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  1. There exists a geographic barrier to access CIA care for patients who live in rural communities; telemedicine may bridge this gap in care. Herein we characterized the use of telemedicine in CIA at a population...

    Authors: Erika Yue Lee, Christine Song, Peter Vadas, Matthew Morgan and Stephen Betschel
    Citation: Allergy, Asthma & Clinical Immunology 2021 17:131
  2. Epinephrine is the first line treatment for anaphylaxis, an acute potentially life-threatening allergic reaction. It is typically administered intramuscularly in the anterolateral thigh at a dose of 0.01 mg/kg...

    Authors: Lucy Dong Xuan Li, Elissa M. Abrams, Elana Lavine, Kyla Hildebrand and Douglas Paul Mack
    Citation: Allergy, Asthma & Clinical Immunology 2021 17:130
  3. The Global Initiative for Asthma has only recently added tiotropium bromide as adjunct controller therapy in severe asthma (Step 4 or 5) in adults (2015) and children (2019). Although not yet approved for pedi...

    Authors: Zainab Ridha, Marc-Antoine Bédard, Anna Smyrnova, Olivier Drouin, Aniela Pruteanu, Sandrine Essouri and Francine M. Ducharme
    Citation: Allergy, Asthma & Clinical Immunology 2021 17:129
  4. Refractory status asthmaticus is the cause of rare cases of in-hospital death due to acute bronchial asthma. The most severe cases unresponsive to first, second and next line treatment may be fatal despite agg...

    Authors: Jan Benes, Roman Skulec, Dalibor Jilek, Ondrej Fibigr and Vladimir Cerny
    Citation: Allergy, Asthma & Clinical Immunology 2021 17:128
  5. Post hoc analyses of randomized placebo-controlled trials have demonstrated efficacy and tolerability of the ragweed sublingual immunotherapy (SLIT)-tablet in Canadian adults with ragweed pollen-induced allerg...

    Authors: Anne K. Ellis, Remi Gagnon, David I. Bernstein and Hendrik Nolte
    Citation: Allergy, Asthma & Clinical Immunology 2021 17:127
  6. Dedicator of cytokinesis 2 (DOCK2) deficiency is an inborn error of immunity characterized by cellular and humoral immunological abnormalities leading to early-onset infections.

    Authors: Niusha Sharifinejad, Homa Sadri, Arash Kalantari, Samaneh Delavari, Amirhosein Noohi, Yasaman Aminpour, Araz Sabzevari and Gholamreza Azizi
    Citation: Allergy, Asthma & Clinical Immunology 2021 17:126
  7. Sublingual immunotherapy tablets (SLIT-T) are an effective treatment for allergic rhinitis (AR), but some patients experience local allergic reactions (LAR) in the first few weeks of treatment that can lead to...

    Authors: Anne K. Ellis, Lori Connors, Marie-Josee Francoeur and Douglas P. Mack
    Citation: Allergy, Asthma & Clinical Immunology 2021 17:125
  8. Granulomatosis with polyangiitis (GPA) is a syndrome of refractory vasculitis involving the upper respiratory tract, lungs, kidneys, and systemic small and medium-sized arteries that affects all age groups. No...

    Authors: Memi Kato, Keisuke Jimbo, Masumi Nagata, Yoshiko Endo, Kosuke Kashiwagi, Kimiko Maruyama, Natsuki Ito, Kaori Tokushima, Nobuyasu Arai, Reiko Kyodo, Masamichi Sato, Eri Miyata, Kenji Hosoi, Eisuke Inage, Tamaki Ikuse, Hideo Fukunaga…
    Citation: Allergy, Asthma & Clinical Immunology 2021 17:124
  9. Asthma is one of the most common chronic diseases in childhood and is generally characterized by exercise induced bronchoconstriction (EIB). Assessing EIB is time consuming and expensive as it requires a fully...

