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  1. Long non-coding RNAs (lncRNAs) have been extensively reported to play critical roles in the pathogenesis of various disease, especially in cancer. However, little is known about the role of lncRNAs in the path...

    Authors: Zhang Xude, Feng Shaojie, Guo Beibei, Liu Jingjing, Xu Donghua and Liu Fengxia
    Citation: Allergy, Asthma & Clinical Immunology 2022 18:101
    Content type: Research Published on:

  2. Sensitization to Ara h 2 has been proposed as a promising biological marker for the severity of peanut allergy and may reduce the need for oral food challenges. This study aimed to evaluate whether peanut oral...

    Authors: Iida Ojaniemi, Susanna Salmivesi, Antti Tikkakoski, Jussi Karjalainen, Lauri Lehtimäki and Rüdiger Schultz
    Citation: Allergy, Asthma & Clinical Immunology 2022 18:100
    Content type: Research Published on:

  3. Self-administered subcutaneous immunoglobulin G (SCIg) reduces nursing time and eliminates the need for treatment at ambulatory care clinics, as compared with clinic-based intravenously administered IgG (IVIg)...

    Authors: Bruce Ritchie, Karen J. B. Martins, Dat T. Tran, Heather Blain, Lawrence Richer and Scott W. Klarenbach
    Citation: Allergy, Asthma & Clinical Immunology 2022 18:99
    Content type: Research Published on:

  4. Risk factors for the pathogenesis of chronic rhinosinusitis (CRS) remain largely undetermined, which is likely due to the heterogeneity of the disease. White blood cell counts have been largely unexplored as a...

    Authors: Thanai Pongdee, Suzette J. Bielinski, Paul A. Decker, Hirohito Kita and Nicholas B. Larson
    Citation: Allergy, Asthma & Clinical Immunology 2022 18:98
    Content type: Research Published on:

  6. Mendelian susceptibility to mycobacterial disease (MSMD) is an uncommon disorder with increased susceptibility to less virulent mycobacteria including bacillus Calmette-Guérin (BCG). Fibrosing mediastinitis (FM) ...

    Authors: Niusha Sharifinejad, Seyed Alireza Mahdaviani, Shahrzad Fallah, Nasrin Khakbazan Fard, Alireza Norouzi, Mahnaz Jamee, Mahnaz Sadeghi-Shabestari, Majid Marjani, Mehran Malekshoar, Parisa Farnia and Ali Akbar Velayati
    Citation: Allergy, Asthma & Clinical Immunology 2022 18:96
    Content type: Case report Published on:

  7. Allergic rhinitis (AR) is frequent in children and adolescents and can severely affect their lives. This article describes the development and validation of a questionnaire to assess treatment needs and benefi...

    Authors: Toni Maria Janke, Elisabeth Eisner, Matthias Augustin and Christine Blome
    Citation: Allergy, Asthma & Clinical Immunology 2022 18:95
    Content type: Research Published on:

  8. Childhood adenoid hypertrophy (AH) is common and is often associated with allergic asthma, resulting in complications like obstructive sleep apnea syndrome (OSAS). Management of the disease and its complicatio...

    Authors: Haijing Sui, Huishan Zhang, Wei Ding, Zuotao Zhao, Jiali Mo, Jiexin Yuan and Leping Ye
    Citation: Allergy, Asthma & Clinical Immunology 2022 18:94
    Content type: Case report Published on:

  9. Idiopathic pulmonary fibrosis (IPF) is a fatal fibrotic lung disease with limited treatment options. Plumbagin (PL) is an herbal extract with diverse pharmacological effects that have been recently used to tre...

    Authors: Saber Mehdizadeh, Marjan Taherian, Paria Bayati, Kazem Mousavizadeh, Salar Pashangzadeh, Ali Anisian and Nazanin Mojtabavi
    Citation: Allergy, Asthma & Clinical Immunology 2022 18:93
    Content type: Research Published on:

  10. The effects of a delayed diagnosis of asthma on lung function in children have not been well investigated. Therefore, a retrospective cohort study was conducted in a children’s hospital to analyse the effect o...

    Authors: Xiaoling Wei, Min Xue, Jinyan Yan, Yuling Han, Yanqin Liu, Miao Liu, Jing Sun, Yun Zhang, Lu Cheng, Xiang Ma and Zhongtao Gai
    Citation: Allergy, Asthma & Clinical Immunology 2022 18:92
    Content type: Research Published on:

  11. Since the first reported case of COVID-19, infections due to the virus have ranged from mild to severe. Patients with inborn errors of immunity are thought to be at increased risk for infections such as COVID-...

