Table 3 Additional cases of lamotrigine induced severe DRESS syndrome
From: Fatal eosinophilic myocarditis and submassive hepatic necrosis in lamotrigine induced DRESS syndrome
Ref.# | Age(yr.)/ Gender | Latency wks. | Presentation | Eosinophilia | Organ Involvement | Treatment | Outcome |
|---|---|---|---|---|---|---|---|
11 | 39 / M | 4 | Fever, rash, facial edema | No | Liver, kidney, hematologic | Methylprednisolone, I.V. immunoglobulin | Recovered |
12 | 21 / F | 5 | Fever, rash, lymphadenopathy | Yes | Liver, pancreas, lungs, hematologic | Methylprednisolone N-acetylcysteine | Liver transplant |
13 | 12 / M | 3 | Fever, rash, facial edema, abdominal pain | Yes | Liver | Corticosteroids, antihistamines | Recovered |
14 | 45 / F | 12 | Rash, chest pain, shortness of breath | No | Heart | Steroid, mycophenolate, mepolizumab, cyclosporine | Recovered |