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  1. Allergic disease is on the rise. Waitlists for specialists are long, and many referred patients have already received prior allergic assessment, either by a certified Allergist, Primary Care Provider, or other...

    Authors: Adam P. Sage, Elliot James, Megan Burke, Edmond S. Chan and Tiffany Wong
    Citation: Allergy, Asthma & Clinical Immunology 2023 19:52
  2. Severe Congenital Neutropenia type 4 (SCN4), is a rare autosomal recessive condition, due to mutations in the G6PC3 gene. The phenotype comprises neutropenia of variable severity and accompanying anomalies.

    Authors: Negar Moradian, Samaneh Zoghi, Elham Rayzan, Simin Seyedpour, Raul Jimenez Heredia, Kaan Boztug and Nima Rezaei
    Citation: Allergy, Asthma & Clinical Immunology 2023 19:51
  3. The effects of nicotine and cigarette smoke in many diseases, notably COVID-19 infection, are being debated more frequently. The current basic data for COVID-19 is increasing and indicating the higher risk of ...

    Authors: Zahra Salehi, Bibi Fatemeh Nobakht Motlagh Ghoochani, Yazdan Hasani Nourian, Sadegh Azimzadeh Jamalkandi and Mostafa Ghanei
    Citation: Allergy, Asthma & Clinical Immunology 2023 19:49
  4. Hereditary angioedema (HAE) is a rare disease characterized by unpredictable, recurring subcutaneous or submucosal swelling. Without effective therapy, HAE can negatively impact patients’ quality of life. Mana...

    Authors: Joan Mendivil, Maral DerSarkissian, Aleena Banerji, Lavanya Diwakar, Constance H. Katelaris, Paul K. Keith, Harold Kim, Gina Lacuesta, Markus Magerl, Charlotte Slade, William B. Smith, Zia Choudhry, Angela Simon, Sujata P. Sarda and Paula J. Busse
    Citation: Allergy, Asthma & Clinical Immunology 2023 19:48
  5. Children with food allergy, and their families experience substantial burdens because of efforts necessary to minimize the risk of anaphylaxis. To this end, peer-to-peer education is paramount. Food Allergy Ca...

    Authors: Ranjit Dhanjal, Kyle Dine, Jennifer Gerdts, Kaitlyn Merrill, Tara Lynn M Frykas and Jennifer LP Protudjer
    Citation: Allergy, Asthma & Clinical Immunology 2023 19:47
  6. To validate case definitions for eczema using primary care Electronic Medical Record (EMR) data from the Canadian Primary Care Sentential Surveillance Network (CPCSSN).

    Authors: Hannah Stirton, Leanne Kosowan, Elissa M Abrams, Jennifer LP Protudjer, John Queenan and Alexander Singer
    Citation: Allergy, Asthma & Clinical Immunology 2023 19:46
  7. Pediatric food allergy is associated with excess familial food costs compared to families without allergy. Since the start of the COVID-19 pandemic, food prices have increased substantially.

    Authors: Michael A. Golding, Leslie E. Roos, Elissa M. Abrams, Jennifer D. Gerdts and Jennifer L. P. Protudjer
    Citation: Allergy, Asthma & Clinical Immunology 2023 19:45
  8. Primary antibody deficiencies (PAD) are characterized by a heterogeneous clinical presentation and low prevalence, contributing to a median diagnostic delay of 3–10 years. This increases the risk of morbidity ...

    Authors: Marianne A. Messelink, Roos M. Berbers, Joris M. van Montfrans, Pauline M. Ellerbroek, André Gladiator, Paco M. J. Welsing and Helen Leavis
    Citation: Allergy, Asthma & Clinical Immunology 2023 19:44
  9. Hereditary angioedema (HAE), which is caused by C1-inhibitor (C1-INH) deficiency or dysfunction, is a rare and potentially life-threatening disease. In patients with HAE, excess production of bradykinin causes...

    Authors: Daisuke Honda, Isao Ohsawa, Masashi Aizawa, Yasuhiko Tomino and Katsuhiko Asanuma
    Citation: Allergy, Asthma & Clinical Immunology 2023 19:42
  10. Allergic rhinitis (AR) is a chronic disease with high prevalence. There are currently many treatments available. However, despite an often good therapeutic response, many patients still report impairment in qu...

