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  1. Canada has high immunoglobulin (IG) product utilization, raising concerns about appropriate utilization, cost and risk of shortages. Currently, there is no national set of standardized IG guidelines, and consi...

    Authors: Megan Harmon, Kiarash Riazi, Jeannie Callum, Donald M. Arnold, Rebecca Barty, Davinder Sidhu, Nancy M. Heddle, Laurie MacLeod and Na Li
    Citation: Allergy, Asthma & Clinical Immunology 2023 19:85
    Content type: Review Published on:

  2. Idiopathic Anaphylaxis (IA) is the most common anaphylactic syndrome in adults. Mental health problems associated with IA are not well recognised. We aimed to assess if patients diagnosed with IA were more lik...

    Authors: Logan S Gardner, Zihao Tan, David Brown, David Gillis, James G. Scott and Roger Prentice
    Citation: Allergy, Asthma & Clinical Immunology 2023 19:84
    Content type: Research Published on:

  3. To investigate the role of combined impulse oscillometry (IOS) and fractional exhaled nitric oxide (FeNO) in the diagnosis of cough variant asthma (CVA) in preschool children.

    Authors: Ying Hu, Shouyan Zheng, Zhiqiang Chen, Dan Yu, Tianxia Lai, Yao Chen and Wei Liao
    Citation: Allergy, Asthma & Clinical Immunology 2023 19:83
    Content type: Research Published on:

  4. Anaphylaxis is an acute, potentially life-threatening allergic reaction that typically occurs after exposure to a trigger, while idiopathic anaphylaxis (IA) occurs in the absence of a trigger. Acute management...

    Authors: Elizabeth Pepper and Luke Pittman
    Citation: Allergy, Asthma & Clinical Immunology 2023 19:82
    Content type: Case report Published on:

  6. The prevalence of eosinophilic asthma in Lebanon, one of the most severe phenotypes among severe asthma, is not known. This study aimed at determining the prevalence of the eosinophilic phenotype defined as an...

    Authors: Wajdi Abi Saleh, Zuhair Alameh, Zeina Aoun Bacha, Joudy Bahous, Pierre Bou Khalil, Zahia Chahine, Hassan Chami, Georges Dabar, Hassan Dheiny, Alfred Dib, Dany farhat, Carla Irani, Georges Juvelekian, Nadim Kanj, Bassam Mansour, Moussa Riachi…
    Citation: Allergy, Asthma & Clinical Immunology 2023 19:80
    Content type: Research Published on:

  7. Interleukin (IL)-36 family cytokines have received increasing attention, especially in the fields of inflammation and immunity research. However, whether IL-36 family cytokine levels are correlated with the re...

    Authors: Jia Gu, Gang Qin, Liang Jiang, Wei Xu, Yuanyuan Wang, Jiangxue Liao, Hongzhu Pan and Zhuoping Liang
    Citation: Allergy, Asthma & Clinical Immunology 2023 19:79
    Content type: Research Published on:

  9. Autophagy protein 5 (ATG5) regulates airway epithelial cell autophagy, immune response, and inflammation, which is involved in asthma progression. This study aimed to evaluate ATG5 levels and its clinical role...

    Authors: Changjiang Ke and Sheng Xie
    Citation: Allergy, Asthma & Clinical Immunology 2023 19:77
    Content type: Research Published on:

  10. Respiratory conditions, such as asthma, are infrequently associated with auto-inflammatory diseases. We describe five patients with uncontrolled respiratory symptoms that were seen at St. Joesph’s Healthcare i...

    Authors: Bashayr M. Alotaibi, Raquel Lopez Rodriguez, Carmen Venegas Garrido, Lucia Gonzalez Bravo, Nader Khalidi and Parameswaran Nair
    Citation: Allergy, Asthma & Clinical Immunology 2023 19:76
    Content type: Case report Published on:

  11. Immunoglobulin A deficiency (IgAD) is a common disease with an unknown genetic defect, characterized by the decreased or absent IgA with other isotypes normal, normal subclasses, and specific antibodies. Patie...