    Authors: M. R. van der Kamp, J. M. M. Driessen, M. P. van der Schee, B. J. Thio and F. H. C. de Jongh
    Citation: Allergy, Asthma & Clinical Immunology 2021 17:121
  10. The hygiene hypothesis posits that microbial exposure reduces risk of asthma and other respiratory-related diseases. Helicobacter pylori and hepatitis A virus (HAV) are common fecal–oral infections. Our study aim...

    Authors: Christian S. Alvarez, M. Larissa Avilés-Santa, Neal D. Freedman, Krista M. Perreira, Olga Garcia-Bedoya, Robert C. Kaplan, Martha L. Daviglus, Barry I. Graubard, Gregory A. Talavera, Bharat Thyagarajan and M. Constanza Camargo
    Citation: Allergy, Asthma & Clinical Immunology 2021 17:120
  11. Increased levels of serum Immunoglobulin-E (IgE) and different genetic variants of cytokines are common biochemical manifestation in Allergy. The current study was aimed to study the association of IgE and dif...

    Authors: Taha Ashraf Qurashi, Aaliya Shah, Gulzar Ahmad Bhat, Mosin Saleem Khan, Roohi Rasool and Syed Mudassar
    Citation: Allergy, Asthma & Clinical Immunology 2021 17:119
  12. Allergic bronchopulmonary aspergillosis (ABPA) and chronic eosinophilic pneumonia (CEP) both display peripheral eosinophilia as well as pulmonary infiltration, together described as pulmonary eosinophilia, and...

    Authors: Mari Miki, Yuko Ohara, Kazuyuki Tsujino, Takahiro Kawasaki, Tomoki Kuge, Yuji Yamamoto, Takanori Matsuki, Keisuke Miki and Hiroshi Kida
    Citation: Allergy, Asthma & Clinical Immunology 2021 17:118
  13. Symptom control is a major concern in chronic urticaria. Histobulinâ„¢ is a histamine/immunoglobulin complex that has been approved for allergic rhinitis, bronchial asthma and chronic urticaria in some countries...

    Authors: Hyuk Soon Kim and Geunwoong Noh
    Citation: Allergy, Asthma & Clinical Immunology 2021 17:116
  14. Severe combined immunodeficiency (SCID) is a rare genetic condition characterized by significant T cell lymphopenia and impaired T cell function. Many jurisdictions use the quantitation of T cell receptor exci...

    Authors: Adil Adatia, Ling Ling, Pranesh Chakraborty, Lauren Brick and Rae Brager
    Citation: Allergy, Asthma & Clinical Immunology 2021 17:115
  15. Periplaneta americana and Blattella germanica cockroaches are widespread, and risk of sensitization increases in urban environments where these roaches thrive as household pests. There are no prior reports of Bla...

    Authors: Hannah Wangberg, Jun Mendoza, Robert Gomez, Christopher Coop, Andrew White and Katharine Woessner
    Citation: Allergy, Asthma & Clinical Immunology 2021 17:114
  16. Allergic rhinitis (AR) is the most common undiagnosed chronic condition in children. Moderate/severe AR symptoms significantly impair quality of life, and cause sleep disruption, absenteeism and decreased prod...

    Authors: Eli O. Meltzer, Nelson Augusto Rosario, Hugo Van Bever and Luiz Lucio
    Citation: Allergy, Asthma & Clinical Immunology 2021 17:113

    The Correction to this article has been published in Allergy, Asthma & Clinical Immunology 2022 18:112

  17. Treatment with immune checkpoint inhibitors has revolutionized cancer treatment over the past several years. Despite their clinical benefits, a wide range of immune-mediated toxicities can be observed includin...

    Authors: Romy G. Younan, Roy A. Raad, Bassem Y. Sawan and Rabih Said
    Citation: Allergy, Asthma & Clinical Immunology 2021 17:112
  18. Several primary studies evaluated the association between rhinitis and the incidence of depression and yielded inconsistent results. We conducted a meta-analysis of studies evaluating the association between r...

