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Table 2 The pooled prevalence of autoimmunity in selective IgA deficiency patients

From: Clinical manifestation for immunoglobulin A deficiency: a systematic review and meta-analysis

Type of autoimmunity

Ref

N*, sample size

ES% (95%CI); I2%

AIHA

(16, 18, 29, 45)

4, 326

1.48 (0.0 to 4.68); 44.75

ITP

(16, 18, 19, 22, 29, 31, 33, 74)

8, 577

1.61 (0.41 to 3.34); 20.33

Evans syndrome

(18, 19)

2, 119

0.42 (0.0 to 3.54); NA

Autoimmune thyroiditis

(15, 18, 22, 23, 31, 32, 45, 51, 53, 67, 70, 75)

12, 2868

2.99 (1.52 to 4.81); 51.21

IBD

(18, 25, 51, 53, 70, 73)

6, 2429

4.01 (0.71 to 9.11); 84.96

IDDM

(18, 23, 25, 29, 31, 33, 53, 67, 70, 73, 75)

11, 2801

3.29 (2.02 to 4.79); 28.21

Celiac disease

(8, 18, 23, 25, 31, 33, 40, 45, 51, 53, 68, 70,71,72,73, 76, 77)

17, 3813

6.57 (3.83 to 9.88); 86.91

Vitiligo

(18, 25, 31, 40, 45, 51, 75)

7, 872

1.40 (0.62 to 2.19); 0.0

Rheumatoid arthritis

(15, 16, 18, 19, 22, 29, 31, 33, 45, 51, 53, 67, 69,70,71,72, 74)

17, 3225

3.80 (1.66 to 6.56); 81.49

SLE

(15, 18, 19, 22, 29, 32, 40, 45, 53, 70, 74)

11, 3088

3.56 (1.07 to 7.09); 87.95

Sjogren syndrome

(18, 19, 40, 51, 67, 70, 74)

7, 768

0.94 (0.08 to 2.38); 25.67

Myasthenia gravis

(18, 53)

2, 2110

< 0.001 (0.0 to < 0.001); NA

Psoriasis

(16, 18, 19, 25, 33, 40, 51, 69, 74)

9, 939

1.47 (0.64 to 2.54); 0.0

Pernicious anemia

(18, 25, 29, 51, 74)

5, 402

0.70 (0.0 to 2.16); 0.0

  1. * Number of studies in Meta-analysis
  2. AIHA: Autoimmune hemolytic anemia, ITP: Idiopathic thrombocytopenic purpura, GBS: Guillain-Barré syndrome,
  3. IBD: Inflammatory bowel disease, IDDM: Insulin-dependent diabetes mellitus, SLE: systemic lupus erythematosus