Fig 1
From: Prurigo Nodularis onset during secukinumab treatment of psoriasis: a case report
Figures 1, 2 and 3 show the multiple edematous red solid papules on the extensor side of extremities, in the form of soy or hemispherical nodules, with some visible as ulcerated crusts, firm to touch. Figure 4a (HE staining, x10), Fig. 4b (HE staining, x40) show the typical pathological features of PN in patient’s biopsy, with dense epidermis, hyperkeratosis and acanthosis and vascular proliferation and dilatation in the dermal papilla and the reticular layer as well as mild infiltration of peritubular inflammatory cells, mainly lymphocytes, histiocytes, and plasma cells