    Authors: Jing Wang, Dongqiong Xiao, Huayou Chen and Juan Hu
    Citation: Allergy, Asthma & Clinical Immunology 2021 17:111
  19. Intimacy-related allergic reactions, including anaphylaxis, are under-reported due to social stigma, lack of awareness, and misdiagnosis. The differential diagnosis for intimacy-related anaphylaxis is extensiv...

    Authors: Lundy R. McKibbin, Sidney Kin-Hung Siu, Hannah T. Roberts, Michael Shkrum and Samira Jeimy
    Citation: Allergy, Asthma & Clinical Immunology 2021 17:110
  20. Currently there is no systematic review and meta-analysis of the global incidence rates of anaphylactic and nonanaphylactic reactions to SARS-CoV-2 vaccines in the general adult population.

    Authors: Saad Alhumaid, Abbas Al Mutair, Zainab Al Alawi, Ali A. Rabaan, Raghavendra Tirupathi, Mohammed A. Alomari, Aqeel S. Alshakhes, Abeer M. Alshawi, Gasmelseed Y. Ahmed, Hassan M. Almusabeh, Tariq T. Alghareeb, Abdulaziz A. Alghuwainem, Zainab A. Alsulaiman, Mohammed A. Alabdulmuhsin, Emad A. AlBuwaidi, Amjad K. Bu Dukhi…
    Citation: Allergy, Asthma & Clinical Immunology 2021 17:109
  21. The Global Initiative for Asthma recommends the use of as-needed low-dose inhaled corticosteroid (ICS)-formoterol as a preferred controller therapy for patients with mild asthma. These recommendations were bas...

    Authors: Mohsen Sadatsafavi, J. Mark FitzGerald, Paul M. O’Byrne, Mena Soliman, Niroshan Sriskandarajah, Colin Vicente and Sarowar Muhammad Golam
    Citation: Allergy, Asthma & Clinical Immunology 2021 17:108
  22. Severe combined immunodeficiency (SCID) is a group of relatively rare primary immunodeficiency disorders (PIDs), characterized by disturbed development of T cells and B cells, caused by several genetic mutatio...

    Authors: Fatemeh Sadat Mahdavi, Mohammad Keramatipour, Sarina Ansari, Samin Sharafian, Arezou Karamzade and Marzieh Tavakol
    Citation: Allergy, Asthma & Clinical Immunology 2021 17:107
  23. The symptoms of patients with respiratory disease are influenced by local environmental factors. The incidence of allergic rhinitis in grassland areas was significantly higher than that in non-grassland areas....

    Authors: Xu Xu, Long Qin, Lei Ren, Chengshuo Wang, Yuan Zhang and Luo Zhang
    Citation: Allergy, Asthma & Clinical Immunology 2021 17:106
  24. Since the outbreak of the novel coronavirus disease (COVID-19), the therapeutic and management options to reduce the burden of the COVID-19 disease are under investigation. IVIG therapy is used as an effective...

    Authors: Zahra Kolahchi, Hanye Sohrabi, Sara Ekrami Nasab, Hesan Jelodari Mamaghani, Maryam Keyfari Alamdari and Nima Rezaei
    Citation: Allergy, Asthma & Clinical Immunology 2021 17:105
  25. The determination of systemic inflammatory markers is one of the important directions to study the pathogenesis of asthma and improve the diagnosis of asthma. Current studies have found that the 14-3-3 protein...

    Authors: Decai Wang, Lizong Rao, Yalan Cui, Guoting Tang, Haiming Huang, Ting Yuan and Biwen Mo
    Citation: Allergy, Asthma & Clinical Immunology 2021 17:104
  26. C1 inhibitor (C1-INH) and complement 4 (C4) have historically been referred to as positive acute phase reactants, however this has never been evaluated in hereditary angioedema (HAE) patients. Low function of ...

