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  1. Asthma is a common chronic disease characterized by episodic or persistent respiratory symptoms and airflow limitation. Asthma treatment is based on a stepwise and control-based approach that involves an itera...

    Authors: Alberto Papi, Francesco Blasi, Giorgio Walter Canonica, Luca Morandi, Luca Richeldi and Andrea Rossi
    Citation: Allergy, Asthma & Clinical Immunology 2020 16:75
  2. Despite the clinical importance of pollen allergens among Filipinos, few studies delve into the sensitization profiles of Filipinos against pollen allergens. This study determined the sensitization profile of ...

    Authors: Maureen Sabit, Cecil Wong, Agnes Andaya and John Donnie Ramos
    Citation: Allergy, Asthma & Clinical Immunology 2020 16:74
  3. Work-related asthma (WRA) accounts for up to 25% of all adults with asthma. Early diagnosis is key for optimal management as delays in diagnosis are associated with worse outcomes. However, WRA is significantl...

    Authors: Madison MacKinnon, Teresa To, Clare Ramsey, Catherine Lemière and M. Diane Lougheed
    Citation: Allergy, Asthma & Clinical Immunology 2020 16:73
  4. Non-communicable diseases, such as allergies, are influenced by both genetic and epigenetic factors. Perinatal determinants conceivably modify the epigenetic makeup of the developing fetal immune system preven...

    Authors: Samuel Schäfer, Anthony Liu, Dianne Campbell and Ralph Nanan
    Citation: Allergy, Asthma & Clinical Immunology 2020 16:71
  5. We present a case of the patient, who developed hypersensitivity reaction during the treatment of chronic lymphocytic leukemia. Bendamustine was suspected as a culprit agent. The patient as well as 3 controls ...

    Authors: Laura Malinauskiene, Kestutis Cerniauskas, Kotryna Linauskiene, Linas Griguola, Anzelika Chomiciene and Audra Blaziene
    Citation: Allergy, Asthma & Clinical Immunology 2020 16:70
  6. Substantial experimental studies suggest a role for helminthes infections in the pathogenesis of allergies, but epidemiologic data have been inconsistent. Unlike to asthma, the association between helminthes i...

    Authors: Iraj Mohammadzadeh, Sorena Darvish, Seyed Mohammad Riahi, Solmaz Alizadeh Moghaddam, Mohammad Pournasrollah, Mousa Mohammadnia-Afrozi and Ali Rostami
    Citation: Allergy, Asthma & Clinical Immunology 2020 16:69
  7. Adherence to asthma treatment among children is usually poor. We sought to explore whether electronic adherence monitoring combined with weekly feedback regarding adherence along with a reminder to use inhaled...

    Authors: Jiande Chen, Juan Xu, Liebin Zhao, Jing Zhang, Yong Yin and Fen Zhang
    Citation: Allergy, Asthma & Clinical Immunology 2020 16:68
  8. Human microbiota plays a fundamental role in modulating the immune response. Western environment and lifestyle are envisaged to alter the human microbiota with a new microbiome profile established in Chinese i...

    Authors: Jing Guo, Xiaoping Zhang, Aarti Saiganesh, Christopher Peacock, Shu Chen, Gary A. Dykes, Belinda J. Hales, Peter N. Le Souëf and Guicheng Zhang
    Citation: Allergy, Asthma & Clinical Immunology 2020 16:67
  9. Asthma is a disease characterised by hyper responsiveness and bronchoconstriction of airways, and is a major health burden globally. A dysfunction of the oxidant-antioxidant balance, termed oxidative stress, h...

    Authors: Yenuli Fernando, Pujitha Wickramasinghe, Udani De Silva, Malintha Alahakoon, K. W. D. A. Anuradha and Shiroma Handunnetti
    Citation: Allergy, Asthma & Clinical Immunology 2020 16:66
  10. Loss-of-function (LOF) mutations in signal transducer and activator of transcription 3 (STAT3) is one of the causes of STAT3 hyperimmunoglobulin E (IgE) syndrome (STAT3-HIES), while gain-of-function (GOF) muta...

    Authors: Li Lin, Ying Wang, Bijun Sun, Luyao Liu, Wenjing Ying, Wenjie Wang, Qinhua Zhou, Jia Hou, Haili Yao, Liyuan Hu, Jinqiao Sun and Xiaochuan Wang
    Citation: Allergy, Asthma & Clinical Immunology 2020 16:65
  11. Peanut allergy affects 3% of Australian children and has a higher risk of anaphylaxis than most food allergies. Predicting who is likely to develop anaphylaxis is still an inexact science. The fraction of exha...

    Authors: Elizabeth Percival, Rani Bhatia, Kahn Preece, Mark McEvoy, Adam Collison and Joerg Mattes
    Citation: Allergy, Asthma & Clinical Immunology 2020 16:64
  12. Although the diagnosis and management of chronic spontaneous urticaria (CSU) is well documented in the literature, some aspects of the disease remain unclear. We aimed to further describe the natural history, ...