    Authors: Ahmad Vosughimotlagh, Seyed Erfan Rasouli, Hosein Rafiemanesh, Molood Safarirad, Niusha Sharifinejad, Atossa Madanipour, Maria Marluce Dos Santos Vilela, Edyta Heropolitańska-Pliszka and Gholamreza Azizi
    Citation: Allergy, Asthma & Clinical Immunology 2023 19:75
    Content type: Review Published on:

  12. The market share of foods carrying labels suggesting absence of animal ingredients has significantly increased in recent years. The purpose of this study was to document the purchasing behaviour of egg- or mil...

    Authors: Silvia Dominguez, Jérémie Théolier, Kamila Lizée, Beatrice Povolo, Jennifer Gerdts and Samuel B. Godefroy
    Citation: Allergy, Asthma & Clinical Immunology 2023 19:74
    Content type: Short report Published on:

  13. Asthma is a chronic airway inflammatory disease that affects millions of Canadians and often contributes to higher levels of anxiety among patients. Since the coronavirus disease 2019 (COVID-19) pandemic was a...

    Authors: Sophia Linton, Kayley Xu, Lubnaa Hossenbaccus, Hannah Botting, Sarah Garvey, Adam Sunavsky, Lisa M. Steacy, Dean A. Tripp and Anne K. Ellis
    Citation: Allergy, Asthma & Clinical Immunology 2023 19:73
    Content type: Research Published on:

  14. The rate of cytomegalovirus (CMV) retinitis is increasing, likely secondary to aggressive immunosuppressive regimens for a variety of diseases. Transplant and rheumatological literature show growing evidence s...

    Authors: Prem N. Patel, Ahmed M. Alkaliby, Mitul C. Mehta and Angeline L. Wang
    Citation: Allergy, Asthma & Clinical Immunology 2023 19:72
    Content type: Case report Published on:

  15. Real world data on the response to the SARS-CoV-2 vaccine in patients with immunomediated diseases (IMIDs) treated with immunesuppressants is of great interest because vaccine response may be impaired. The mai...

    Authors: Chamaida Plasencia-Rodríguez, Ana Martínez-Feito, Marta Hernández, Lucia Del Pino-Molina, Marta Novella-Navarro, Yolanda Serrano, Miguel González-Muñoz, Diana Peiteado, Gema Bonilla, Irene Monjo, Laura Nuño, Carolina Tornero, Eduardo López-Granados, Alejandro Balsa and Pilar Nozal
    Citation: Allergy, Asthma & Clinical Immunology 2023 19:71
    Content type: Research Published on:

  16. Allergy to chicken egg protein is a common form of food allergy. The most common clinical presentation includes gastrointestinal, skin, and respiratory symptoms. Differential diagnosis, including provocative t...

    Authors: E. Krzych-Fałta, O. Wojas, P. Samel-Kowalik, B. Samoliński, A. Sybilski and S. Białek
    Citation: Allergy, Asthma & Clinical Immunology 2023 19:70
    Content type: Case report Published on:

  17. Inborn errors of immunity (IEIs) are considered significant challenges for children with IEIs, their families, and their medical providers. Infections are the most common complication of IEIs and children can ...

    Authors: Saad Alhumaid, Koblan M. Al Mutared, Zainab Al Alawi, Zainah Sabr, Ola Alkhars, Muneera Alabdulqader, Nourah Al Dossary, Fatemah M. ALShakhs, Rabab Abbas Majzoub, Yousef Hassan Alalawi, Khalid Al Noaim, Abdulrahman A. Alnaim, Mohammed A. Al Ghamdi, Abdulaziz A. Alahmari, Sawsan Sami Albattat, Yasin S. Almubarak…
    Citation: Allergy, Asthma & Clinical Immunology 2023 19:69
    Content type: Research Published on:

  18. Wiskott-Aldrich syndrome (WAS) is an X-linked primary immunodeficiency caused by mutations in the WAS gene that leads to increased susceptibility to infections, thrombocytopenia, eczema, malignancies, and autoimm...