    Authors: Peter Stepaniuk, Ana-Maria Bosonea, Persia Pourshahnazari, Adrienne Roos and Amin Kanani
    Citation: Allergy, Asthma & Clinical Immunology 2021 17:103
  27. Knowledge is limited about the relationship between clinical reactivity to foods through breastfeeding and long-term food allergy outcomes. We explored parent-perceived symptoms of food allergy via breastfeedi...

    Authors: Abigail Lang, Shrey Patel, Karen Rychlik, Deanna Caruso, Xiaobin Wang, Jacqueline A. Pongracic and Rajesh Kumar
    Citation: Allergy, Asthma & Clinical Immunology 2021 17:102
  28. Peanut and soybean allergies are listed as contraindication in the package leaflet of isotretinoin, a widely used treatment of acne vulgaris. Cross-reactivity between PR10-proteins in peanut, tree nuts, and so...

    Authors: Anna Bamidis and Silke C. Hofmann
    Citation: Allergy, Asthma & Clinical Immunology 2021 17:101
  29. Hereditary angioedema (HAE) is a rare genetic disorder characterized by unpredictable localized episodes of edema, which is frequently managed with long-term prophylactic medications. Until recently, long-term...

    Authors: Richard G. Gower and Mary Wilber
    Citation: Allergy, Asthma & Clinical Immunology 2021 17:100
  30. Jellyfish stings are known to induce allergic skin reactions; however, case reports of anaphylaxis after jellyfish ingestion have been increasing, especially in Asian countries. Some cases of anaphylaxis after...

    Authors: Mitsuru Tsuge, Masanori Ikeda, Osamu Mitani, Masato Yasui and Hirokazu Tsukahara
    Citation: Allergy, Asthma & Clinical Immunology 2021 17:99
  31. We present a case of CVID complicated by granulomatous interstitial lung disease (GLILD). This patient clinical course was further complicated by COVID-19 infection. This is only the 2nd known case report of C...

    Authors: Debendra Pattanaik, Shaunah Ritter and Joseph Fahhoum
    Citation: Allergy, Asthma & Clinical Immunology 2021 17:98
  32. Hen’s eggs are one of the most common causes of food allergy. Although hen’s eggs are known to cause more gastrointestinal symptoms than other foods, it is not known whether there is a difference in organ-spec...

    Authors: Kei Uneoka, Satoshi Horino, Ayafumi Ozaki, Haruka Aki, Masako Toda and Katsushi Miura
    Citation: Allergy, Asthma & Clinical Immunology 2021 17:97
  33. Atopic dermatitis is the most common chronic inflammatory skin disease and presents a major public health burden worldwide. Recent observational studies revealed the potential association between atopic dermat...

    Authors: Zhiyu Lu, Ni Zeng, Yuxin Cheng, Yihe Chen, Yueyue Li, Qian Lu, Qingyue Xia and Dan Luo
    Citation: Allergy, Asthma & Clinical Immunology 2021 17:96
  34. The prevalence of comorbidities and their relation to asthma control and treatment is a topic of increasing interest, however comprehensive studies are scarce. We aimed to determine the prevalence of the most ...

    Authors: Gábor Tomisa, Alpár Horváth, Balázs Sánta, András Keglevich and Lilla Tamási
    Citation: Allergy, Asthma & Clinical Immunology 2021 17:95
  35. It is well known that atopic dermatitis (AD) is associated with other allergic diseases. Recentely, links to diseases other than allergic disease have also been actively studied. Among them, the results of stu...

    Authors: Hye Jung Jung, Dong Heon Lee, Mi Youn Park and Jiyoung Ahn
    Citation: Allergy, Asthma & Clinical Immunology 2021 17:94
  36. There is currently a dramatic increase in the number of COVID-19 cases worldwide, and further drastic restrictions in our daily life will be necessary to contain this pandemic. The implications of restrictive ...

