From: A systematic review of CD14 and toll-like receptors in relation to asthma in Caucasian children
Gene | rs-number | Alleles | Number of associations | Minor allel related to | Association ref. | No association ref. |
---|---|---|---|---|---|---|
CD14 | rs2569190 | C > T | decreased asthma severity | [19] | ||
CD14 | rs4914 | G > C | decreased asthma incidence | [38] | ||
TLR1 | rs5743595 | T > C | 1 out of 1 | atopic asthma | [27] | NA |
TLR1 | rs4833095 | A > G | 1 out of 1 | atopic asthma | [27] | NA |
TLR2 | rs4696480 | A > T | asthma/current asthma symptoms | |||
TLR2 | rs3804099 | T > C | nonatopic asthma (inverse) | [27] | ||
TLR2 | rs3804100 | T > C | allergic asthma (inverse) | [38] | ||
TLR2 | rs1898830 | A > G | 1 out of 4 | asthma | [26] | |
TLR2 | rs5743708 | G > A | 1 out of 2 | asthma severity in atopic children | [59] | [43] |
TLR4 | rs2737190 | A > G | 1 out of 1 | (non-atopic) asthma | [27] | NA |
TLR4 | rs4986790 | A > G | 3 out of 10 | asthma, atopic asthma and asthma severity in atopic children | ||
TLR4 | rs4986791 | C > T | 1 out of 4 | mild atopic asthma | [34] | |
TLR6 | rs6531666 | T > C | 1 out of 1 | asthma | [45] | NA |
TLR6 | rs5743789 | T > A | 1 out of 1 | atopic asthma | [27] | NA |
TLR6 | rs5743798 | C > T | 1 out of 1 | asthma | [45] | NA |
TLR6 | rs5743810 | C > T | 2 out of 5 | (atopic) asthma | ||
TLR7 | rs179008 | A > T | 1 out of 2 | asthma | [28] | [27] |
TLR8 | rs2407992 | G > C | 1 out of 1 | asthma | [28] | NA |
TLR9 | rs187084 | T > C | 1 out of 3 | asthma | [27] | |
TLR10 | rs4129009 | A > G | 1 out of 2 | atopic asthma inverse | [27] | [45] |
TLR10 | rs11096957 | A > C | 1 out of 3 | asthma | [21] |