    Authors: Vivien X. Xie, Wilson File, Christina Wiedl, Brant R. Ward, Blachy Dávila Saldaña, Michael D. Keller and Alexandra B. Kornbluh
    Citation: Allergy, Asthma & Clinical Immunology 2023 19:68
    Content type: Case report Published on:

  19. Aspirin-exacerbated respiratory disease (AERD) and IgG4-related disease (IgG4RD) share a common pathway of Th2-mediated immune mechanism; there have been several cases of IgG4RD developed in patients with asth...

    Authors: Hyun-Seob Jeon, Jae-Hyuk Jang, Youngsoo Lee and Hae-Sim Park
    Citation: Allergy, Asthma & Clinical Immunology 2023 19:67
    Content type: Case report Published on:

  20. Treatment of cystic fibrosis (CF) has been revolutionized by the use of cystic fibrosis transmembrane conductance regulator (CFTR) protein modulators such as elexacaftor/tezacaftor/ivacaftor (ETI) triple thera...

    Authors: A. M. Mehta, I. Lee, G. Li, M. K. Jones, L. Hanson, K. Lonabaugh, R. List, L. Borish and D. P. Albon
    Citation: Allergy, Asthma & Clinical Immunology 2023 19:66
    Content type: Research Published on:

  21. Approximately 6–7% of Canadian children have food allergy. These families face substantial burdens due to the additional costs incurred purchasing allergy-friendly products necessary for management compared to...

    Authors: Manvir Bhamra, Zoe Harbottle, Michael A Golding, Moshe Ben-Shoshan, Leslie E Roos, Elissa M Abrams, Sara J Penner, Jo-Anne St-Vincent and Jennifer LP Protudjer
    Citation: Allergy, Asthma & Clinical Immunology 2023 19:65
    Content type: Research Published on:

  22. Recurring therapy resistant hives, accompanied by IgM-gammopathy, fever and joint pain can indicate Schnitzler syndrome, a rare autoimmune disorder. There is currently no approved treatment, but complete remis...

    Authors: Viktoria Puxkandl, Antonia Currie, Wolfram Hoetzenecker and Sabine Altrichter
    Citation: Allergy, Asthma & Clinical Immunology 2023 19:64
    Content type: Case report Published on:

  24. Food allergy affects 7-8% of children worldwide. Teachers supervise children in school, where most children spend their day. Yet, teachers have variable food allergy-related knowledge.

    Authors: Mae Jhelene L. Santos, Kaitlyn Merrill, Natalie Riediger, Elissa M. Abrams, Nathalie Piquemal, Elinor Simons and Jennifer L.P. Protudjer
    Citation: Allergy, Asthma & Clinical Immunology 2023 19:62
    Content type: Research Published on:

  27. Secukinumab has been approved by the U.S. FDA and the European Medicines Agency for the treatment of moderate-to-severe plaque psoriasis and psoriatic arthritis with the documented adverse effects. Here we rep...

    Authors: Qingqing Yang, Jiajie Lyu, Yu Gui, Shuling Yu, Jiajie Chen, Haoxue Zhang and Shengxiu Liu
    Citation: Allergy, Asthma & Clinical Immunology 2023 19:59
    Content type: Case report Published on:

  30. “Epidemiology of comorbidities and their association with asthma control” (Tomisa, G., Horváth, A., Sánta, B. et al. Epidemiology of comorbidities and their association with asthma control. Allergy Asthma Clin Im...

    Authors: Diego M. Conti, Peter W. Hellings, Zuzana Diamant, Leif Bjermer, Milos Jesenak, Vibeke Backer, Wytske Fokkens, Susanne Lau, Elizabeth Van Staeyen and Glenis K. Scadding
    Citation: Allergy, Asthma & Clinical Immunology 2023 19:56
    Content type: Letter to the editor Published on:

  31. Helminth/tuberculosis (TB)-coinfection can reduce cell-mediated immunity against Mycobacterium tuberculosis (Mtb) and increase disease severity, although the effects are highly helminth species dependent. Mtb hav...

