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  1. Mepolizumab and benralizumab are biologics approved for severe eosinophilic asthma. Mepolizumab is an anti-interlukin-5 (IL-5) antibody while benralizumab is an anti-interleukin-5 receptor alpha (IL-5Rα) antib...

    Authors: Arian Ghassemian, Jane Jiyoon Park, Michael W. Tsoulis and Harold Kim
    Citation: Allergy, Asthma & Clinical Immunology 2021 17:3
    Content type: Letter to the editor Published on:

  3. Beta-lactam allergy is reported in 5–10% of children in North America, but up to 94–97% of patients are deemed not allergic after allergist assessment. The utility of standardized skin testing for penicillin a...

    Authors: Hannah Roberts, Lianne Soller, Karen Ng, Edmond S. Chan, Ashley Roberts, Kristopher Kang, Kyla J. Hildebrand and Tiffany Wong
    Citation: Allergy, Asthma & Clinical Immunology 2020 16:103
    Content type: Letter to the editor Published on:

  4. Penicillins and other β-lactam antibiotics are the most common elicitors of allergic drug reaction. However, data on the pattern of clinical reaction types elicited by specific β-lactams are scarce and inconsi...

    Authors: Philipp Schrüfer, Knut Brockow, Johanna Stoevesandt and Axel Trautmann
    Citation: Allergy, Asthma & Clinical Immunology 2020 16:102
    Content type: Research Published on:

  5. Femtosecond laser corneal refractive surgery is generally considered safe and effective; however, this procedure is rarely associated with severe allergic reactions. We reported a rare case of hypersensitivity...

    Authors: Jiaonan Ma, Lin Zhang, Mengdi Li and Yan Wang
    Citation: Allergy, Asthma & Clinical Immunology 2020 16:101
    Content type: Case report Published on:

  6. Olaparib is a revolutionary treatment for patients with ovarian and breast cancer. Currently, there is no established 1-day drug desensitization protocol for patients with olaparib type-1 hypersensitivity reac...

    Authors: Rongbo Zhu, Stephen Welch and Hannah Roberts
    Citation: Allergy, Asthma & Clinical Immunology 2020 16:100
    Content type: Case report Published on:

  7. Food protein-induced enterocolitis (FPIES), an entity previously thought to only affect children, has been increasingly described in adults. In this study, we report a Canadian cohort of 19 adolescents and adu...

    Authors: Daniel H. Li, Andrew Wong-Pack, Andrea Leilani Macikunas and Harold Kim
    Citation: Allergy, Asthma & Clinical Immunology 2020 16:99
    Content type: Research Published on:

  8. The study aimed to determine the prevalence and risk factors of allergic rhinitis and related comorbidities in school-age children in Budapest, capital of Hungary. Data and epidemiological studies on this dise...

    Authors: Monika Sultész, Alpár Horváth, Dávid Molnár, Gábor Katona, Györgyi Mezei, Andor Hirschberg and Gabriella Gálffy
    Citation: Allergy, Asthma & Clinical Immunology 2020 16:98
    Content type: Research Published on:

  10. This is a retrospective review of the Winnipeg Regional Health Authority’s (WRHA) angioedema patients who were dispensed icatibant in hospital. Icatibant is a bradykinin B2 receptor antagonist indicated for He...

    Authors: George Cai, Colin Barber and Chrystyna Kalicinsky
    Citation: Allergy, Asthma & Clinical Immunology 2020 16:96
    Content type: Research Published on:

  11. The vast majority of individuals labelled as allergic are not deemed truly allergic upon appropriate assessment by an allergist. A label of beta-lactam allergy carries important risks for individual and public...

    Authors: Samira Jeimy, Moshe Ben-Shoshan, Elissa M. Abrams, Anne K. Ellis, Lori Connors and Tiffany Wong
    Citation: Allergy, Asthma & Clinical Immunology 2020 16:95
    Content type: Review Published on:

  12. Asthma has been shown to be related to an increased risk of invasive pneumococcal disease (IPD), although the results remain inconclusive. Therefore, we performed a meta-analysis to determine whether asthma in...