    Authors: Eric Hjalmarsson, Marianne Petro, Susanna Kumlien Georén, Ola Winqvist and Lars Olaf Cardell
    Citation: Allergy, Asthma & Clinical Immunology 2023 19:41
  11. The mainstay of treatment for eosinophilic granulomatosis with polyangiitis (EGPA) is systemic corticosteroid therapy; some patients also receive intravenous immunoglobulins, other immunosuppressive agents, an...

    Authors: Nami Masumoto, Chiyako Oshikata, Ryo Nakadegawa, Yuto Motobayashi, Reeko Osada, Saki Manabe, Takeshi Kaneko and Naomi Tsurikisawa
    Citation: Allergy, Asthma & Clinical Immunology 2023 19:40
  12. IL-6 is a pleotropic cytokine that acts as a pro-inflammatory mediator and acute-phase response inducer, but has also been reported to possess anti-inflammatory properties. The objective of this study was to a...

    Authors: Ruilin Pan, Shougang Kuai, Qingqing Li, Xuming Zhu, Tingting Wang and Yubao Cui
    Citation: Allergy, Asthma & Clinical Immunology 2023 19:39
  13. The Champlain BASE™ and Ontario eConsult services are virtual platforms that serve to facilitate contact between primary care providers and specialists across Ontario, relaying patient-specific questions to re...

    Authors: Graham Walter, Samira Jeimy, Clare Liddy, Sheena Guglani, Anne K. Ellis, Amy Blair, Hazar Kobayaa, Zave Chad and Erin Keely
    Citation: Allergy, Asthma & Clinical Immunology 2023 19:38
  14. COVID-19 disproportionately affects those with preexisting conditions, but little research has determined whether those with chronic diseases view the pandemic itself differently - and whether there are differ...

    Authors: Brianna A. Smith, Emily E. Ricotta, Jennifer L. Kwan and Nicholas G. Evans
    Citation: Allergy, Asthma & Clinical Immunology 2023 19:37
  15. Primary immunodeficiency disorders (PID) are rare disorders with heterogeneous manifestations, overlapping with other diseases such as autoimmunity, malignancy, and infections. This makes the diagnosis very ch...

    Authors: Sabiha Anis, Aiysha Abid, Sadaf Aba Umer Kodwavwala, Sabahat Sarfaraz, Samina Junejo, Saba Shahid, Sajid Sultan and Adibul Hasan Rizvi
    Citation: Allergy, Asthma & Clinical Immunology 2023 19:36
  16. Allergic asthma occurs worldwide and is particularly prevalent in westernized countries characterized by chronic airway inflammation resulting in airway hyperresponsiveness. The house dust mites (HDM) including D...

    Authors: Jaw-Ji Tsai, Chung-Yang Yen, Chun-Hsien Hsu, Sheng-Jie Yu, Chao-Hsien Chen and En-Chih Liao
    Citation: Allergy, Asthma & Clinical Immunology 2023 19:35
  17. Scientific evidence on patients with multimorbid type 2 asthma and chronic rhinosinusitis with nasal polyps (CRSwNP) from a united airways disease (UAD) perspective remains scarce, despite the frequent coexist...

    Authors: Marina Blanco-Aparicio, Javier Domínguez-Ortega, Carolina Cisneros, Carlos Colás, Francisco Casas, Alfonso del Cuvillo, Isam Alobid, Santiago Quirce and Joaquim Mullol
    Citation: Allergy, Asthma & Clinical Immunology 2023 19:34
  18. Job’s syndrome, or autosomal dominant hyperimmunoglobulin E syndrome (AD-HIES, STAT3-Dominant Negative), is a rare inborn error of immunity (IEI) with multi-organ involvement and long-life post-infective damag...

    Authors: Maria Carrabba, Rosa Maria Dellepiane, Manuela Cortesi, Lucia Augusta Baselli, Annarosa Soresina, Emilia Cirillo, Giuliana Giardino, Francesca Conti, Laura Dotta, Andrea Finocchi, Caterina Cancrini, Cinzia Milito, Lucia Pacillo, Bianca Laura Cinicola, Fausto Cossu, Rita Consolini…
    Citation: Allergy, Asthma & Clinical Immunology 2023 19:32
  19. With ongoing COVID-19 vaccination schedules and the popularity of cosmetic fillers, it is important to examine and record associated adverse reactions to a more general audience of health care professionals. C...