    Authors: Giggil Pushpamithran, Camilla Skoglund, Fanny Olsson, Melissa Méndez-Aranda, Thomas Schön, Mårten Segelmark, Olle Stendahl, Robert H. Gilman and Robert Blomgran
    Citation: Allergy, Asthma & Clinical Immunology 2023 19:55
    Content type: Research Published on:

  32. Authors: Paul K. Keith, Juthaporn Cowan, Amin Kanani, Harold Kim, Gina Lacuesta, Jason K. Lee, Jie Chen, Michelle Park and André Gladiator
    Citation: Allergy, Asthma & Clinical Immunology 2023 19:54
    Content type: Correction Published on:

    The original article was published in Allergy, Asthma & Clinical Immunology 2022 18:70

  34. Allergic disease is on the rise. Waitlists for specialists are long, and many referred patients have already received prior allergic assessment, either by a certified Allergist, Primary Care Provider, or other...

    Authors: Adam P. Sage, Elliot James, Megan Burke, Edmond S. Chan and Tiffany Wong
    Citation: Allergy, Asthma & Clinical Immunology 2023 19:52
    Content type: Research Published on:

  35. Severe Congenital Neutropenia type 4 (SCN4), is a rare autosomal recessive condition, due to mutations in the G6PC3 gene. The phenotype comprises neutropenia of variable severity and accompanying anomalies.

    Authors: Negar Moradian, Samaneh Zoghi, Elham Rayzan, Simin Seyedpour, Raul Jimenez Heredia, Kaan Boztug and Nima Rezaei
    Citation: Allergy, Asthma & Clinical Immunology 2023 19:51
    Content type: Case report Published on:

  37. The effects of nicotine and cigarette smoke in many diseases, notably COVID-19 infection, are being debated more frequently. The current basic data for COVID-19 is increasing and indicating the higher risk of ...

    Authors: Zahra Salehi, Bibi Fatemeh Nobakht Motlagh Ghoochani, Yazdan Hasani Nourian, Sadegh Azimzadeh Jamalkandi and Mostafa Ghanei
    Citation: Allergy, Asthma & Clinical Immunology 2023 19:49
    Content type: Review Published on:

  38. Hereditary angioedema (HAE) is a rare disease characterized by unpredictable, recurring subcutaneous or submucosal swelling. Without effective therapy, HAE can negatively impact patients’ quality of life. Mana...

    Authors: Joan Mendivil, Maral DerSarkissian, Aleena Banerji, Lavanya Diwakar, Constance H. Katelaris, Paul K. Keith, Harold Kim, Gina Lacuesta, Markus Magerl, Charlotte Slade, William B. Smith, Zia Choudhry, Angela Simon, Sujata P. Sarda and Paula J. Busse
    Citation: Allergy, Asthma & Clinical Immunology 2023 19:48
    Content type: Research Published on:

  39. Children with food allergy, and their families experience substantial burdens because of efforts necessary to minimize the risk of anaphylaxis. To this end, peer-to-peer education is paramount. Food Allergy Ca...

    Authors: Ranjit Dhanjal, Kyle Dine, Jennifer Gerdts, Kaitlyn Merrill, Tara Lynn M Frykas and Jennifer LP Protudjer
    Citation: Allergy, Asthma & Clinical Immunology 2023 19:47
    Content type: Research Published on:

  40. To validate case definitions for eczema using primary care Electronic Medical Record (EMR) data from the Canadian Primary Care Sentential Surveillance Network (CPCSSN).

    Authors: Hannah Stirton, Leanne Kosowan, Elissa M Abrams, Jennifer LP Protudjer, John Queenan and Alexander Singer
    Citation: Allergy, Asthma & Clinical Immunology 2023 19:46
    Content type: Research Published on:

  41. Pediatric food allergy is associated with excess familial food costs compared to families without allergy. Since the start of the COVID-19 pandemic, food prices have increased substantially.

