Table 1 Comparison of demographic, clinical and immunological data of SIgAD patients with severe and mild phenotypes
From: B cells and T cells abnormalities in patients with selective IgA deficiency
Parameter | All patients (n = 30) | Severe (n = 12) | Mild (n = 18) | p-value |
|---|---|---|---|---|
Age, year (IQR) | 11 (7.3–16) | 14 (6.3–34.5) | 10 (7.7–14.2) | 0.27 |
Age of onset, year (IQR) | 4 (2–8.75) | 8 (3–26) | 3 (1.1–5.5) | 0.05 |
Age of diagnosis, year (IQR) | 8 (5.5–13.7) | 9 (8–26) | 8 (3.5–9) | 0.06 |
Diagnostic delay, year (IQR) | 2 (1.1–4.7) | 3 (1–5) | 0.9 (2–4.7) | 0.8 |
Sex (Male/Female) | 23/7 | 9/3 | 14/4 | 1.0 |
Lymphocytes, cell/ul (IQR) | 4495 (3175–6325) | 3650 (2300–5550) | 4650 (4100–6725) | 0.059 |
Lymphocytes % of leukocytes (IQR) | 62 (43–77) | 43 (39–58) | 70 (55–78) | 0.61 |
Neutrophil % of leukocytes (IQR) | 45(37–56.5) | 52.7 (46–63.7) | 42.5 (32–51.5) | 0.04 |
CD3% of lymphocytes (IQR) | 60 (53–67) | 53 (50.2- 63) | 65 (57–70) | 0.08 |
CD4% of lymphocytes (IQR) | 35.5 (31–40.7) | 33.5 (31.5–40.7) | 36 (34–40.5) | 0.38 |
CD8% of lymphocytes (IQR) | 25 (19.7–30.5) | 17.5 (16.2–20.2) | 26 (22–31) | 0.02 |
CD19% of lymphocytes (IQR) | 16 (11.5–29.5) | 15.5 (8.2–32.5) | 16 (13.5–23) | 0.81 |
IgG, mg/dl (IQR) | 1380 (1006–1680) | 1630 (1180–1931) | 1216 (793–1534) | 0.22 |
IgA, mg/dl (IQR) | 0.5 (0–4.5) | 2 (0–5.5) | 0.3 (0–4.0) | 0.77 |
IgM, mg/dl (IQR) | 62.5 (59–119) | 80 (118–175) | 59.5 (49–92) | 0.03 |
IgE, IU/ml (IQR) | 43 (12.7–87) | 32.5 (2.5–180) | 49.5 (16.5–75) | 0.84 |