    Authors: Babak Aberumand, Ramy Kamal, Brock McKinney and Stephen Betschel
    Citation: Allergy, Asthma & Clinical Immunology 2022 18:91
    Content type: Case report Published on:

  12. The lymphocyte transformation test (LTT) is an in vitro assay used to diagnose drug induced hypersensitivity reactions by detecting the activation and expansion of drug-specific memory T cells to the suspected...

    Authors: Chris Weir, Jamma Li, Richard Fulton and Suran L. Fernando
    Citation: Allergy, Asthma & Clinical Immunology 2022 18:90
    Content type: Research Published on:

  13. Dupilumab-induced ocular surface disease (DIOSD) has been reported in patients with atopic dermatitis treated with dupilumab, and has been recognized as an adverse event of dupilumab. Our objective was to desc...

    Authors: Rumi Adachi, Jun Shoji, Akira Hirota, Akiko Tomioka, Yukiko Tonozuka, Noriko Inada and Satoru Yamagami
    Citation: Allergy, Asthma & Clinical Immunology 2022 18:89
    Content type: Case report Published on:

  14. The proliferation of airway smooth muscle cells (ASMCs) contributes to the contractility and inflammation in the pathophysiology of asthma. This intrigued us to clarify the effect of microRNA (miR)-224-5p on b...

    Authors: Zhifang Zhuang, Yanjuan Zhou, Jiao Xu and Leying Pan
    Citation: Allergy, Asthma & Clinical Immunology 2022 18:88
    Content type: Research Published on:

  15. Immunoglobulin replacement therapy is the standard-of-care treatment for patients with primary immunodeficiency diseases who have impaired antibody production and function. Clinicians and patients may consider...

    Authors: Kristin Epland, Daniel Suez and Kenneth Paris
    Citation: Allergy, Asthma & Clinical Immunology 2022 18:87
    Content type: Review Published on:

  16. Fecal calprotectin (FC) is a noninvasive biomarker for assessing the inflammatory status of the gastrointestinal tract. The aim of this study was to determine the association between FC levels and Eosinophilic...

    Authors: Pejman Rohani, Narjes Raja Beheshti, Hosein Alimadadi and Mohammad Hassan Sohouli
    Citation: Allergy, Asthma & Clinical Immunology 2022 18:86
    Content type: Research Published on:

  17. The COVID-19 pandemic has highlighted disparities in healthcare, particularly in the United States, even though disparities have existed since the organization of the modern healthcare system. Recruitment of p...

    Authors: Timothy J. Craig, Rafael H. Zaragoza-Urdaz, H. Henry Li, Ming Yu, Hong Ren, Salomé Juethner and John Anderson
    Citation: Allergy, Asthma & Clinical Immunology 2022 18:85
    Content type: Short report Published on:

  18. Hereditary angioedema (HAE) is an inherited disease characterized by recurrent angioedema without urticaria or pruritus. The most common types of HAE are caused by deficiency or dysfunction in C1 esterase inhi...

    Authors: Yusuke Ushio, Risa Wakiya, Tomohiro Kameda, Shusaku Nakashima, Hiromi Shimada, Mai Mahmoud Fahmy Mansour, Mikiya Kato, Taichi Miyagi, Koichi Sugihara, Rina Mino, Mao Mizusaki, Emi Ibuki, Norimitsu Kadowaki and Hiroaki Dobashi
    Citation: Allergy, Asthma & Clinical Immunology 2022 18:84
    Content type: Case report Published on:

  19. Reports of allergic reactions to the COVID-19 vaccines have been documented, which may also contribute to hesitancy. Despite the low likelihood that the COVID-19 vaccine will trigger an allergic reaction, we a...

    Authors: Michael A. Golding, Nicole Askin, Ayel Luis R. Batac, Kaitlyn A. Merrill, Elissa M. Abrams, Philippe Bégin, Moshe Ben-Shoshan, Erika Ladouceur, Leslie E. Roos, Vladan Protudjer and Jennifer L. P. Protudjer
    Citation: Allergy, Asthma & Clinical Immunology 2022 18:83
    Content type: Research Published on:

  20. Anti-interferon-gamma autoantibody-associated immunodeficiency syndrome is a rare and underrecognized adult onset immunodeficiency syndrome associated with severe opportunistic infections such as disseminated ...

