococcal disease (IPD), although the results remain inconclusive. Therefore, we performed a meta-analysis to determine whether asthma in...

    Authors: Lingling Li, Yusheng Cheng, Xiongwen Tu, Jie Yang, Chenghui Wang, Min Zhang and Zhiwei Lu
    Citation: Allergy, Asthma & Clinical Immunology 2020 16:94
  17. Subcutaneous immunotherapy (SCIT) is the standard approach for treating patients with sensitizations to aeroallergens. However, immunotherapy can trigger severe systemic reactions if delivered inappropriately ...

    Authors: Kara Robertson, Nazanin Montazeri, Urvashi Shelke, Samira Jeimy and Harold Kim
    Citation: Allergy, Asthma & Clinical Immunology 2020 16:93
  18. This differential diagnosis of allergic vs non-allergic asthma is typically made on the basis of sensitization to allergens, such that absence of sensitization could result in a patient being managed as having...

    Authors: Dirk Koschel, Claudia Mailänder, Inessa Schwab Sauerbeck and Jens Schreiber
    Citation: Allergy, Asthma & Clinical Immunology 2020 16:92
  19. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Renata Calciolari Rossi, Raquel Annoni, Diogenes Seraphim Ferreira, Luiz Fernando Ferraz da Silva and Thais Mauad
    Citation: Allergy, Asthma & Clinical Immunology 2020 16:91

    The original article was published in Allergy, Asthma & Clinical Immunology 2019 15:50

  20. Eosinophilic granulomatosis with polyangiitis (EGPA) is a systemic necrotizing vasculitis mainly affecting small-sized arteries. Involvement of medium-sized vessels is very rare in EGPA. Here we present the ca...

    Authors: Eunsil Koh, Noeul Kang, Jin-Young Lee, Duk-Kyung Kim, Young Soo Do, Byung-Jae Lee and Dong-Chull Choi
    Citation: Allergy, Asthma & Clinical Immunology 2020 16:90
  21. Vitamin D (VitD) can regulate immune responses and maternal VitD-deficiency can affect immune responses in the offspring. This study aimed at investigating the effects of maternal VitD-deficiency during pregna...

    Authors: Fei Huang, Yang-hua Ju, Hong-bo Wang and Ya-nan Li
    Citation: Allergy, Asthma & Clinical Immunology 2020 16:89
  22. Longer time to diagnosis for patients with eosinophilic esophagitis can lead to adverse patient outcomes, but the length of diagnostic delay has not been quantified for patients with eosinophilic esophagitis i...

    Authors: Jocelyn Jia, Edmond S. Chan, Vishal Avinashi, Elaine Hsu, Hin Hin Ko and Lianne Soller
    Citation: Allergy, Asthma & Clinical Immunology 2020 16:88
  23. Asthma is a chronic respiratory disease characterized by reversible bronchoconstriction and airway inflammation. According to Statistics Canada in 2014, 8.1% of Canadians aged 12 and older reported having asth...

    Authors: Ana-Maria Bosonea, Heather Sharpe, Ting Wang, Jeffrey A. Bakal, A. Dean Befus, Lawrence W. Svenson and Harissios Vliagoftis
    Citation: Allergy, Asthma & Clinical Immunology 2020 16:87
  24. Peanut allergy (PA) has increased in developed countries and can have a dramatic effect on quality of life but data surrounding this is limited in France. Allergy to Peanuts imPacting Emotions And Life study (...

    Authors: Pascale Couratier, Romain Montagne, Sarah Acaster, Katy Gallop, Ram Patel, Andrea Vereda and Guillaume Pouessel
    Citation: Allergy, Asthma & Clinical Immunology 2020 16:86
  25. A few studies have reported the association between asthma and osteoporosis. We aimed to analyze the association of asthma and its subgroups with osteoporosis in the Korean adult population.

