Table 2 Classification of NSAIDs by degree of COX inhibition [11, 13]
From: A case of possible anaphylaxis to ASA and structurally unrelated NSAIDs
COX Inhibition | Examples | COX-1 Inhibition | COX-2 Inhibition |
|---|---|---|---|
Strong COX-1 Inhibition | ASA, Ibuprofen, Naproxen (non-selective NSAIDs) | ++ | At high doses |
Weak COX-1 Inhibition | Acetaminophen | Partial (at high doses) | Preferential (at low doses) |
Preferential COX-2 Inhibition | Meloxicam | Partial (at high doses) | + |
Selective COX-2 Inhibition | Celecoxib | - | ++ |