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Table 1 The pooled prevalence of infections in selective IgA deficiency patients

From: Clinical manifestation for immunoglobulin A deficiency: a systematic review and meta-analysis

Type of infection

Ref

N*, sample size

ES% (95%CI); I2%

Respiratory tract infection

(16,17,18,19, 22,23,24, 27, 29, 32, 33, 45, 51, 67,68,69,70,71)

19, 1389

50.74 (40.24 to 61.21); 93.08

Pneumonia**

(8, 18, 19, 21, 25, 27, 29, 45, 67,68,69, 72, 73)

13, 892

12.15 (5.00 to 21.53); 92.07

Otitis

(8, 19, 21, 25, 29, 72)

6, 416

7.19 (2.61 to 13.51); 74.95

Sinusitis**

(8, 19, 29, 67)

4; 294

8.13 (0.54 to 21.64); 88.99

Gastrointestinal infection

(16, 22, 23, 27, 29, 32)

6, 352

15.79 (6.52 to 27.83); 85.54

Skin infection

(8, 15, 16, 19, 32, 45)

6, 456

15.31 (2.17 to 36.27); 96.15

Conjunctivitis

(8, 21)

2, 77

12.86 (6.01 to 21.55); NA

Bacterial infection

(8, 33)

2, 150

8.73 (4.52 to 14.00); NA

Viral infection

(15, 23,24,25, 32, 51, 67)

7, 507

3.99 (0.69 to 9.21); 79.63

Parasitic infection

(8, 23)

2, 85

1.72 (0.0 to 6.25); NA

Fungal infection

(8, 23)

2, 85

18.48 (10.72 to 27.65); NA

  1. *Number of studies in Meta-analysis
  2. ** Due to the high prevalence of pneumonia and sinusitis, these two variables were analyzed separately from other respiratory tract infections