    Authors: Spencer Boyle, Ashley Hagiya, Minh-Vu H. Nguyen, Howard Liebman and Jin Sol G. Lee
    Citation: Allergy, Asthma & Clinical Immunology 2022 18:82
    Content type: Case report Published on:

  22. COVID-19 presents with a variable clinical course from asymptomatic to severe respiratory distress with nearly 25% mortality in mechanically-ventilated patients. As such, there is uncertainty regarding how hos...

    Authors: Kyle D. Miller, Amie M. Ashcraft, Courtney S. Pilkerton and Carl D. Shrader
    Citation: Allergy, Asthma & Clinical Immunology 2022 18:80
    Content type: Case report Published on:

  23. Asthma, allergic rhinitis and eczema have been identified as the most prevalent childhood allergic diseases. However, the prevalence of these allergic diseases can vary in different regions within a country an...

    Authors: Jagath C. Ranasinghe, Ruchira R. Karunarathne, Thilini S. Munasinghe, Gihani U. Vidanapathirana and Sanath T. Kudagammna
    Citation: Allergy, Asthma & Clinical Immunology 2022 18:79
    Content type: Research Published on:

  24. Oral corticosteroids reduce the antibody titer of the BNT162b2 mRNA vaccine against SARS-CoV-2. To date, the effect of inhaled corticosteroids on antibody titers is unknown.

    Authors: Takeo Nakajima, Tatsuya Nagano, Yoshiharu Miyata, Shoko Murakami, Satoshi Mitsuyuki, Yohei Funakoshi, Kimikazu Yakushijin, Hitoshi Horimoto, Yoshihiro Nishimura and Kazuyuki Kobayashi
    Citation: Allergy, Asthma & Clinical Immunology 2022 18:78
    Content type: Research Published on:

  25. Patterns of aeroallergen sensitization vary by countries. Testing with the minimum number of allergens is important to identify sensitized patients for a cost-effective approach. We aimed to assess the minimal...

    Authors: Prapasri Kulalert, Orapan Poachanukoon, Sira Nanthapisal, Paskorn Sritipsukho, Karnsinee Thanborisutkul, Pasistha Termworasin, Rungrawee Kornsawai and Patcharaporn Punyashthira
    Citation: Allergy, Asthma & Clinical Immunology 2022 18:77
    Content type: Research Published on:

  27. Allergies constitute an important public health problem, and epidemiological data is crucial to developing strategies for its prevention and therapy. Few population-based studies are available for data on alle...

    Authors: Felix King, Robert Kaczmarczyk, Alexander Zink, Tilo Biedermann and Knut Brockow
    Citation: Allergy, Asthma & Clinical Immunology 2022 18:75
    Content type: Research Published on:

  28. Although the prevalence of allergic diseases, including food allergies, has increased over recent decades, relevant information on this topic is still lacking, particularly in younger children living in small ...

    Authors: José A. da S. Correia, Adriana Azoubel Antunes, Luiz Taborda-Barata, José Laerte Boechat and Emanuel Sávio Cavalcanti Sarinho
    Citation: Allergy, Asthma & Clinical Immunology 2022 18:74
    Content type: Research Published on:

  29. Constipation has been hypothesized to be associated with the increased risk of wheezing or asthma. However, the relation remains a subject of debate. We conducted this meta-analysis to assess whether constipat...

    Authors: Lu Liu, Xiangli Zhang, Zhengdong Jiang, Guizuo Wang, Hua Wu, Ruilin Chen, Yongqing Zhang, Manxiang Li and Shumei Yang
    Citation: Allergy, Asthma & Clinical Immunology 2022 18:73
    Content type: Research Published on:

  30. We compared patient and caregiver knowledge and confidence for managing asthma, and participant experiences when comprehensive asthma education was delivered in person versus in the virtual setting.

    Authors: Dhenuka Radhakrishnan, Andrea Higginson, Madhura Thipse, Marc Tessier and Arun Radhakrishnan
    Citation: Allergy, Asthma & Clinical Immunology 2022 18:72
    Content type: Research Published on:

  31. Our recent observational study showed that regular consumption of cow’s milk (CM) formula during early infancy (3–6 months old) was associated with a reduced risk of CM allergy (CMA) at 12 months old. However,...

    Authors: Kota Ikari, Junichiro Tezuka, Masafumi Sanefuji, Jiro Nakayama, Daisuke Nishima, Yuri Sonoda, Masanobu Ogawa, Masayuki Shimono, Reiko Suga, Satoshi Honjo, Koichi Kusuhara and Shouichi Ohga
    Citation: Allergy, Asthma & Clinical Immunology 2022 18:71
    Content type: Research Published on:

  32. Real-world data on transitioning to Immune Globulin Subcutaneous (Human) 20% solution (Ig20Gly) are limited. This study aimed to assess infusion parameters and experience of patients with primary (PID) or seco...