    Authors: Lingling Li, Yusheng Cheng, Xiongwen Tu, Jie Yang, Chenghui Wang, Min Zhang and Zhiwei Lu
    Citation: Allergy, Asthma & Clinical Immunology 2020 16:94
    Content type: Review Published on:

  13. Subcutaneous immunotherapy (SCIT) is the standard approach for treating patients with sensitizations to aeroallergens. However, immunotherapy can trigger severe systemic reactions if delivered inappropriately ...

    Authors: Kara Robertson, Nazanin Montazeri, Urvashi Shelke, Samira Jeimy and Harold Kim
    Citation: Allergy, Asthma & Clinical Immunology 2020 16:93
    Content type: Research Published on:

  14. This differential diagnosis of allergic vs non-allergic asthma is typically made on the basis of sensitization to allergens, such that absence of sensitization could result in a patient being managed as having...

    Authors: Dirk Koschel, Claudia Mailänder, Inessa Schwab Sauerbeck and Jens Schreiber
    Citation: Allergy, Asthma & Clinical Immunology 2020 16:92
    Content type: Research Published on:

  15. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Renata Calciolari Rossi, Raquel Annoni, Diogenes Seraphim Ferreira, Luiz Fernando Ferraz da Silva and Thais Mauad
    Citation: Allergy, Asthma & Clinical Immunology 2020 16:91
    Content type: Correction Published on:

    The original article was published in Allergy, Asthma & Clinical Immunology 2019 15:50

  16. Eosinophilic granulomatosis with polyangiitis (EGPA) is a systemic necrotizing vasculitis mainly affecting small-sized arteries. Involvement of medium-sized vessels is very rare in EGPA. Here we present the ca...

    Authors: Eunsil Koh, Noeul Kang, Jin-Young Lee, Duk-Kyung Kim, Young Soo Do, Byung-Jae Lee and Dong-Chull Choi
    Citation: Allergy, Asthma & Clinical Immunology 2020 16:90
    Content type: Case report Published on:

  17. Vitamin D (VitD) can regulate immune responses and maternal VitD-deficiency can affect immune responses in the offspring. This study aimed at investigating the effects of maternal VitD-deficiency during pregna...

    Authors: Fei Huang, Yang-hua Ju, Hong-bo Wang and Ya-nan Li
    Citation: Allergy, Asthma & Clinical Immunology 2020 16:89
    Content type: Research Published on:

  18. Longer time to diagnosis for patients with eosinophilic esophagitis can lead to adverse patient outcomes, but the length of diagnostic delay has not been quantified for patients with eosinophilic esophagitis i...

    Authors: Jocelyn Jia, Edmond S. Chan, Vishal Avinashi, Elaine Hsu, Hin Hin Ko and Lianne Soller
    Citation: Allergy, Asthma & Clinical Immunology 2020 16:88
    Content type: Letter to the editor Published on:

  19. Asthma is a chronic respiratory disease characterized by reversible bronchoconstriction and airway inflammation. According to Statistics Canada in 2014, 8.1% of Canadians aged 12 and older reported having asth...

    Authors: Ana-Maria Bosonea, Heather Sharpe, Ting Wang, Jeffrey A. Bakal, A. Dean Befus, Lawrence W. Svenson and Harissios Vliagoftis
    Citation: Allergy, Asthma & Clinical Immunology 2020 16:87
    Content type: Research Published on:

  20. Peanut allergy (PA) has increased in developed countries and can have a dramatic effect on quality of life but data surrounding this is limited in France. Allergy to Peanuts imPacting Emotions And Life study (...

    Authors: Pascale Couratier, Romain Montagne, Sarah Acaster, Katy Gallop, Ram Patel, Andrea Vereda and Guillaume Pouessel
    Citation: Allergy, Asthma & Clinical Immunology 2020 16:86
    Content type: Research Published on:

  22. A few studies have reported the association between asthma and osteoporosis. We aimed to analyze the association of asthma and its subgroups with osteoporosis in the Korean adult population.

    Authors: Jee Hye Wee, Chanyang Min, Min Woo Park, Soo Hwan Byun, Hyo-Jeong Lee, Bumjung Park and Hyo Geun Choi
    Citation: Allergy, Asthma & Clinical Immunology 2020 16:84
    Content type: Research Published on:

  23. Limited previous research has assessed the psychosocial burden and productivity impact of caring for a child with peanut allergy and factors associated with burden. The objective of this research was to explor...

