| Overall (N = 225) | US (n = 56) | Canada (n = 51) | Germany (n = 45) | Australia (n = 35) | UK (n = 24) | Italy (n = 14) |
---|---|---|---|---|---|---|---|
Follow-up duration (y), mean ± SD | 5.5 ± 4.2 | 5.2 ± 4.0 | 7.0 ± 4.2 | 5.6 ± 3.4 | 5.9 ± 5.9 | 5.0 ± 2.3 | 1.3 ± 1.2 |
Year of index date, n (%)a | |||||||
 2008 or earlier | 37 (16.4) | 5 (8.9) | 17 (33.3) | 9 (20.0) | 6 (17.1) | 0 | 0 |
 2009–2011 | 52 (23.1) | 20 (35.7) | 9 (17.6) | 8 (17.8) | 8 (22.9) | 7 (29.2) | 0 |
 2012–2014 | 56 (24.9) | 8 (14.3) | 19 (37.3) | 13 (28.9) | 7 (20.0) | 6 (25.0) | 3 (21.4) |
 2015–2017 | 69 (30.7) | 18 (32.1) | 6 (11.8) | 13 (28.9) | 12 (34.3) | 10 (41.7) | 10 (71.4) |
 2018 or later | 11 (4.9) | 5 (8.9) | 0 | 2 (4.4) | 2 (5.7) | 1 (4.2) | 1 (7.1) |
Age at index date, mean ± SDa | 36.8 ± 15.6 | 34.0 ± 12.9 | 35.7 ± 16.6 | 42.3 ± 15.8 | 32.1 ± 14.0 | 41.7 ± 17.6 | 38.0 ± 16.0 |
Female sex, n (%) | 141 (62.7) | 39 (69.6) | 35 (68.6) | 27 (60.0) | 18 (51.4) | 16 (66.7) | 6 (42.9) |
Race/ethnicity, n (%) | |||||||
 White | 194 (86.2) | 52 (92.9) | 51 (100.0) | 27 (60.0) | 32 (91.4) | 22 (91.7) | 10 (71.4) |
 Otherb | 7 (3.1) | 4 (7.1) | 0 | 0 | 3 (8.6) | 0 | 0 |
 Unknown | 24 (10.7) | 0 | 0 | 18 (40.0) | 0 | 2 (8.3) | 4 (28.6) |
Type of HAE, n (%) | |||||||
 Type 1 | 203 (90.2) | 46 (82.1) | 49 (96.1) | 40 (88.9) | 31 (88.6) | 23 (95.8) | 14 (100.0) |
 Type 2 | 22 (9.8) | 10 (17.9) | 2 (3.9) | 5 (11.1) | 4 (11.4) | 1 (4.2) | 0 |
Family history of HAE, n (%) | |||||||
 Yes | 160 (71.1) | 46 (82.1) | 33 (64.7) | 27 (60.0) | 24 (68.6) | 20 (83.3) | 10 (71.4) |
 No | 38 (16.9) | 8 (14.3) | 13 (25.5) | 8 (17.8) | 2 (5.7) | 3 (12.5) | 4 (28.6) |
 Unknown | 27 (12.0) | 2 (3.6) | 5 (9.8) | 10 (22.2) | 9 (25.7) | 1 (4.2) | 0 |
Comorbidities, (%)c | |||||||
 Any comorbidities | 105 (46.7) | 29 (51.8) | 34 (66.7) | 12 (26.7) | 17 (48.6) | 9 (37.5) | 4 (28.6) |
  Allergy or anaphylaxisd | 36 (16.0) | 8 (14.3) | 18 (35.3) | 2 (4.4) | 7 (20.0) | 0 | 1 (7.1) |
  Metabolice | 25 (11.1) | 10 (17.9) | 6 (11.8) | 3 (6.7) | 4 (11.4) | 2 (8.3) | 0 |
  Psychiatricf | 25 (11.1) | 9 (16.1) | 8 (15.7) | 1 (2.2) | 6 (17.1) | 1 (4.2) | 0 |
  Cardiovascularg | 22 (9.8) | 5 (8.9) | 5 (9.8) | 4 (8.9) | 4 (11.4) | 3 (12.5) | 1 (7.1) |
  Gastrointestinalh | 20 (8.9) | 2 (3.6) | 13 (25.5) | 0 | 3 (8.6) | 1 (4.2) | 1 (7.1) |
  Canceri | 9 (4.0) | 0 | 6 (11.8) | 1 (2.2) | 1 (2.9) | 1 (4.2) | 0 |
  Autoimmunej | 3 (1.3) | 0 | 1 (2.0) | 2 (4.4) | 0 | 0 | 0 |