    Authors: Safaa Azzouz, Derek Lanoue, Katéri Champagne and Genevieve Genest
    Citation: Allergy, Asthma & Clinical Immunology 2023 19:31
  20. Inaccurate penicillin allergy labels lead to inappropriate antibiotic prescriptions and harmful patient consequences. System-wide efforts are needed to remove incorrect penicillin allergy labels, but more heal...

    Authors: Sujen Saravanabavan, Amneet Aulakh, Josh Douglas, Chelsea Elwood, Stephanie Erdle, Jennifer Grant, Kristopher T. Kang, Natasha Kwan, Katie Lacaria, Tim T. Y. Lau, Colin Lee, Victor Leung, Yu-Chen Lin, Allison Mah, Anne Nguyen, Vanessa Paquette…
    Citation: Allergy, Asthma & Clinical Immunology 2023 19:30
  21. Caspase-8 is a molecule in the FAS pathway that initiates apoptosis. One of the rarest autoimmune lymphoproliferative syndromes is caspase-8 deficiency. Immunodeficiency, splenomegaly, and lymphadenopathy are ...

    Authors: Narges Bazgir, Azin Tahvildari, Zahra Chavoshzade, Mahnaz Jamee, Zahra Golchehre, Abdollah Karimi, Naghi Dara, Mazdak Fallahi, Mohammad Keramatipour, Arezou Karamzade and Samin Sharafian
    Citation: Allergy, Asthma & Clinical Immunology 2023 19:29
  22. Hereditary angioedema (HAE) is a rare and life-threatening inborn error of immunity. HAE is mostly caused by pathogenic variations in the serine protease inhibitor gene 1 (SERPING1), leading to deficient or dysfu...

    Authors: Adine Kanepa, Inga Nartisa, Dmitrijs Rots, Linda Gailite, Henriette Farkas and Natalja Kurjane
    Citation: Allergy, Asthma & Clinical Immunology 2023 19:28
  23. Nocardiosis is a disease that mainly affects immunocompromised patients. Inhaled corticosteroids (ICS) are standard of care for asthma. This treatment can induce respiratory infections but no case of bronchiol...

    Authors: Estelle Cascarano, Murielle Frappa, Bruno Degano, Isabelle Pelloux, Christel Saint-Raymond and Hubert Gheerbrant
    Citation: Allergy, Asthma & Clinical Immunology 2023 19:27
  24. In 2020, dupilumab became the first monoclonal antibody therapy to be approved by Health Canada for the treatment of chronic rhinosinusitis with nasal polyps (CRSwNP). The primary aim of this study was to char...

    Authors: Elysia Grose, Alyssa Y. Li and John M. Lee
    Citation: Allergy, Asthma & Clinical Immunology 2023 19:26
  25. The novel coronavirus disease of 2019 (COVID-19) pandemic has severely impacted the training of health care professional students because of concerns of potential asymptomatic transmission to colleagues and vu...

    Authors: Alyssa G. Burrows, Sophia Linton, Jenny Thiele, Prameet M. Sheth, Gerald A. Evans, Stephen Archer, Katharine M. Doliszny, Marcia Finlayson, Leslie Flynn, Yun Huang, Azim Kasmani, T. Hugh Guan, Allison Maier, Adrienne Hansen-Taugher, Kieran Moore, Anthony Sanfilippo…
    Citation: Allergy, Asthma & Clinical Immunology 2023 19:25
  26. Cases of food allergy after hematopoietic stem cell and solid organ transplantation in previously nonallergic transplant recipients were reported as transplant-acquired food allergy (TAFA), but information abo...

    Authors: Akiko Nakaoka, Takayasu Nomura, Kazuyoshi Ozeki, Tomotaka Suzuki, Shigeru Kusumoto, Shinsuke Iida and Shinji Saitoh
    Citation: Allergy, Asthma & Clinical Immunology 2023 19:24
  27. Selective IgA deficiency (SIgAD) is the most prevalent inborn errors of immunity with almost unknown etiology. This study aimed to investigate the clinical diagnostic and prognostic values of lymphocyte subset...