    Authors: Sarah Acaster, Katy Gallop, Jane de Vries, Anne Marciniak, Robert Ryan, Andrea Vereda and Rebecca Knibb
    Citation: Allergy, Asthma & Clinical Immunology 2020 16:83
    Content type: Research Published on:

  24. Eosinophilic chronic rhinosinusitis with nasal polyps (ECRSwNP) exhibits a poorer outcome compared with non-eosinophilic chronic rhinosinusitis with nasal polyps (nonECRSwNP), so it is significant to identify ...

    Authors: Zhuoping Liang, Bing Yan, Chang Liu, Ruyu Tan, Chengshuo Wang and Luo Zhang
    Citation: Allergy, Asthma & Clinical Immunology 2020 16:82
    Content type: Research Published on:

  25. Omalizumab is an efficient drug for patients with uncontrolled severe allergic asthma (SAA). However, little is known about the differences in omalizumab treatment outcomes among patients with different types ...

    Authors: Petr Vaník, Jakub Novosad, Olga Kirchnerová, Irena Krčmová and Milan Teřl
    Citation: Allergy, Asthma & Clinical Immunology 2020 16:81
    Content type: Research Published on:

  26. Primary immunodeficiencies (PID) constitute a heterogeneous group of more than 350 monogenetic diseases. PID patients with antibody impairment require lifelong administration of immunoglobulin G replacement th...

    Authors: Viviana Moschese, Clementina Canessa, Antonino Trizzino, Baldassarre Martire, Giorgio Maria Boggia and Simona Graziani
    Citation: Allergy, Asthma & Clinical Immunology 2020 16:80
    Content type: Short report Published on:

  27. Penicillin allergy is frequently reported in adults and children. Recent studies suggest that microbiota plays a key role in the development and progression of allergy. In this study, the relationship between ...

    Authors: Xiaohua Li, Jun Luo, Chuan Nie, Qingxia Li, Xiaofeng Sun, Hongping Li and Yong Zhang
    Citation: Allergy, Asthma & Clinical Immunology 2020 16:79
    Content type: Research Published on:

  28. Allergic bronchopulmonary aspergillosis (ABPA) reflects hypersensitivity and an exaggerated immune response to Aspergillus fumigatus. ABPA typically occurs in individuals with airway diseases such as asthma or cy...

    Authors: Kevin S. K. Lau, Chantane Yeung and Chris Carlsten
    Citation: Allergy, Asthma & Clinical Immunology 2020 16:78
    Content type: Research Published on:

  29. Interferon-stimulated gene 15 (ISG15) was the first ubiquitin-like modifier protein identified that acts by protein conjugation (ISGylation) and is thought to modulate IFN-induced inflammation. Here, we report a ...

    Authors: Guadalupe Buda, Rita María Valdez, German Biagioli, Federico A. Olivieri, Nicolás Affranchino, Carolina Bouso, Vanesa Lotersztein, Dusan Bogunovic, Jacinta Bustamante and Marcelo A. Martí
    Citation: Allergy, Asthma & Clinical Immunology 2020 16:77
    Content type: Letter to the editor Published on:

  30. “Immune boosting” is a trending topic during the COVID-19 pandemic. The concept of “immune boosting” is scientifically misleading and often used to market unproven products and therapies. This paper presents a...

    Authors: Darren N. Wagner, Alessandro R. Marcon and Timothy Caulfield
    Citation: Allergy, Asthma & Clinical Immunology 2020 16:76
    Content type: Letter to the editor Published on:

  31. Asthma is a common chronic disease characterized by episodic or persistent respiratory symptoms and airflow limitation. Asthma treatment is based on a stepwise and control-based approach that involves an itera...

    Authors: Alberto Papi, Francesco Blasi, Giorgio Walter Canonica, Luca Morandi, Luca Richeldi and Andrea Rossi
    Citation: Allergy, Asthma & Clinical Immunology 2020 16:75
    Content type: Review Published on:

  32. Despite the clinical importance of pollen allergens among Filipinos, few studies delve into the sensitization profiles of Filipinos against pollen allergens. This study determined the sensitization profile of ...