    Authors: Paul K. Keith, Juthaporn Cowan, Amin Kanani, Harold Kim, Gina Lacuesta, Jason K. Lee, Jie Chen, Michelle Park and André Gladiator
    Citation: Allergy, Asthma & Clinical Immunology 2022 18:70
    Content type: Research Published on:

    The Correction to this article has been published in Allergy, Asthma & Clinical Immunology 2023 19:54

  33. Drug-induced hypersensitivity syndrome (DIHS) is a rare, potentially life-threatening systemic drug reaction. Antithyroid drugs (ATDs) causing DIHS have seldom been reported before.

    Authors: Fang Wu, Ting Jin, Chengxin Shang, Xihua Lin, Xiaoqin Gong and Zhou Wang
    Citation: Allergy, Asthma & Clinical Immunology 2022 18:69
    Content type: Case report Published on:

  34. Ear, nose, and throat involvement are common in eosinophilic granulomatosis with polyangiitis (EGPA). Among otologic manifestation, middle ear effusion (MEE) is less recognized but a problematic condition as i...

    Authors: Noeul Kang, Joongbo Shin, Yang-Sun Cho, Jin-Young Lee, Byung-Jae Lee and Dong-Chull Choi
    Citation: Allergy, Asthma & Clinical Immunology 2022 18:68
    Content type: Research Published on:

  35. Olfactory dysfunction is recognized as a symptom of COVID-19. Reports revealed the nasal calcium increase has adverse effects on olfactory function. Tetra sodium pyrophosphate, a chelating agent, can bind calc...

    Authors: Mohamed H. Abdelazim, Ahmed H. Abdelazim and Waleed Moneir
    Citation: Allergy, Asthma & Clinical Immunology 2022 18:67
    Content type: Research Published on:

  36. Several miRNAs are now known to have clear connections to the pathogenesis of asthma. The present study focused on the potential role of miR-3934 during asthma development.

    Authors: Liyan Dou, Wenyu Wang, Junwei Wang, Xiaofei Zhang, Xiaoman Hu, Weili Zheng, Kaiyu Han and Guangyou Wang
    Citation: Allergy, Asthma & Clinical Immunology 2022 18:66
    Content type: Research Published on:

  37. Authors: Ignacio J. Ansotegui, Jonathan A. Bernstein, Giorgio W. Canonica, Sandra N. Gonzalez-Diaz, Bryan L. Martin, Mario Morais-Almeida, Margarita Murrieta-Aguttes and Mario Sanchez Borges
    Citation: Allergy, Asthma & Clinical Immunology 2022 18:65
    Content type: Correction Published on:

    The original article was published in Allergy, Asthma & Clinical Immunology 2022 18:41

  38. Hereditary angioedema (HAE) is a rare, autosomal disorder that manifests with unpredictable episodes of severe swelling of the skin and mucous membranes. These attacks can be highly disfiguring and range in se...

    Authors: Florence Ida Hsu, William Lumry, Marc Riedl and Raffi Tachdjian
    Citation: Allergy, Asthma & Clinical Immunology 2022 18:64
    Content type: Review Published on:

    The Correction to this article has been published in Allergy, Asthma & Clinical Immunology 2022 18:81

  39. Allergen immunotherapy (AIT) is the only treatment that has modified the natural history of allergic diseases. However, since its overall effect on the immune system has not been elucidated, AIT is either abso...

    Authors: Kazuki Fujioka, Akiko Kasahara, Takashi Kida, Wataru Fujii, Takahiro Seno, Makoto Wada, Masataka Kohno and Yutaka Kawahito
    Citation: Allergy, Asthma & Clinical Immunology 2022 18:63
    Content type: Research Published on:

  40. Owing to a collaborative approach to patient care, and a paucity of allergists in Canada, there is a need to develop a food allergy educational program for allied health care professionals in Canada. Such prog...

    Authors: Jennifer L. P. Protudjer, Carina Venter, Marion Groetch, Tara Lynn Mary Frykas, Jasmin Lidington and Harold Kim
    Citation: Allergy, Asthma & Clinical Immunology 2022 18:62
    Content type: Letter to the editor Published on:

  41. Wheat-dependent exercise-induced anaphylaxis (WDEIA) is a serious and potentially life-threatening form of wheat allergy. Further episodes can only be prevented by avoiding wheat ingestion or avoiding exercise...

