Fig. 4
From: Regulation of Th2 responses by different cell types expressing the interleukin-31 receptor
Decreased antigen-specific proliferative and Th2 cytokine responses of spleen cells from IL-31RA−/− mice nasally injected with Cry j 2. Seven days after 19 nasal administrations of Cry j 2, spleen cells from six representative IL-31RA−/− and littermate control IL-31RA+/− mice were cultured for 88 h in the presence or absence of the indicated dose of Cry j 2 and pulsed for the last 16 h with 0.5 μCi of tritiated thymidine to analyze antigen-specific T-cell proliferative responses (a). Supernatants from 72-h cell cultures were assayed for IL-13 (b) and IL-5 (c). Data are presented as the mean ± SD