    Authors: Maureen Sabit, Cecil Wong, Agnes Andaya and John Donnie Ramos
    Citation: Allergy, Asthma & Clinical Immunology 2020 16:74
    Content type: Research Published on:

  33. Work-related asthma (WRA) accounts for up to 25% of all adults with asthma. Early diagnosis is key for optimal management as delays in diagnosis are associated with worse outcomes. However, WRA is significantl...

    Authors: Madison MacKinnon, Teresa To, Clare Ramsey, Catherine Lemière and M. Diane Lougheed
    Citation: Allergy, Asthma & Clinical Immunology 2020 16:73
    Content type: Review Published on:

  35. Non-communicable diseases, such as allergies, are influenced by both genetic and epigenetic factors. Perinatal determinants conceivably modify the epigenetic makeup of the developing fetal immune system preven...

    Authors: Samuel Schäfer, Anthony Liu, Dianne Campbell and Ralph Nanan
    Citation: Allergy, Asthma & Clinical Immunology 2020 16:71
    Content type: Research Published on:

  36. We present a case of the patient, who developed hypersensitivity reaction during the treatment of chronic lymphocytic leukemia. Bendamustine was suspected as a culprit agent. The patient as well as 3 controls ...

    Authors: Laura Malinauskiene, Kestutis Cerniauskas, Kotryna Linauskiene, Linas Griguola, Anzelika Chomiciene and Audra Blaziene
    Citation: Allergy, Asthma & Clinical Immunology 2020 16:70
    Content type: Letter to the editor Published on:

  37. Substantial experimental studies suggest a role for helminthes infections in the pathogenesis of allergies, but epidemiologic data have been inconsistent. Unlike to asthma, the association between helminthes i...

    Authors: Iraj Mohammadzadeh, Sorena Darvish, Seyed Mohammad Riahi, Solmaz Alizadeh Moghaddam, Mohammad Pournasrollah, Mousa Mohammadnia-Afrozi and Ali Rostami
    Citation: Allergy, Asthma & Clinical Immunology 2020 16:69
    Content type: Research Published on:

  38. Adherence to asthma treatment among children is usually poor. We sought to explore whether electronic adherence monitoring combined with weekly feedback regarding adherence along with a reminder to use inhaled...

    Authors: Jiande Chen, Juan Xu, Liebin Zhao, Jing Zhang, Yong Yin and Fen Zhang
    Citation: Allergy, Asthma & Clinical Immunology 2020 16:68
    Content type: Research Published on:

  39. Human microbiota plays a fundamental role in modulating the immune response. Western environment and lifestyle are envisaged to alter the human microbiota with a new microbiome profile established in Chinese i...

    Authors: Jing Guo, Xiaoping Zhang, Aarti Saiganesh, Christopher Peacock, Shu Chen, Gary A. Dykes, Belinda J. Hales, Peter N. Le Souëf and Guicheng Zhang
    Citation: Allergy, Asthma & Clinical Immunology 2020 16:67
    Content type: Research Published on:

  40. Asthma is a disease characterised by hyper responsiveness and bronchoconstriction of airways, and is a major health burden globally. A dysfunction of the oxidant-antioxidant balance, termed oxidative stress, h...

    Authors: Yenuli Fernando, Pujitha Wickramasinghe, Udani De Silva, Malintha Alahakoon, K. W. D. A. Anuradha and Shiroma Handunnetti
    Citation: Allergy, Asthma & Clinical Immunology 2020 16:66
    Content type: Research Published on:

  41. Loss-of-function (LOF) mutations in signal transducer and activator of transcription 3 (STAT3) is one of the causes of STAT3 hyperimmunoglobulin E (IgE) syndrome (STAT3-HIES), while gain-of-function (GOF) muta...

    Authors: Li Lin, Ying Wang, Bijun Sun, Luyao Liu, Wenjing Ying, Wenjie Wang, Qinhua Zhou, Jia Hou, Haili Yao, Liyuan Hu, Jinqiao Sun and Xiaochuan Wang
    Citation: Allergy, Asthma & Clinical Immunology 2020 16:65
    Content type: Research Published on:

  42. Peanut allergy affects 3% of Australian children and has a higher risk of anaphylaxis than most food allergies. Predicting who is likely to develop anaphylaxis is still an inexact science. The fraction of exha...

