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Table 2 Humoral immune response after the second and third doses of SARS-CoV-2 vaccine

From: Immune response after SARS-CoV-2 vaccination in patients with inflammatory immune-mediated diseases receiving immunosuppressive treatment

Serum anti-SARS-Cov-2 antibody levels (IU/ml) after the 2nd vaccine

Controls

n = 38

All patients

n = 66

TNFi

n = 34

RTX

n = 27

Anti-IL6R

n = 2

JAKi

n = 3

p

625 (405–932)

94 (42–204)

123 (43–204)

4 (0–51)

64 (61–64)

40 (18–58)

< 0.0005

Serum anti- SARS-CoV-2 antibody levels (IU/ml) after the 3rd vaccine

 

All patients

N = 83

TNFi

n = 44

RTX

n = 29

Anti-IL6R

n = 5

JAKi

n = 5

 

40 (6.20–153)

80 (31–204)

3 (0–27)

153 (12–196)

35 (21–562)

0.03

  1. Anti-SARS-CoV-2 antibody levels were compared between controls and patients only after the second dose of the vaccine. Of the total of 86 patients, 66 and 83 patients had samples available after the second and third doses of vaccine, respectively. Patients treated with anti-IL6R agents and JAKi were not included in the statistical comparisons owing to the small sample size. All data are expressed as median (IQR)