    Authors: Peter Stepaniuk, Manstein Kan and Amin Kanani
    Citation: Allergy, Asthma & Clinical Immunology 2020 16:63
  13. Vitamin D deficiency or insufficiency, has been associated with atopy and lack of asthma control. Our objective was to investigate associations between variants in genes of vitamin D pathway with serum levels ...

    Authors: Alana Alcântara Galvão, Flávia de Araújo Sena, Emília Maria Medeiros de Andrade Belitardo, Maria Borges Rabelo de Santana, Gustavo Nunes de Oliveira Costa, Álvaro Augusto Cruz, Maurício Lima Barreto, Ryan dos Santos Costa, Neuza Maria Alcantara-Neves and Camila Alexandrina Figueiredo
    Citation: Allergy, Asthma & Clinical Immunology 2020 16:62
  14. The differentiation of CD4+ lymphocytes Th17/regulatory T cells (Treg) and indoleamine 2,3-dioxygenase (IDO) is associated with the pathogenesis of allergic asthma. Basic research has shown that IDO is likely ...

    Authors: Ying Hu, Zhiqiang Chen, Jing Zeng, Shouyan Zheng, Liujuan Sun, Li Zhu and Wei Liao
    Citation: Allergy, Asthma & Clinical Immunology 2020 16:61
  15. Dupilumab is a receptor antagonist binding to the alpha subunit of the interleukin-4 receptor. Through binding to it, dupilumab inhibits signaling of both IL-4 and IL-13, the representative Th2 biomarkers. Rec...

    Authors: Dong Hyek Jang, Jae In Lee, Joo Yoon Bae, Hye Jung Jung, Mi Yeon Park and Jiyoung Ahn
    Citation: Allergy, Asthma & Clinical Immunology 2020 16:60
  16. Mycobacterium vaccae nebulization imparted protective effect against allergic asthma in a mouse model. The TGF-β/Smad signal transduction pathway plays an important role in allergic bronchial asthma. However, the...

    Authors: Xiao-hong Jiang, Chao-qian Li, Guang-yi Feng, Ming-jie Luo and Qi-xiang Sun
    Citation: Allergy, Asthma & Clinical Immunology 2020 16:59
  17. The prevalence of allergic rhinitis (AR), an environment- and lifestyle-dependent condition, has been constantly increasing in Korea. Although the environment and lifestyle of the Korean people have recently u...

    Authors: Ji Heui Kim, Shin Ae Kim, Ja Yoon Ku, Won Ki Cho and Chol Ho Shin
    Citation: Allergy, Asthma & Clinical Immunology 2020 16:58
  18. Current recommendations for the management of penicillin allergy are to perform penicillin skin testing (PST) with penicilloyl-polylysine (PPL) and benzylpenicillin (BP) prior to drug challenge with amoxicilli...

    Authors: Roxane Labrosse, Louis Paradis, Kathryn Samaan, Jonathan Lacombe-Barrios, Jean Paradis, Philippe Bégin and Anne Des Roches
    Citation: Allergy, Asthma & Clinical Immunology 2020 16:57
  19. Allergic bronchopulmonary aspergillosis (ABPA) is a severe hypersensitivity reaction to aspergillus species colonizing the airways of patients with asthma or cystic fibrosis. Biologics including anti-IgE and a...

    Authors: Carlo Mümmler, Bernd Kemmerich, Jürgen Behr, Nikolaus Kneidinger and Katrin Milger
    Citation: Allergy, Asthma & Clinical Immunology 2020 16:55
  20. Common variable immunodeficiency (CVID) is the most common symptomatic primary immunodeficiency and has a broad spectrum of clinical manifestations. Among non-infectious complications, an increased incidence o...

    Authors: Veronica Pedini, Jacopo Umberto Verga, Irene Terrenato, Denise Menghini, Cristina Mezzanotte and Maria Giovanna Danieli
    Citation: Allergy, Asthma & Clinical Immunology 2020 16:54
  21. The role and importance of skin barrier as an immunologic organ and as a potent way of sensitization is well known. However, antibiotics anaphylaxis following skin sensitization has not been reported.

    Authors: N. Paradis, L. Marois, L. Paradis, F. Graham, P. Bégin and A. Des Roches
    Citation: Allergy, Asthma & Clinical Immunology 2020 16:51
  22. Neutrophils, eosinophils and inflammatory cells contribute to asthmatic inflammation. The anti-bactericidal/permeability-increasing protein (BPI), produced by neutrophils, peripheral blood monocytes or epithel...

