Table 1 Diagnostic Criteria for DRESS
From: Fatal eosinophilic myocarditis and submassive hepatic necrosis in lamotrigine induced DRESS syndrome
Criteria | Bocquet All criteria | Japanese Consensus Group All criteria | RegiSCAR Score < 2: negative; 2–3: possible; 4–5: probable; > 5: definitive |
|---|---|---|---|
Cutaneous rash | Maculopapular | Rash > 3 wks. after exposure | Rash > 50% body surface (+ 1) |
Eosinophilia or reactive lymphocytosis | Abs. Eos. > 1.5 K/µL | Abs. Eos. >1.5 K/µL; Atypical Lymphs. >5% | Abs. Eos 0.7 − 1.4 K/µL (+ 1) Abs. Eos. ≥1.5 K/µL (+ 2) Atypical Lymphs. (+ 1) |
Organ involvement: Lymphadenopathy, hepatitis, nephritis, pneumonitis, carditis | Any | Any | (+ 1 for every organ) |
Fever |  | ≥ 38.5 ° C | Yes (0), No (-1) |
Human herpesvirus type 6 (HHV-6) reactivation | Â | Yes (typical) No (atypical) | Â |
Negative work-up for autoimmune and infectious diseases |  |  | Yes (+ 1), No (0) |
Biopsy compatible with DRESS | Â | Â | Yes (0), No (-1) |
Resolution in ≥ 15 days |  |  | Yes (0), No (-1) |