    Authors: Elizabeth Percival, Rani Bhatia, Kahn Preece, Mark McEvoy, Adam Collison and Joerg Mattes
    Citation: Allergy, Asthma & Clinical Immunology 2020 16:64
    Content type: Research Published on:

  43. Although the diagnosis and management of chronic spontaneous urticaria (CSU) is well documented in the literature, some aspects of the disease remain unclear. We aimed to further describe the natural history, ...

    Authors: Peter Stepaniuk, Manstein Kan and Amin Kanani
    Citation: Allergy, Asthma & Clinical Immunology 2020 16:63
    Content type: Research Published on:

  44. Vitamin D deficiency or insufficiency, has been associated with atopy and lack of asthma control. Our objective was to investigate associations between variants in genes of vitamin D pathway with serum levels ...

    Authors: Alana Alcântara Galvão, Flávia de Araújo Sena, Emília Maria Medeiros de Andrade Belitardo, Maria Borges Rabelo de Santana, Gustavo Nunes de Oliveira Costa, Álvaro Augusto Cruz, Maurício Lima Barreto, Ryan dos Santos Costa, Neuza Maria Alcantara-Neves and Camila Alexandrina Figueiredo
    Citation: Allergy, Asthma & Clinical Immunology 2020 16:62
    Content type: Research Published on:

  45. The differentiation of CD4+ lymphocytes Th17/regulatory T cells (Treg) and indoleamine 2,3-dioxygenase (IDO) is associated with the pathogenesis of allergic asthma. Basic research has shown that IDO is likely ...

    Authors: Ying Hu, Zhiqiang Chen, Jing Zeng, Shouyan Zheng, Liujuan Sun, Li Zhu and Wei Liao
    Citation: Allergy, Asthma & Clinical Immunology 2020 16:61
    Content type: Research Published on:

  46. Dupilumab is a receptor antagonist binding to the alpha subunit of the interleukin-4 receptor. Through binding to it, dupilumab inhibits signaling of both IL-4 and IL-13, the representative Th2 biomarkers. Rec...

    Authors: Dong Hyek Jang, Jae In Lee, Joo Yoon Bae, Hye Jung Jung, Mi Yeon Park and Jiyoung Ahn
    Citation: Allergy, Asthma & Clinical Immunology 2020 16:60
    Content type: Case report Published on:

  47. Mycobacterium vaccae nebulization imparted protective effect against allergic asthma in a mouse model. The TGF-β/Smad signal transduction pathway plays an important role in allergic bronchial asthma. However, the...

    Authors: Xiao-hong Jiang, Chao-qian Li, Guang-yi Feng, Ming-jie Luo and Qi-xiang Sun
    Citation: Allergy, Asthma & Clinical Immunology 2020 16:59
    Content type: Research Published on:

  48. The prevalence of allergic rhinitis (AR), an environment- and lifestyle-dependent condition, has been constantly increasing in Korea. Although the environment and lifestyle of the Korean people have recently u...

    Authors: Ji Heui Kim, Shin Ae Kim, Ja Yoon Ku, Won Ki Cho and Chol Ho Shin
    Citation: Allergy, Asthma & Clinical Immunology 2020 16:58
    Content type: Research Published on:

  49. Current recommendations for the management of penicillin allergy are to perform penicillin skin testing (PST) with penicilloyl-polylysine (PPL) and benzylpenicillin (BP) prior to drug challenge with amoxicilli...

    Authors: Roxane Labrosse, Louis Paradis, Kathryn Samaan, Jonathan Lacombe-Barrios, Jean Paradis, Philippe Bégin and Anne Des Roches
    Citation: Allergy, Asthma & Clinical Immunology 2020 16:57
    Content type: Letter to the editor Published on:

  50. Allergic bronchopulmonary aspergillosis (ABPA) is a severe hypersensitivity reaction to aspergillus species colonizing the airways of patients with asthma or cystic fibrosis. Biologics including anti-IgE and a...

    Authors: Carlo Mümmler, Bernd Kemmerich, Jürgen Behr, Nikolaus Kneidinger and Katrin Milger
    Citation: Allergy, Asthma & Clinical Immunology 2020 16:55
    Content type: Case report Published on:

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