    Authors: Yasser Bagheri, Tannaz Moeini Shad, Shideh Namazi, Farzaneh Tofighi Zavareh, Gholamreza Azizi, Fereshteh Salami, Somayeh Sadani, Ali Hosseini, Mohsen Saeidi, Salar Pashangzadeh, Samaneh Delavari, Babak Mirminachi, Nima Rezaei, Hassan Abolhassani, Asghar Aghamohammadi and Reza Yazdani
    Citation: Allergy, Asthma & Clinical Immunology 2023 19:23
  28. Peanut allergy and its current management, involving peanut avoidance and use of rescue medication during instances of accidental exposure, are burdensome to patients and their caregivers and can be a source o...

    Authors: Katharina Blumchen, Andreas Kleinheinz, Ludger Klimek, Kirsten Beyer, Aikaterini Anagnostou, Christian Vogelberg, Sergejus Butovas, Robert Ryan, David Norval, Stefan Zeitler and George Du Toit
    Citation: Allergy, Asthma & Clinical Immunology 2023 19:21
  29. Subcutaneous immunotherapy (SCIT) is a well-validated and effective disease modification treatment for house dust mites (HDM)-induced allergic rhinitis (AR). Long-term post-treatment comparisons in children an...

    Authors: Lei Ren, Chengshuo Wang, Lin Xi, Yunbo Gao, Yuan Zhang and Luo Zhang
    Citation: Allergy, Asthma & Clinical Immunology 2023 19:20
  30. Previous studies have shown that CD134 (OX40) co-stimulation is involved in the pathogenesis of experimental autoimmune encephalomyelitis (EAE) models and the antigen is expressed within multiple sclerosis le...

    Authors: Mostafa Manian, Morteza Motallebnezhad, Reza Nedaeinia, Rasoul Salehi, Leila Khani, Gordon A. Ferns and Mir Hadi Jazayeri
    Citation: Allergy, Asthma & Clinical Immunology 2023 19:19
  31. Results of studies evaluating the relationship between asthma occurrence and early life antibiotic use have been conflicting. The aim of this study was to investigate the relationship between occurrence of ast...

    Authors: Hayat Bentouhami, Milcah Kahkelam Bungwa, Lidia Casas, Samuel Coenen and Joost Weyler
    Citation: Allergy, Asthma & Clinical Immunology 2023 19:18
  32. Penicillin allergy is a commonly listed medication allergy despite rare overall incidence. Many patients erroneously have this label, which has personal, health, and societal costs. Penicillin allergy delabell...

    Authors: Arian Ghassemian, Geetanjalee Sadi, Raymond Mak, Stephanie Erdle, Tiffany Wong and Samira Jeimy
    Citation: Allergy, Asthma & Clinical Immunology 2023 19:17
  33. The most frequent non-immediate reactions described with iodinated contrast media (ICM) are mild to moderate, however, some cases of patients with severe non-immediate reactions, such as drug eruption with eos...

    Authors: G. Zambrano Ibarra, B. Noguerado Mellado, P. Tornero Molina, C. Cuevas Bravo and P. Rojas Pérez-Esquerra
    Citation: Allergy, Asthma & Clinical Immunology 2023 19:16
  34. The Cystic Fibrosis Foundation Patient Registry (CFFPR) reports a high prevalence of asthma (34.6%) in people with Cystic Fibrosis (PwCF). While our current understanding of this relationship is limited, a typ...

    Authors: Dana Albon, Lijia Zhang, James Patrie, Marieke Jones, Z. Galvin Li, Emily Noonan and Larry Borish
    Citation: Allergy, Asthma & Clinical Immunology 2023 19:15
  35. DCLRE1C gene mutation leads to Artemis deficiency, a severe form of combined immunodeficiency (SCID). Impaired DNA repair and block in early adaptive immunity maturation results in T-B-NK+ immunodeficiency associ...

