From: Nonimmunoglobulin E-Mediated Immune Reactions to Foods
Disorder | Symptoms | Diagnostic Testing | Food Involved |
---|---|---|---|
Cutaneous | Â | Â | Â |
   Atopic dermatitis | Chronic relapsing pruritic rash | Skin testing and atopy patch testing | Milk, eggs, soy, peanuts, wheat |
   Dermatitis herpetiformis | Marked pruritus; papulovesicular rash over extensor surfaces and buttocks | Skin biopsy (IgA deposition), IgA antigliadin and antitransglutaminase antibodies; ± endoscopy | Gluten |
Gastrointestinal | Â | Â | Â |
   FPIES | Vomiting, diarrhea, progressing to shocklike state | Elimination diet, patch testing | Milk, soy, others |
   Eosinophilic esophagitis | Gastroesophageal reflux symptoms, dysphagia, failure to thrive | Elimination diet, skin testing and patch testing | Multiple foods |
   Celiac disease | Weight loss, chronic diarrhea, steatorrhea, abdominal distention | IgA antigliadin and antitransglutaminase antibodies, endoscopy | Gluten |
Respiratory | Â | Â | Â |
   Pulmonary hemosiderosis | Recurrent pneumonia, pulmonary infiltrates, iron deficiency anemia, failure to thrive | Clinical history, peripheral eosinophilia, milk precipitins (if caused by milk), ± lung biopsy, elimination diet | Milk, eggs |