From: Nasal nitric oxide in allergic rhinitis in children and its relationship to severity and treatment
Mild (n = 50) | Moderate+ (n = 44) | P | |
---|---|---|---|
Age at diagnosis, years | 4.5 ± 2.1 | 4.2 ± 2.1 | <0.001 |
Disease duration, months | 12 (4, 24) | 24 (8, 48) | <0.001 |
Post-treatment change in nNO concentration, ppb | −69.5 (−118.0, −36.0) | −191.0 (−301.0, −90.0) | <0.001 |
RQLO, pointsa | 0.17 (0, 0.96) | 2.08 (1.02, 2.64) | <0.001 |
Inconvenience due to stuffy nose | 0 (0, 2) | 4 (0, 4.5) | <0.001 |
Inconvenience due to sneezing | 0 (0, 1) | 2 (1, 3) | <0.001 |
Inconvenience due to runny nose | 0 (0, 1) | 2 (0.5, 3) | <0.001 |
Inconvenience due to itchy nose | 0 (0, 2) | 2 (0.5, 4.5) | <0.001 |
Inconvenience due to itchy eyes | 0 (0, 1) | 2 (0, 3.5) | <0.001 |
Inconvenience due to watery eyes | 0 (0, 0) | 1 (0, 1.5) | 0.001 |
Inconvenience due to red eyes | 0 (0, 0) | 1 (0, 2) | 0.001 |
Inconvenience due to swollen eyes | 0 (0, 0) | 0.5 (0, 1) | <0.001 |
Inconvenience due to painful eyes | 0 (0, 0) | 0 (0, 1) | <0.001 |
Rubbing nose or eyes repeatedly | 0 (0, 2) | 3 (1, 5) | <0.001 |
Postnasal drip | 0 (0, 2) | 3 (1, 5) | <0.001 |
Having to carry handkerchiefs | 0 (0, 0) | 2 (0, 4) | <0.001 |
Having to take medications | 0 (0, 0) | 0 (0, 1) | <0.001 |
Interference with leisure activities | 0 (0, 0) | 1 (0, 3) | <0.001 |
Inconvenience due to dry throat | 0 (0, 0) | 1 (0, 2.5) | <0.001 |
Inconvenience due to itchy throat | 0 (0, 0) | 2 (0, 3) | <0.001 |
Inconvenience due to headache | 0 (0, 0) | 0 (0, 1) | 0.054 |
Inconvenience due to fatigue | 0 (0, 1) | 1.5 (0, 3) | <0.001 |
Interference with mood | 0 (0, 0) | 2 (0, 3.5) | <0.001 |
Interference with attention | 0 (0, 1) | 2 (0, 4) | <0.001 |
Interference with sleep | 0 (0, 1) | 1 (0, 2.5) | <0.001 |
Frequent nocturnal awakening | 0 (0, 1) | 1 (0, 2) | 0.001 |
Irritable/anxiety/angry | 0 (0, 1) | 2 (0, 4) | <0.001 |
Embarrassed because of nasal symptoms | 0 (0, 0) | 1 (0, 1) | <0.001 |