    Authors: Jee Hye Wee, Chanyang Min, Min Woo Park, Soo Hwan Byun, Hyo-Jeong Lee, Bumjung Park and Hyo Geun Choi
    Citation: Allergy, Asthma & Clinical Immunology 2020 16:84
  26. Limited previous research has assessed the psychosocial burden and productivity impact of caring for a child with peanut allergy and factors associated with burden. The objective of this research was to explor...

    Authors: Sarah Acaster, Katy Gallop, Jane de Vries, Anne Marciniak, Robert Ryan, Andrea Vereda and Rebecca Knibb
    Citation: Allergy, Asthma & Clinical Immunology 2020 16:83
  27. Eosinophilic chronic rhinosinusitis with nasal polyps (ECRSwNP) exhibits a poorer outcome compared with non-eosinophilic chronic rhinosinusitis with nasal polyps (nonECRSwNP), so it is significant to identify ...

    Authors: Zhuoping Liang, Bing Yan, Chang Liu, Ruyu Tan, Chengshuo Wang and Luo Zhang
    Citation: Allergy, Asthma & Clinical Immunology 2020 16:82
  28. Omalizumab is an efficient drug for patients with uncontrolled severe allergic asthma (SAA). However, little is known about the differences in omalizumab treatment outcomes among patients with different types ...

    Authors: Petr Vaník, Jakub Novosad, Olga Kirchnerová, Irena Krčmová and Milan Teřl
    Citation: Allergy, Asthma & Clinical Immunology 2020 16:81
  29. Primary immunodeficiencies (PID) constitute a heterogeneous group of more than 350 monogenetic diseases. PID patients with antibody impairment require lifelong administration of immunoglobulin G replacement th...

    Authors: Viviana Moschese, Clementina Canessa, Antonino Trizzino, Baldassarre Martire, Giorgio Maria Boggia and Simona Graziani
    Citation: Allergy, Asthma & Clinical Immunology 2020 16:80
  30. Penicillin allergy is frequently reported in adults and children. Recent studies suggest that microbiota plays a key role in the development and progression of allergy. In this study, the relationship between ...

    Authors: Xiaohua Li, Jun Luo, Chuan Nie, Qingxia Li, Xiaofeng Sun, Hongping Li and Yong Zhang
    Citation: Allergy, Asthma & Clinical Immunology 2020 16:79
  31. Allergic bronchopulmonary aspergillosis (ABPA) reflects hypersensitivity and an exaggerated immune response to Aspergillus fumigatus. ABPA typically occurs in individuals with airway diseases such as asthma or cy...

    Authors: Kevin S. K. Lau, Chantane Yeung and Chris Carlsten
    Citation: Allergy, Asthma & Clinical Immunology 2020 16:78
  32. Interferon-stimulated gene 15 (ISG15) was the first ubiquitin-like modifier protein identified that acts by protein conjugation (ISGylation) and is thought to modulate IFN-induced inflammation. Here, we report a ...

    Authors: Guadalupe Buda, Rita María Valdez, German Biagioli, Federico A. Olivieri, Nicolás Affranchino, Carolina Bouso, Vanesa Lotersztein, Dusan Bogunovic, Jacinta Bustamante and Marcelo A. Martí
    Citation: Allergy, Asthma & Clinical Immunology 2020 16:77
  33. “Immune boosting” is a trending topic during the COVID-19 pandemic. The concept of “immune boosting” is scientifically misleading and often used to market unproven products and therapies. This paper presents a...

    Authors: Darren N. Wagner, Alessandro R. Marcon and Timothy Caulfield
    Citation: Allergy, Asthma & Clinical Immunology 2020 16:76
  34. Asthma is a common chronic disease characterized by episodic or persistent respiratory symptoms and airflow limitation. Asthma treatment is based on a stepwise and control-based approach that involves an itera...

    Authors: Alberto Papi, Francesco Blasi, Giorgio Walter Canonica, Luca Morandi, Luca Richeldi and Andrea Rossi
    Citation: Allergy, Asthma & Clinical Immunology 2020 16:75
  35. Despite the clinical importance of pollen allergens among Filipinos, few studies delve into the sensitization profiles of Filipinos against pollen allergens. This study determined the sensitization profile of ...