    Authors: Michael A. Golding, Leslie E. Roos, Elissa M. Abrams, Jennifer D. Gerdts and Jennifer L. P. Protudjer
    Citation: Allergy, Asthma & Clinical Immunology 2023 19:45
    Content type: Letter to the editor Published on:

  42. Primary antibody deficiencies (PAD) are characterized by a heterogeneous clinical presentation and low prevalence, contributing to a median diagnostic delay of 3–10 years. This increases the risk of morbidity ...

    Authors: Marianne A. Messelink, Roos M. Berbers, Joris M. van Montfrans, Pauline M. Ellerbroek, André Gladiator, Paco M. J. Welsing and Helen Leavis
    Citation: Allergy, Asthma & Clinical Immunology 2023 19:44
    Content type: Research Published on:

  44. Hereditary angioedema (HAE), which is caused by C1-inhibitor (C1-INH) deficiency or dysfunction, is a rare and potentially life-threatening disease. In patients with HAE, excess production of bradykinin causes...

    Authors: Daisuke Honda, Isao Ohsawa, Masashi Aizawa, Yasuhiko Tomino and Katsuhiko Asanuma
    Citation: Allergy, Asthma & Clinical Immunology 2023 19:42
    Content type: Case report Published on:

  45. Allergic rhinitis (AR) is a chronic disease with high prevalence. There are currently many treatments available. However, despite an often good therapeutic response, many patients still report impairment in qu...

    Authors: Eric Hjalmarsson, Marianne Petro, Susanna Kumlien Georén, Ola Winqvist and Lars Olaf Cardell
    Citation: Allergy, Asthma & Clinical Immunology 2023 19:41
    Content type: Research Published on:

  46. The mainstay of treatment for eosinophilic granulomatosis with polyangiitis (EGPA) is systemic corticosteroid therapy; some patients also receive intravenous immunoglobulins, other immunosuppressive agents, an...

    Authors: Nami Masumoto, Chiyako Oshikata, Ryo Nakadegawa, Yuto Motobayashi, Reeko Osada, Saki Manabe, Takeshi Kaneko and Naomi Tsurikisawa
    Citation: Allergy, Asthma & Clinical Immunology 2023 19:40
    Content type: Research Published on:

  47. IL-6 is a pleotropic cytokine that acts as a pro-inflammatory mediator and acute-phase response inducer, but has also been reported to possess anti-inflammatory properties. The objective of this study was to a...

    Authors: Ruilin Pan, Shougang Kuai, Qingqing Li, Xuming Zhu, Tingting Wang and Yubao Cui
    Citation: Allergy, Asthma & Clinical Immunology 2023 19:39
    Content type: Review Published on:

  48. The Champlain BASE™ and Ontario eConsult services are virtual platforms that serve to facilitate contact between primary care providers and specialists across Ontario, relaying patient-specific questions to re...

    Authors: Graham Walter, Samira Jeimy, Clare Liddy, Sheena Guglani, Anne K. Ellis, Amy Blair, Hazar Kobayaa, Zave Chad and Erin Keely
    Citation: Allergy, Asthma & Clinical Immunology 2023 19:38
    Content type: Research Published on:

  49. COVID-19 disproportionately affects those with preexisting conditions, but little research has determined whether those with chronic diseases view the pandemic itself differently - and whether there are differ...

    Authors: Brianna A. Smith, Emily E. Ricotta, Jennifer L. Kwan and Nicholas G. Evans
    Citation: Allergy, Asthma & Clinical Immunology 2023 19:37
    Content type: Research Published on:

  50. Primary immunodeficiency disorders (PID) are rare disorders with heterogeneous manifestations, overlapping with other diseases such as autoimmunity, malignancy, and infections. This makes the diagnosis very ch...

    Authors: Sabiha Anis, Aiysha Abid, Sadaf Aba Umer Kodwavwala, Sabahat Sarfaraz, Samina Junejo, Saba Shahid, Sajid Sultan and Adibul Hasan Rizvi
    Citation: Allergy, Asthma & Clinical Immunology 2023 19:36
    Content type: Case report Published on:

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