    Authors: Chen Xingyuan and Qiu Chen
    Citation: Allergy, Asthma & Clinical Immunology 2020 16:50
  23. Omalizumab is approved for treating severe allergic asthma from age 6, but the definition of severe asthma including a systematic assessment to rule out difficult-to-treat asthma has changed since the drug was...

    Authors: Daniel P. Henriksen, Uffe Bodtger, Kirsten Sidenius, Niels Maltbaek, Lars Pedersen, Hanne Madsen, Ehm A. Andersson, Ole Norgaard, Louise K. Madsen and Bo L. Chawes
    Citation: Allergy, Asthma & Clinical Immunology 2020 16:49
  24. Omalizumab, mepolizumab, benralizumab, and dupilumab are the currently available biologics used to treat asthma in Japan. Anaphylaxis following treatment with mepolizumab or benralizumab is considered rare.

    Authors: Koichi Jingo, Norihiro Harada, Toshihiko Nishioki, Masahiro Torasawa, Tomoko Yamada, Tetsuhiko Asao, Haruhi Takagi, Tomohito Takeshige, Jun Ito and Kazuhisa Takahashi
    Citation: Allergy, Asthma & Clinical Immunology 2020 16:46
  25. MP-AzeFlu is relatively new a pharmaceutical drug used in the treatment of allergic rhinitis. It is comprised of azelastine hydrochloride (AZE), a potent histamine-H1-receptor antagonist and fluticasone propio...

    Authors: Sandra Ekstedt, Susanna Kumlien Georén and Lars Olaf Cardell
    Citation: Allergy, Asthma & Clinical Immunology 2020 16:45
  26. Several epidemiological studies have examined the possibility of a relationship between season of birth and atopic dermatitis (AD) and food allergy (FA), yet their results are contradictory. We investigated th...

    Authors: Yu Kuwabara, Ritsue Nii, Keiko Tanaka, Eiichi Ishii, Mizuho Nagao and Takao Fujisawa
    Citation: Allergy, Asthma & Clinical Immunology 2020 16:44
  27. Rare tonsillar granulomas may be caused for example by infections, malignancies or sarcoidosis. Granulomas also occur in inborn errors of immunity (IEI) such as common variable immunodeficiency (CVID) with B c...

    Authors: Aleksi Laajala, Outi Kuismin, Mikko Tastula, Leena Tiitto, Saila Kauppila, Anna Salo, Pirjo Åström, Antti Nissinen, Virpi Glumoff, Mikko R. J. Seppänen and Timo Hautala
    Citation: Allergy, Asthma & Clinical Immunology 2020 16:43
  28. In this letter to the editor, we present results of claims data analysis. This claims data analysis supports a hypothesis that in patients with hereditary angioedema due to C1-esterase inhibitor (C1-INH) defic...

    Authors: Henriette Farkas, Donald Levy, Dylan Supina, Melvin Berger, Subhransu Prusty and Moshe Fridman
    Citation: Allergy, Asthma & Clinical Immunology 2020 16:42
  29. Hereditary angioedema (HAE) is caused by a SERPING1 gene defect resulting in decreased (Type I) or dysfunctional (Type II) C1 esterase inhibitor (C1-INH). The prevalence of autoimmune diseases (ADs) in patient...

    Authors: Donald Levy, Timothy Craig, Paul K. Keith, Girishanthy Krishnarajah, Rachel Beckerman and Subhransu Prusty
    Citation: Allergy, Asthma & Clinical Immunology 2020 16:41
  30. Mucus hypersecretion and goblet cell upregulation are common features of chronic rhinosinusitis with nasal polyps (CRSwNP). Although epidermal growth factor (EGF) has been reported to stimulate the expression ...

    Authors: Jian Jiao, Tao Zhang, Yu Zhang, Jingyun Li, Min Wang, Ming Wang, Ying Li, Xiangdong Wang and Luo Zhang
    Citation: Allergy, Asthma & Clinical Immunology 2020 16:40
  31. Allergic rhinitis (AR) is an inflammatory disease of the nasal mucosa impacting up to 25% of Canadians. The standard of care for AR includes a treatment plan that takes into account patient preferences, the se...

    Authors: Lubnaa Hossenbaccus, Sophia Linton, Sarah Garvey and Anne K. Ellis
    Citation: Allergy, Asthma & Clinical Immunology 2020 16:39
  32. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Alexandra Langlois, Marie-Hélène Lavergne, Hélène Leroux, Kerstin Killer, Pauline Azzano, Louis Paradis, Kathryn Samaan, Jonathan Lacombe-Barrios, Thomas Eiwegger, Julia Upton, Gordon Sussman, Thomas Poder, Benoît Mâsse, Anne Des Roches and Philippe Bégin
    Citation: Allergy, Asthma & Clinical Immunology 2020 16:38

    The original article was published in Allergy, Asthma & Clinical Immunology 2020 16:25

  33. Ulcerative colitis (UC) is a chronic, non-specific inflammatory bowel disease (IBD) with unknown etiology. The lack of specific clinical manifestations, standard diagnostic criteria, objective and accurate ind...