    Authors: Maureen Sabit, Cecil Wong, Agnes Andaya and John Donnie Ramos
    Citation: Allergy, Asthma & Clinical Immunology 2020 16:74
  36. Work-related asthma (WRA) accounts for up to 25% of all adults with asthma. Early diagnosis is key for optimal management as delays in diagnosis are associated with worse outcomes. However, WRA is significantl...

    Authors: Madison MacKinnon, Teresa To, Clare Ramsey, Catherine Lemière and M. Diane Lougheed
    Citation: Allergy, Asthma & Clinical Immunology 2020 16:73
  37. Non-communicable diseases, such as allergies, are influenced by both genetic and epigenetic factors. Perinatal determinants conceivably modify the epigenetic makeup of the developing fetal immune system preven...

    Authors: Samuel Schäfer, Anthony Liu, Dianne Campbell and Ralph Nanan
    Citation: Allergy, Asthma & Clinical Immunology 2020 16:71
  38. We present a case of the patient, who developed hypersensitivity reaction during the treatment of chronic lymphocytic leukemia. Bendamustine was suspected as a culprit agent. The patient as well as 3 controls ...

    Authors: Laura Malinauskiene, Kestutis Cerniauskas, Kotryna Linauskiene, Linas Griguola, Anzelika Chomiciene and Audra Blaziene
    Citation: Allergy, Asthma & Clinical Immunology 2020 16:70
  39. Substantial experimental studies suggest a role for helminthes infections in the pathogenesis of allergies, but epidemiologic data have been inconsistent. Unlike to asthma, the association between helminthes i...

    Authors: Iraj Mohammadzadeh, Sorena Darvish, Seyed Mohammad Riahi, Solmaz Alizadeh Moghaddam, Mohammad Pournasrollah, Mousa Mohammadnia-Afrozi and Ali Rostami
    Citation: Allergy, Asthma & Clinical Immunology 2020 16:69
  40. Adherence to asthma treatment among children is usually poor. We sought to explore whether electronic adherence monitoring combined with weekly feedback regarding adherence along with a reminder to use inhaled...

    Authors: Jiande Chen, Juan Xu, Liebin Zhao, Jing Zhang, Yong Yin and Fen Zhang
    Citation: Allergy, Asthma & Clinical Immunology 2020 16:68
  41. Human microbiota plays a fundamental role in modulating the immune response. Western environment and lifestyle are envisaged to alter the human microbiota with a new microbiome profile established in Chinese i...

    Authors: Jing Guo, Xiaoping Zhang, Aarti Saiganesh, Christopher Peacock, Shu Chen, Gary A. Dykes, Belinda J. Hales, Peter N. Le Souëf and Guicheng Zhang
    Citation: Allergy, Asthma & Clinical Immunology 2020 16:67
  42. Asthma is a disease characterised by hyper responsiveness and bronchoconstriction of airways, and is a major health burden globally. A dysfunction of the oxidant-antioxidant balance, termed oxidative stress, h...

    Authors: Yenuli Fernando, Pujitha Wickramasinghe, Udani De Silva, Malintha Alahakoon, K. W. D. A. Anuradha and Shiroma Handunnetti
    Citation: Allergy, Asthma & Clinical Immunology 2020 16:66
  43. Loss-of-function (LOF) mutations in signal transducer and activator of transcription 3 (STAT3) is one of the causes of STAT3 hyperimmunoglobulin E (IgE) syndrome (STAT3-HIES), while gain-of-function (GOF) muta...

    Authors: Li Lin, Ying Wang, Bijun Sun, Luyao Liu, Wenjing Ying, Wenjie Wang, Qinhua Zhou, Jia Hou, Haili Yao, Liyuan Hu, Jinqiao Sun and Xiaochuan Wang
    Citation: Allergy, Asthma & Clinical Immunology 2020 16:65

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