Volume 6 Supplement 3

Fifth Annual Research Conference: Innovation from Cell to Society

Open Access

Characteristics of atopic asthma and non-atopic asthma in the Study of Asthma, Genes and the Environment (SAGE) Cohort at 11-13 years

  • J Pitt1,
  • AB Becker2 and
  • A Kozyrskyj3
Allergy, Asthma & Clinical Immunology20106(Suppl 3):P6

DOI: 10.1186/1710-1492-6-S3-P6

Published: 26 November 2010

Objective/purpose

Atopic and non-atopic asthma represent distinct phenotypes of childhood asthma. We hypothesize that there is an association between overweight/obesity and asthma in the absence of atopy and sought to further characterize these phenotypes at 11-13 years of age in a Canadian cohort.

Methods

The SAGE cohort includes 109 children with allergist-diagnosed atopic asthma (AA), 38 non-atopic asthmatics (NAA) and 185 control patients at the age of 11-13 years. Information on asthma symptoms and home environment was obtained from questionnaires. Anthropometric measurements and blood pressures were obtained. Spirometry was performed and cholesterol, LDL, HDL were measured. Statistical analysis was performed with SPSS-17.

Findings

NAA (7.8%) was less common than AA (22.4%).NAA vs. AA was 9.9%/20.8% in females, 6.2%/23.6% in males. Mean FEV1% predicted (87.8% vs. 87.3%) did not differ between the NAA's and AA's. Wheezing episodes in the last year (2.3 vs. 2.7 p = 0.426) and episodes of sleep disturbances due to wheeze (0.7 vs. 0.5 p = 0.280) were not significantly different. NAA's had slightly, but not significantly higher total cholesterol (4.0 mmol/L vs. 3.9 mmol/L), LDL (2.2 mmol/L vs. 2.0 mmol/L) and lower HDL (1.4 mmol/L vs. 1.49 mmol/L). For children with BMI >85%ile (n = 144), NAA's had higher mean cholesterol (p = 0.08). NAA's also had marginally higher systolic blood pressure (115.5 mmHg vs. 113 mmHg) but not statistically significant. Mean waist circumference (75.7 cm vs. 71.2 cm) and weight (54.6 kg vs. 50.7 kg) were higher in the NAA group but also not statistically significant. Early life tobacco exposure had an important influence on our subtypes. Interestingly, mothers of non-atopic asthmatics smoked fewer cigarettes/day in the first year of life (1.11 vs. 1.71 p = 0.025).

Deliverables

There is a trend towards higher cholesterol levels in overweight NAA's. There are no significant differences for asthma control between NAA's and AA's or blood lipids. AA's do have a higher burden of maternal tobacco smoke exposure in the first year of life than their NAA counterparts. This may suggest that environmental tobacco exposure is a risk factor in sensitization of AA's. We speculate that Vitamin D levels (a metabolite of cholesterol) may differ between the groups and analysis related to this is ongoing.

Relevance

It is increasingly important to better define phenotypes of asthma, especially in children. These findings will help to direct a focus for future and ongoing AllerGen research including the CHILD Study.

Authors’ Affiliations

(1)
Winnipeg Children's Hospital
(2)
Health Sciences Centre, Children's Hospital of Winnipeg
(3)
University of Alberta

Copyright

© Pitt et al; licensee BioMed Central Ltd. 2010

This article is published under license to BioMed Central Ltd.

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