    Authors: Zhirong Du, Xiang Gao, Junda Li, Lun Li, Juan Liu and Jia Yin
    Citation: Allergy, Asthma & Clinical Immunology 2022 18:61
    Content type: Research Published on:

  42. Hereditary angioedema (HAE) is a rare, life-threatening disease. The knowledge about the molecular pathogenesis of HAE has derived mainly from investigating blood samples. However, limited data are available o...

    Authors: Henriette Farkas, Csilla Máj, István Kenessey, Anna Sebestyén, Ildikó Krencz, Judit Pápay and László Cervenak
    Citation: Allergy, Asthma & Clinical Immunology 2022 18:60
    Content type: Research Published on:

  43. Allergies, including food allergies, are a considerable clinical and public-health problem. The introduced preventive measures and differential diagnostics, including oral food challenges, are the gold standar...

    Authors: Edyta Krzych-Fałta, Oksana Wojas, Piotr Samel-Kowalik, Adam J. Sybilski and Bolesław Samoliński
    Citation: Allergy, Asthma & Clinical Immunology 2022 18:59
    Content type: Case report Published on:

  44. Kimura disease (KD) is a rare chronic idiopathic condition of unknown etiology that is prevalent in Asian males. It often causes subcutaneous lumps and enlarged lymph nodes, especially in head and neck region....

    Authors: Ruiyun Fan, Guopeng Xu, Ying Chen, Jinghuan Lv and Zhongwei Zhang
    Citation: Allergy, Asthma & Clinical Immunology 2022 18:58
    Content type: Case report Published on:

  45. The mechanism of action behind anaphylactic reactions to the mRNA COVID-19 vaccines remains unknown, but the excipient polyethylene glycol, PEG-2000, has been implicated. Initial recommendations were made for ...

    Authors: Daniel H. Li, Erika Lee and Christine Song
    Citation: Allergy, Asthma & Clinical Immunology 2022 18:57
    Content type: Case report Published on:

  46. Air pollution may induce or reinforce nasal inflammation regardless of allergy status. There is limited direct clinical evidence informing the treatment of airborne pollution-related rhinitis.

    Authors: Yuan Zhang, Chunguang Shan, Weiwei Liu, Yaozhong Han, Guanggang Shi, Yongjian Ma, Kerstin Wagner, Xiaoyan Tian, Lili Zhang, Allan Joseph Larona, Steven Sacavage, Kathleen Franklin, Chengshuo Wang and Luo Zhang
    Citation: Allergy, Asthma & Clinical Immunology 2022 18:56
    Content type: Research Published on:

  47. The microtubule-dependent molecular motor protein Kinesin Family Member 2A (KIF2A) is down-regulated in asthmatic human airway epithelium. However, little is known about the roles of KIF2A as well as the possi...

    Authors: Zhengxia Wang, Jingjing Wu, Jingxian Jiang, Qiyun Ma, Meijuan Song, Tingting Xu, Yanan Liu, Zhongqi Chen, Yanmin Bao, Mao Huang, Mingshun Zhang and Ningfei Ji
    Citation: Allergy, Asthma & Clinical Immunology 2022 18:55
    Content type: Research Published on:

  48. Food protein-induced enterocolitis syndrome is a non-IgE-mediated reaction to food that is poorly understood, and underdiagnosed. Trigger foods can belong to any food group, but are most commonly milk, soy, ri...

    Authors: Samantha Wong, Lucy Duan, Alana Galper, Adelle Atkinson, Julia Upton and Thomas Eiwegger
    Citation: Allergy, Asthma & Clinical Immunology 2022 18:54
    Content type: Letter to the editor Published on:

  49. Public health measures to mitigate the COVID-19 pandemic have altered health care for chronic conditions. The impact of the COVID-19 pandemic on paediatric asthma, the most common chronic respiratory cause of ...

    Authors: Nusrat Homaira, Nan Hu, Louisa Owens, Mei Chan, Melinda Gray, Philip N Britton, Hiran Selvadurai, Raghu Lingam and Adam Jaffe
    Citation: Allergy, Asthma & Clinical Immunology 2022 18:53
    Content type: Letter to the editor Published on:

  50. Platelet-activating factor (PAF) has been suggested to be a potent inflammatory mediator in Allergic rhinitis (AR) pathogenesis. Vitamin E, an essential nutrient that comprises tocopherol and tocotrienol, is k...

    Authors: Cheryl Wei Ling Teo, Stephanie Jia Ying Png, Yee Wei Ung and Wei Ney Yap
    Citation: Allergy, Asthma & Clinical Immunology 2022 18:52
    Content type: Research Published on:

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