    Authors: Yanhua Pang, Huijie Ruan, Dongfang Wu, Yanfei Lang, Ke Sun and Cuiping Xu
    Citation: Allergy, Asthma & Clinical Immunology 2020 16:37
  34. Quercetin is a naturally occurring polyphenol flavonoid which is rich in antioxidants. It has anti-allergic functions that are known for inhibiting histamine production and pro-inflammatory mediators. Querceti...

    Authors: Morteza Jafarinia, Mahnaz Sadat Hosseini, Neda kasiri, Niloofar Fazel, Farshid Fathi, Mazdak Ganjalikhani Hakemi and Nahid Eskandari
    Citation: Allergy, Asthma & Clinical Immunology 2020 16:36
  35. Antibiotics cause dramatic changes to the human microbiome. The composition of the microbiome has been associated with changes in the immune system and these changes are beginning to be linked to immune diseas...

    Authors: Rod A. Herman
    Citation: Allergy, Asthma & Clinical Immunology 2020 16:35
  36. Both intravenous and subcutaneous human immune globin G (IgG) replacement (IVIG and SCIG, respectively) reduce severe infection and increase serum IgG levels in primary immune deficiency disorder (PIDD) patien...

    Authors: Graham Walter, Chrystyna Kalicinsky, Richard Warrington, Marianne Miguel, Jeannette Reyes and Tamar S. Rubin
    Citation: Allergy, Asthma & Clinical Immunology 2020 16:34
  37. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Stephen Betschel, Jacquie Badiou, Karen Binkley, Rozita Borici-Mazi, Jacques Hébert, Amin Kanani, Paul Keith, Gina Lacuesta, Susan Waserman, Bill Yang, Emel Aygören-Pürsün, Jonathan Bernstein, Konrad Bork, Teresa Caballero, Marco Cicardi, Timothy Craig…
    Citation: Allergy, Asthma & Clinical Immunology 2020 16:33

    The original article was published in Allergy, Asthma & Clinical Immunology 2019 15:72

  38. We report a case of IgE-mediated hypersensitivity to lemon seed. We demonstrate for the first time a pattern of cross-sensitisation between seeds of citrus hybrid species from similar ancestral species origins.

    Authors: O. Stephanie Kayode, Nuevalynne Prado, David J. Thursfield, Stephen J. Till and Leonard Q. C. Siew
    Citation: Allergy, Asthma & Clinical Immunology 2020 16:32
  39. Allergen specific IgG4 levels have been monitored as a surrogate marker for the tolerance inducing effect of subcutaneous immunotherapy (SCIT) in many studies. Its accuracy at group level has been well establi...

    Authors: Dan Weinfeld, Ulla Westin, Laila Hellkvist, Ulf-Henrik Mellqvist, Ingvar Jacobsson and Lars-Olaf Cardell
    Citation: Allergy, Asthma & Clinical Immunology 2020 16:31
  40. Chronic rhinosinusitis (CRS) describes an inflammatory condition affecting the sinonasal mucosa. As the immune system players such as immunoglobulins play prominent roles in the development of CRS, we aimed to...

    Authors: Hossein Aazami, Farhad Seif, Babak Ghalehbaghi, Pegah Babaheidarian, Alireza Mohebbi, Aslan Ahmadi, Majid Khoshmirsafa, Sahand Ghalehbaghi, Babak Behnam, Kobra Zinat Entezami, Zahra Madjd and Reza Falak
    Citation: Allergy, Asthma & Clinical Immunology 2020 16:30
  41. The clinical efficacy of rupatadine in terms of responders has not been previously explored in perennial allergic rhinitis (PAR).

    Authors: Antonio Valero, Iñaki Izquierdo, Marek L. Kowalski, Glenis K. Scadding, Jean Bousquet and Joaquim Mullol
    Citation: Allergy, Asthma & Clinical Immunology 2020 16:29
  42. Mepolizumab (MEP) is the first anti Interleukin (IL)-5 add-on therapy approved for the treatment of severe refractory eosinophilic asthma.

    Authors: C. Caruso, S. Colantuono, D. Pugliese, C. Di Mario, B. Tolusso, E. Gremese, G. Papparella, F. Castrì, A. Gasbarrini, A. Romano and A. Armuzzi
    Citation: Allergy, Asthma & Clinical Immunology 2020 16:27
  43. A post hoc analysis of two randomized, placebo–controlled, Phase 3 trials of intravenous reslizumab, an anti-interleukin-5 (IL-5) biologic for severe eosinophilic asthma.

    Authors: J. Christian Virchow, Lisa Hickey, Evelyn Du and Margaret Garin
    Citation: Allergy, Asthma & Clinical Immunology 2020 16:26

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