Fig. 2

Correlation of frequency of TIGIT-expressing CD3⁺CD4⁺ T lymphocytes with markers of T cell activation and other costimulatory molecules. a The frequency of CD69-expressing CD3⁺CD4⁺ T lymphocytes was significantly increased in SLE patients compared to HCs (P = 0.019). b The frequency of CD69-expressing CD3⁺CD8⁺ T lymphocytes was similar between HCs and SLE (P = 0.69). c The frequency of CD69-expressing CD3⁺CD4⁺ TIGIT⁺ T lymphocytes was significantly elevated compared to CD3⁺CD4⁺ TIGIT⁻ T lymphocytes in SLE patients (P = 0.023). d The frequency of PD1-expressing CD3⁺CD4⁺ T lymphocytes was significantly increased in SLE patients compared to HCs (P = 0.013). e The frequency of PD1-expressing CD3⁺CD8⁺ T lymphocytes was significantly increased in SLE patients compared to HCs (P = 0.0024). f The frequency of PD1-expressing CD3⁺CD4⁺ TIGIT⁺ T lymphocytes was similar to CD3⁺CD4⁺ TIGIT⁻ T lymphocytes (P = 0.94). g The frequency of PD-L1-expressing CD3⁺CD4⁺ T lymphocytes was significantly increased in SLE patients compared to HCs (P = 0.0004). h The frequency of PD-L1-expressing CD3⁺CD8⁺ T lymphocytes was significantly increased in SLE patients compared to HCs (P < 0.0001). i The frequency of PD-L1-expressing CD3⁺CD4⁺ TIGIT⁺ T lymphocytes was similar to CD3⁺CD4⁺ TIGIT⁻ T lymphocytes (P = 0.27)