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Table 1 Baseline demographics and clinical characteristics

From: Real-world outcomes of mepolizumab for the treatment of severe eosinophilic asthma in Canada: an observational study

 

Overall PSP cohort

(N = 275)

Provincial drug coverage subset

(n = 113)

Age, years

  

   Mean (SD)

57.6 (13.5)

64.6 (12.6)

   Median (IQR)

59.0 (50.0–68.0)

68.0 (59.0–72.0)

Female, n (%)

154 (56.0%)

65 (57.5%)

Index year, n (%)

  

   2016

70 (25.5%)

25 (22.1%)

   2017

129 (46.9%)

56 (49.6%)

   2018

64 (23.3%)

27–31*

   2019

12 (4.4%)

1–5*

Rural residence, n (%)

  

   Urban

256 (93.1%)

104 (92.0%)

   Rural

19 (6.9%)

9 (8.0%)

Income quintile, n (%)

  

   Q1, lowest

50 (18.2%)

29 (25.7%)

   Q2

51 (18.6%)

16 (14.2%)

   Q3

52 (18.9%)

18 (15.9%)

   Q4

64 (23.3%)

24 (21.2%)

   Q5, highest

58 (21.1%)

26 (23.0%)

Highest eosinophil count values

n = 259 (94.2%)

n = 108–112*

   Mean (SD)

925.3 (1275.7)

894.7 (1295.6)

   Median (IQR)

620.0 (400.0–1010.0)

600.0 (325.0–950.0)

Median eosinophil count values

n = 259 (94.2%)

n = 108–112*

   Mean (SD)

540.4 (491.9)

457.8 (464.1)

   Median (IQR)

400.0 (200.0–700.0)

400.00 (200.0–600.0)

Charlson Comorbidity Index, n (%)

95 (34.5%)

45 (39.8%)

   Low 0–1

64 (23.3%)

24 (21.2%)

   Moderate 2–3

23 (8.4%)

14–18*

   High 4+

8 (2.9%)

3–7*

   Missing

180 (65.5%)

68 (60.2%)

  1. *Value reported as a range according to ICES reporting standards to reduce the risk of patient re-identification
  2. This represents the patient’s highest eosinophil count in the 12-month pre-mepolizumab period
  3. This represents the patient’s median eosinophil count in the 12-month pre-mepolizumab period
  4. ICES, Institute for Clinical and Evaluative Sciences; IQR, interquartile range; PSP, patient support program; Q, quintile; SD, standard deviation