Table 2 Distribution of normal, increased and decreased proportions of T cell and B cell subsets in all SIgAD patients. N = 30
From: B cells and T cells abnormalities in patients with selective IgA deficiency
B cell subsets | Normal N (%) | Increased N (%) | Decreased N (%) |
|---|---|---|---|
CD19+ B cells | 26 (87%) | 4 (13%) | 0 |
Naïve B cells (CD19+, CD27−, IgM+, IgD+) | 21 (70%) | 8 (27%) | 1 (3%) |
Marginal zone-like B cells (CD19+, CD27+, IgM++, IgD+) | 26 (87%) | 2 (7%) | 2 (7%) |
Switched memory B cells (CD19+, CD27+, IgM−, IgD−) | 23 (77%) | 0 | 7 (23%) |
IgM-only memory B cells (CD19+, CD27+, IgM++, IgD−) | 29 (97%) | 0 | 1 (3%) |
CD21low B cells (CD19+, CD21−/low, CD38−/low, IgM+++) | 29 (97%) | 1 (3%) | 0 |
Transitional B cells (CD19+, CD21+, CD38++, IgM+) | 24 (80%) | 4 (13%) | 2 (7%) |
Plasmablasts (CD19+, CD21−/low, CD38++/+++, IgM−) | 26 (87%) | 1 (3%) | 3 (10%) |
CD4+ T cells | 25 (83%) | 3 (10%) | 2 (7%) |
Naïve T cells (CD4+, CD45RA+, CCR7+) | 23 (77%) | 6 (20%) | 1 (3%) |
Central memory cells (CD4+, CD45RA−, CCR7+) | 21 (70%) | 1 (3%) | 8 (27%) |
Effector memory cells (CD4+, CD45RA−, CCR7−) | 22 (73%) | 0 | 8 (27%) |
TEMRA cells (CD4+, CD45RA+, CCR7−) | 20 (67%) | 10 (33%) | 0 |
Th1 (CD4+, IFN-γ+) | 26 (87%) | 1 (3%) | 3 (10%) |
Th2 (CD4+, IL-4+) | 27 (90%) | 0 | 3 (10%) |
Th17 (CD4+, IL-17A+) | 27 (90%) | 3 (10%) | 0 |
Regulatory T cells (CD4+, CD25+, FoxP3+, CD127− /low) | 10 (33%) | 0 | 20 (67%) |
CD8+ T cells | 28 (93%) | 2 (7%) | 0 |
Naïve T cells (CD8+, CD45RA+, CCR7+) | 26 (87%) | 1 (3%) | 3 (10%) |
Central memory T cells (CD8+, CD45RA−, CCR7+) | 27 (90%) | 0 | 3 (10%) |
Effector memory T cells (CD8+, CD45RA−, CCR7−) | 25 (83%) | 0 | 5 (17%) |
TEMRA T cells (CD8+, CD45RA+, CCR7−) | 18 (60%) | 11 (37%) | 1 (3%) |