Fig. 3

Patients with AR were divided into three groups according to different types of allergen positivity: perennial allergen group, seasonal allergen group and mixed allergen group. The test data did not conform to a normal distribution, so the Kruskal-Wallis H test was used to compare the differences in the levels of IL-36 family cytokines among the three groups, and the Bonferroni method was further used for pairwise comparison if the differences were statistically significant. (a) There was no significant difference in peripheral blood IL-36α concentration among the three groups of patients with AR; (b) There was no significant difference in peripheral blood IL-36β concentration among the three groups of patients with AR; (c) There was no significant difference in peripheral blood IL-36γ concentration among the three groups of patients with AR; (d) Peripheral blood IL-36Ra concentration in patients with AR in the seasonal allergen group was higher than that in the perennial allergen group with a statistically significant difference (P = 0.018), and there was no significant difference in peripheral blood IL-36Ra concentration between patients with AR in the mixed allergen group and those in the perennial allergen group and seasonal allergen group; (e) There was no significant difference in peripheral blood IL-38 concentration among the three groups of patients with AR. AR allergic rhinitis; IL interleukin