    Authors: Nicole Maison, Heidrun Herbrüggen, Bianca Schaub, Christina Schauberger, Svenja Foth, Ruth Grychtol, Mustafa Abdo, Henrik Watz, Wilfried Nikolaizik, Klaus F. Rabe, Matthias V. Kopp, Gesine Hansen, Erika von Mutius, Thomas Bahmer and Jimmy Omony
    Citation: Allergy, Asthma & Clinical Immunology 2021 17:93
  37. Allergen extracts used in subcutaneous immunotherapy can be standardized or non-standardized. Standardized extracts are available in specific biological potencies, presumably making their biological activity m...

    Authors: Benny Dua, Jane Park and Harold Kim
    Citation: Allergy, Asthma & Clinical Immunology 2021 17:92
  38. An allergy to kiwi is rare in Poland. Most (65–72%) of the patients who are allergic to kiwi report symptoms of an oral allergy syndrome (OAS); however, systemic manifestations (18–28%) have also been reported.

    Authors: Natalia Ukleja-Sokołowska, Robert Zacniewski, Kinga Lis, Magdalena Żbikowska-Gotz, Andrzej Kuźmiński and Zbigniew Bartuzi
    Citation: Allergy, Asthma & Clinical Immunology 2021 17:91
  39. Tocilizumab has been shown to be effective for treatment of juvenile idiopathic arthritis (JIA). To our knowledge, this is the first reported case of interstitial lung disease occurring shortly after tocilizum...

    Authors: Koichi Sugihara, Risa Wakiya, Hiromi Shimada, Mikiya Kato, Tomohiro Kameda, Shusaku Nakashima, Mai Mahmoud Fahmy Mansour, Yusuke Ushio, Norimitsu Kadowaki and Hiroaki Dobashi
    Citation: Allergy, Asthma & Clinical Immunology 2021 17:90
  40. Exercise-induced anaphylaxis (EIA) is a rare and potentially life-threatening disorder that can develop independently without food ingestion. Cold drinks can also trigger symptoms in some patients with cold-in...

    Authors: Chikako Motomura, Koji Ide, Terufumi Shimoda and Hiroshi Odajima
    Citation: Allergy, Asthma & Clinical Immunology 2021 17:89
  41. Toxic epidermal necrolysis (TEN)/Stevens–Johnson syndrome (SJS) is the spectrum of severe, acute, mucocutaneous, T-cell mediated delayed type IV hypersensitivity reaction and universally related to different d...

    Authors: Biniyam A. Ayele, Kemal Ali and Eliyas Mulatu
    Citation: Allergy, Asthma & Clinical Immunology 2021 17:88
  42. A formulation of black cumin (Nigella sativa L.), licorice (Glycyrrhiza glabra L.), anise (Pimpinella anisum L.) and tea (Camellia sinensis (L.) Kuntze) (denoted BLAB tea) is traditionally used to relief allergy ...

    Authors: Chengsong Liao, Yangyang Han, Zhijing Chen and Huricha Baigude
    Citation: Allergy, Asthma & Clinical Immunology 2021 17:87
  43. Increased intestinal permeability, either due to the exposure to antigens in asthmatic patients or due to a barrier defect, plays a critical role in susceptibility to environmental allergens. House dust mite a...

    Authors: Shereen A. Baioumy, Aya Elgendy, Shereen M. Ibrahim, Sara I. Taha and Shaimaa H. Fouad
    Citation: Allergy, Asthma & Clinical Immunology 2021 17:86
  44. Leveraging the data management resources of the Canadian Primary Care Sentinel Surveillance Network (CPCSSN) is a viable approach for describing the prevalence of allergic disease documented in primary care se...

    Authors: Alexander G. Singer, Leanne Kosowan, Nerissa Nankissoor, Ryan Phung, Jennifer L. P. Protudjer and Elissa M. Abrams
    Citation: Allergy, Asthma & Clinical Immunology 2021 17:85

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