Fig. 2

Annualized HAE attack frequencies by individual patients, pre- and post-index (n = 35), based on patient interviews. Index = initiation of long-term prophylaxis with C1INH(SC). Data for 35 patients are represented; some lines represent overlapping data points for individual patients. ^† This patient reported ~ 42 severe attacks per year pre-index. Frequency and severity were not notably different post-index, but the patient reported that the attacks resolved more quickly while using C1INH(SC) prophylaxis. It should also be noted that this patient’s medical chart noted a post-index attack frequency of one attack per month. *P < 0.001, pre-index versus post-index. C1INH(SC) subcutaneous C1-inhibitor, HAE hereditary angioedema, SD standard deviation