    Authors: Soodeh Ghadimi, Mahnaz Jamee, Hassan Abolhassani, Nima Parvaneh, Nima Rezaei, Samaneh Delavari, Mahnaz Sadeghi-Shabestari, Sedigheh Rafiei Tabatabaei, Alireza Fahimzad, Shahnaz Armin, Zahra Chavoshzadeh and Samin Sharafian
    Citation: Allergy, Asthma & Clinical Immunology 2023 19:13
  36. In Canada, severe asthma affects an estimated 5–10% of people with asthma and is associated with frequent exacerbations, poor symptom control and significant morbidity from the disease itself, as well as the h...

    Authors: K. Godbout, M. Bhutani, L. Connors, C. K. N. Chan, C. Connors, D. Dorscheid, G. Dyck, V. Foran, A. G. Kaplan, J. Reynolds and S. Waserman
    Citation: Allergy, Asthma & Clinical Immunology 2023 19:12
  37. Chronic obstructive pulmonary disease (COPD) affects up to 10% of Canadians. Patients with COPD may present with secondary humoral immunodeficiency as a result of chronic disease, poor nutrition or frequent co...

    Authors: Nami Shrestha Palikhe, Malcena Niven, Desi Fuhr, Tristan Sinnatamby, Brian H. Rowe, Mohit Bhutani, Michael K. Stickland and Harissios Vliagoftis
    Citation: Allergy, Asthma & Clinical Immunology 2023 19:10
  38. High-fidelity simulations based on real-life clinical scenarios have frequently been used to improve patient care, knowledge and teamwork in the acute care setting. Still, they are seldom included in the aller...

    Authors: Ana M. Copaescu, Francois Graham, Nathalie Nadon, Rémi Gagnon, Arnaud Robitaille, Mohamed Badawy, David Claveau, Anne Des Roches, Jean Paradis, Matthieu Vincent and Philippe Bégin
    Citation: Allergy, Asthma & Clinical Immunology 2023 19:9
  39. House dust mite (HDM) induces greater responses than other allergens during allergen bronchoprovocation (ABP) testing. The two standardized methods for reporting results of ABP tests are the maximal percent fa...

    Authors: Sarah-Marie Durr, Beth Davis, Gail Gauvreau and Donald Cockcroft
    Citation: Allergy, Asthma & Clinical Immunology 2023 19:8
  40. Allergy immunotherapy (AIT), in the form of subcutaneous immunotherapy (SCIT) with alum-precipitated aqueous extracts, SCIT with a modified ragweed pollen allergen tyrosine adsorbate (MRPATA; Pollinex®-R), or a s...

    Authors: Anne K. Ellis, Douglas P. Mack, Rémi Gagnon, Eva Hammerby and Sheena Gosain
    Citation: Allergy, Asthma & Clinical Immunology 2023 19:7
  41. The diagnosis of food allergy is based on a history of immediate allergic reaction following food ingestion, and skin prick test (SPT) demonstrating sensitization with commercial extracts (CE) or fresh food (F...

    Authors: Idit Lachover-Roth, Nadav Giorno, Tzipi Hornik-Lurie, Anat Cohen-Engler, Yossi Rosman, Keren Meir-Shafrir and Ronit Confino-Cohen
    Citation: Allergy, Asthma & Clinical Immunology 2023 19:6
  42. Oral food challenges (OFC) confer the highest sensitivity and specificity in diagnosis; however, uptake has been variable across clinical settings. Numerous barriers were identified in literature from inadequa...

    Authors: Ala El Baba, Samira Jeimy, Lianne Soller, Harold Kim, Philippe Begin and Edmond S. Chan
    Citation: Allergy, Asthma & Clinical Immunology 2023 19:5
  43. The immunological effect of allergen-specific immunotherapy is well documented, but few studies have examined the long-term effects of pollen subcutaneous immunotherapy (SCIT) on health-related quality of life...

    Authors: Helena Agenäs, Anna Lena Brorsson, Inger Kull and Anna Lindholm-Olinder
    Citation: Allergy, Asthma & Clinical Immunology 2023 19:4
  44. Viable knowledge translation (KT) strategies are increasingly sought to improve asthma diagnosis, particularly in primary care. Despite this understanding, practical KT tools to support primary care practition...

    Authors: Max Moloney, Geneviève Digby, Madison MacKinnon, Alison Morra, David Barber, John Queenan, Samir Gupta, Teresa To and M. Diane Lougheed
    Citation: Allergy, Asthma & Clinical Immunology 2023 19:3

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